期刊
FEBS LETTERS
卷 582, 期 20, 页码 3033-3036出版社
WILEY
DOI: 10.1016/j.febslet.2008.07.042
关键词
nitric oxide; tyrosine; nitration; ion channel; src kinase; smooth muscle
资金
- NIH [DK46367]
Tyrosine nitration results in altered function of selective proteins, including human smooth muscle L-type calcium channel, hCa(v)1.2b. We report here that Ca(v)1.2 is also subject to denitration''. Cell lysates from activated macrophage-like cell line, RAW264.7 cells, reversed peroxynitrite-induced nitration of the carboxy terminus of Cav1.2 in a 1D gel assay. Tyrosine phosphorylation of the calcium channel by c-src kinase was blocked by nitration but reversed by pretreatment with RAW264.7 cell lysates. These findings indicate that denitration may be a physiological mechanism to restore cellular excitability during inflammation. (C) 2008 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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