期刊
FEBS LETTERS
卷 583, 期 1, 页码 70-74出版社
WILEY
DOI: 10.1016/j.febslet.2008.11.025
关键词
eIF3b; HCV IRES RNA; NMR spectroscopy; RNA-protein interaction; Translation initiation
资金
- ANRS [06378CSS4-2006/2]
- Career Development Award from HFSP [CDA0029/2004-C]
Many viral mRNAs contain a 5'-UTR RNA element called internal ribosome-entry site (IRES), which bypasses the requirement of some canonical initiation factors allowing cap-independent translation. The IRES of hepatitis-C virus drives translation by directly recruiting 40S ribosomal subunits and binds to eIF3 which plays a critical role in both cap-dependent and cap-independent translation. However, the molecular basis for eIF3 activity in either case remains enigmatic. Here we report that subunit b of the eIF3 complex directly binds to HCV IRES domain III via its N-terminal-RRM. Because eIF3b was previously shown to be involved in eIF3j binding, biological implications are discussed. (c) 2008 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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