期刊
FEBS LETTERS
卷 582, 期 28, 页码 3855-3860出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2008.10.020
关键词
Beta cell; Insulin; Glucose deprivation; Apoptosis
Insulin resistant states are associated with an increase in the beta cell mass and also high levels of circulating insulin. Ultimately the beta cells undergo a failure that leads to diabetes. At this stage, a question arises if those persistent high levels of circulating insulin may contribute to beta cell damage. To address this important issue, we submitted beta cells to a prolonged effect of increasing concentrations of insulin. We observed that a prolonged effect of high levels of insulin on the presence of serum (15-24 h) in glucose-deprived beta cells induced apoptosis. This apoptotic effect was both dose- and cycloheximide-dependent. (C) 2008 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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