Article
Pharmacology & Pharmacy
Soshi Narasaki, Soma Noguchi, Tomoaki Urabe, Kana Harada, Izumi Hide, Shigeru Tanaka, Yuhki Yanase, Taketoshi Kajimoto, Kazue Uchida, Yasuo M. Tsutsumi, Norio Sakai
Summary: The aim of this study was to identify the PKC domains involved in propofol-induced PKC translocation. The results showed that the C1 and C2 domains of PKCα and the C1B domain of PKC8 are involved in propofol-induced PKC translocation. In addition, the C1 domain inhibitor calphostin C inhibited propofol-induced PKC8 translocation and phosphorylation of endothelial nitric oxide synthase.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Plant Sciences
M. Rezayian, F. Zarinkamar
Summary: This study investigated the effects of NO on plant metabolism, hormones, and secondary metabolites under salt stress in canola plants. Results showed that exogenous NO improved plant growth, increased antioxidant enzyme activity, promoted hormone balance, and enhanced salt stress tolerance.
Article
Cardiac & Cardiovascular Systems
Yiru Guo, Qianhong Li, Yu-Ting Xuan, Wen-Jian Wu, Wei Tan, Jan Slezak, Xiaoping Zhu, Alex Tomlin, Roberto Bolli
Summary: This study demonstrates that short-term, mild exercise induces delayed cardioprotective effects against myocardial infarction, dependent on the activation of eNOS, eNOS-derived NO generation, and subsequent PKC epsilon activation during preconditioning. Furthermore, the protection 24 hours after exercise is mediated by iNOS activity.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Agnieszka Zablocka, Dominika Jakubczyk, Katarzyna Leszczynska, Katarzyna Pacyga-Prus, Jozefa Macala, Sabina Gorska
Summary: This study investigated the ability of Bifidobacterium species to induce iNOS-dependent NO synthesis in macrophages. The results showed that Bifidobacterium can regulate the expression of iNOS and produce NO by activating MAPK kinases. TLR2 and TLR4 receptors are involved in Bifidobacterium-induced macrophage activation and NO production. The study suggests that Bifidobacterium has a protective mechanism in the intestine, and its efficacy is strain-dependent.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2023)
Review
Biochemistry & Molecular Biology
Amir Asgari, Paul Jurasz
Summary: Megakaryocytes are important members of the hematopoietic system, responsible for regulating vascular homeostasis through platelets. The process of megakaryopoiesis generates mature megakaryocytes which release proplatelets into blood vessels. Nitric oxide (NO) plays a modulatory role in hematopoiesis and hemostasis. This review summarizes the effect of NO and its signaling on megakaryopoiesis and thrombopoiesis under physiological and pathophysiological conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Food Science & Technology
Yang Liu, Kevin D. Croft, Jonathan M. Hodgson, Trevor Mori, Natalie C. Ward
Summary: Endothelial dysfunction may lead to atherosclerosis, while dietary nitrate/nitrite shows significant benefits on cardiovascular homeostasis. Research suggests that nitrate/nitrite may enhance eNOS activation by stimulating AMPK signaling pathway, potentially contributing to vascular protective effects.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Medicine, Research & Experimental
George J. Dugbartey
Summary: Kidney transplantation is the preferred treatment for patients with kidney failure. However, ischemia-reperfusion injury (IRI) poses a significant challenge to the long-term success of this intervention. Nitric oxide (NO) has emerged as a potential candidate for mitigating IRI and preventing graft rejection in kidney transplantation. This review provides an overview of the sources and protective effects of endogenous and exogenous NO in kidney transplantation.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Fabio Arias, Francisco Franco-Montalban, Miguel Romero, Juan Duarte, M. Dora Carrion, M. Encarnacion Camacho
Summary: This paper describes the design, synthesis, and biological evaluation of selective inhibitors of inducible nitric oxide synthase (iNOS). The most potent and selective compound showed inhibitory activity against iNOS without undesirable cardiovascular effects. In silico analysis predicted good drug-likeness properties for promising compounds, which also exhibited adequate cell viability. Docking studies revealed a unique binding mode for one compound and explained its selectivity towards iNOS.
BIOORGANIC CHEMISTRY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Lingjie Li, Lurong Jia, Siyu Hou, Tingwei Zhang, Mengjiao Zhou, Tao Chen, Jinlin Song
Summary: This study compared the time-dependent variation in inducible nitric oxide synthase (iNOS) production between the gingiva and other periodontal tissues and explored the potential association with C-reactive protein (CRP) in early periodontal disease. The results showed that iNOS and CRP levels increased rapidly in periodontal tissues, especially in the gingiva, and CRP deficiency accelerated iNOS reduction and delayed alveolar bone loss. This CRP effect on iNOS was accompanied by a change in autophagy, which was reduced by CRP knockout.
JOURNAL OF PERIODONTOLOGY
(2023)
Editorial Material
Plant Sciences
Francisco J. Corpas, Salvador Gonzalez-Gordo, Jose M. Palma
Summary: Nitric oxide is a crucial signaling molecule in plant physiological processes, but the enzymatic generation of nitric oxide in higher plants is still controversial.
TRENDS IN PLANT SCIENCE
(2022)
Article
Medicine, Research & Experimental
Jiangning Yang, Michaela L. Sundqvist, Xiaowei Zheng, Tong Jiao, Aida Collado, Yahor Tratsiakovich, Ali Mahdi, John Tengbom, Evanthia Mergia, Sergiu-Bogdan Catrina, Zhichao Zhou, Mattias Carlstroem, Takaaki Akaike, Miriam M. Cortese-Krott, Eddie Weitzberg, Jon O. Lundberg, John Pernow
Summary: Red blood cells exposed to hypoxia release cGMP, which acts as a cardioprotective mediator by activating cardiomyocyte protein kinase G. Oral administration of nitrate enhances the cardioprotective effect of hypoxic red blood cells.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Medicine, Research & Experimental
Joao Victor Silva-Silva, Carla J. Moragas-Tellis, Maria S. S. Chagas, Paulo Victor R. Souza, Davyson L. Moreira, Celeste S. F. de Souza, Kerolain F. Teixeira, Arthur R. Cenci, Aldo S. de Oliveira, Fernando Almeida-Souza, Maria D. Behrens, Katia S. Calabrese
Summary: This study evaluated the leishmanicidal activity of a crude extract and anthocyanidin-rich fractions from Arrabidaea chica, as well as three isolated anthocyanidins. The results showed promising anti-leishmanial effects of these compounds, indicating their potential as therapeutic agents for leishmaniasis.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Pharmacology & Pharmacy
Tatsiana Suvorava, Sara Metry, Stephanie Pick, Georg Kojda
Summary: Vascular tone regulation by nitric oxide is a crucial physiological function, with endothelial dysfunction potentially being an underlying cause of hypertension. Increasing eNOS activity reduces blood pressure, while decreasing activity has the opposite effect. These findings have important implications for pre-hypertensive treatment.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Plant Sciences
Pauline Chatelain, Jeremy Astier, David Wendehenne, Claire Rosnoblet, Sylvain Jeandroz
Summary: This study discusses the production and effects of NOS in plants, revealing the presence of NOS homologs in algae despite the lack of mammalian NOS homologs in land plant genomes. The identification of conserved partner proteins suggests a potential link to the regulation and functioning of NOS in mammals.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Pharmacology & Pharmacy
Akihiro Okamura, Junichiro Miake, Takuya Tomomori, Aiko Takami, Tatsuya Sawano, Masaru Kato, Kazuyoshi Ogura, Daiki Tsujimoto, Shunsuke Kawatani, Kurniawan Priyono Agung, Tomomi Notsu, Ichiro Hisatome, Kazuhiro Yamamoto, Takeshi Imamura
Summary: This study reveals that thrombin regulates vascular tone through the differential phosphorylation of eNOS via activated PAR-1, causing a temporal biphasic vascular response. Thrombin induces transient vasorelaxation by phosphorylating eNOS-Ser1177, followed by attenuation of vasorelaxation through PKC-mediated phosphorylation of eNOS-Thr495, ultimately modulating vascular tone.
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2022)