Article
Immunology
Stefan Weiss, Silva Holtfreter, Tanja C. Meyer, Frieder Schmiedeke, Clemens Cammann, Marcus Doerr, Stephan B. Felix, Hans J. Grabe, Georg Homuth, Christian Kohler, Cedric Mahncke, Stephan Michalik, Matthias Nauck, Nele Friedrich, Stefanie Samietz, Henry Voelzke, Uwe Voelker, Barbara M. Broeker
Summary: Life-threatening toxic shock syndrome is often caused by the superantigen toxic shock syndrome toxin-1 (TSST-1) produced by Staphylococcus aureus. A well-known risk factor is the lack of neutralizing antibodies. This study found that HLA class II gene loci and toxin exposure both affect the human antibody response to TSST-1.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Zhaotao Li, Pavani Beesetty, George Gerges, Maureen Kleinhenz, Melissa Moore-Clingenpeel, Ching Yang, Luul B. Ahmed, Josey Hensley, Lisa Steele, Anita S. Chong, Christopher P. Montgomery
Summary: The study found that S. aureus-specific antibody levels and T-cell responses increase with age, indicating a coordinated development of anti-staphylococcal immunity. Young infected children had higher levels of certain antibodies compared to healthy children, but these differences disappeared with age. Both global and S. aureus-specific T-cell function were impaired in children with invasive and noninvasive infections.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Immunology
Justin S. Bae, Fei Da, Ryan Liu, Lei He, Huiying Lv, Emilie L. Fisher, Govindarajan Rajagopalan, Min Li, Gordon Y. C. Cheung, Michael Otto
Summary: The study found that Staphylococcal enterotoxin B (SEB) contributes significantly to the pathogenicity of Staphylococcus aureus, suggesting the value of including SEB as a target in multipronged antistaphylococcal drug development strategies. Furthermore, it indicates that SEB contributes to fatal exacerbation of community-associated methicillin-resistant S. aureus infection.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Multidisciplinary Sciences
Stephen W. Tuffs, Mariya Goncheva, Stacey X. Xu, Heather C. Craig, Katherine J. Kasper, Joshua Choi, Ronald S. Flannagan, Steven M. Kerfoot, David E. Heinrichs, John K. McCormick
Summary: This study reveals the pathogenic mechanism of Staphylococcal superantigens (SAgs) in bacterial infections. The findings show that SAgs promote bacterial survival by manipulating the immune response to inhibit effective clearing of the bacteria. This research provides critical therapeutic targets for preventing persistent or severe Staphylococcus aureus diseases.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biology
Phuong T. M. Nguyen, Minh T. H. Nguyen, Albert Bolhuis
Summary: This study demonstrated that alpha-mangostin (AMG) loaded nanoparticles (nanoAMG) had superior antibiofilm activity compared to free AMG, effectively inhibiting biofilm formation and killing biofilm cells of Staphylococcus aureus strains, including the methicillin-resistant MRSA252. The expression of biofilm-related genes also showed noticeable differences between strains when treated with AMG or nanoAMG.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Immunology
David Aguilera-Alonso, Silke Kirchschlager Nieto, Maria Fatima Ara Montojo, Francisco Jose Sanz Santaeufemia, Jesus Saavedra-Lozano, Beatriz Soto, Maria Belen Caminoa, Arantxa Berzosa, Luis Prieto Tato, Emilia Cercenado, Alfredo Tagarro, David Molina Arana, Mercedes Alonso Sanz, Maria Pilar Romero Gomez, Fernando Chaves Sanchez, Fernando Baquero-Artigao
Summary: The incidence of Staphylococcus aureus community-acquired pneumonia (CAP) remained stable in hospitalized children with high pneumococcal vaccination coverage, while the prevalence of pneumococcal CAP decreased and Streptococcus pyogenes CAP increased. Patients with S. aureus CAP had a high frequency of severe outcomes but a lower risk of pulmonary complications compared to patients with S. pneumoniae.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2022)
Article
Microbiology
Karine Dufresne, Vladyslav A. Podskalniy, Christine A. Herfst, Gabrielle F. M. Lovell, Isaac S. Lee, Erica N. DeJong, John K. McCormick, Stephen W. Tuffs
Summary: Menstrual toxic shock syndrome (mTSS) is caused by Staphylococcus aureus strains that overproduce toxic shock syndrome toxin-1 (TSST-1). This study investigated how glucose levels in a model vaginal environment influence TSST-1 production in S. aureus. It was found that high glucose levels repress TSST-1 production, which is regulated by a protein called catabolite control protein A (CcpA). Compared to other regulatory proteins, CcpA appears to be the most important for maintaining low levels of TSST-1 in the vaginal environment, highlighting the role of environmental signaling in mTSS pathogenesis.
JOURNAL OF BACTERIOLOGY
(2022)
Article
Infectious Diseases
Li Jun Thean, Adam Jenney, Daniel Engelman, Lucia Romani, Handan Wand, Jyotishna Mani, Jessica Paka, Tuliana Cua, Sera Taole, Vika Soqo, Aalisha Sahukhan, Mike Kama, Meciusela Tuicakau, Joseph Kado, Natalie Carvalho, Margot Whitfeld, John Kaldor, Andrew C. Steer
Summary: The study shows a high incidence of invasive Staphylococcus aureus and group A Streptococcus in Fiji, especially in patients aged 65 and above. Indigenous Fijians are at a higher risk of invasive Staphylococcus aureus compared to other ethnicities. Skin and soft tissue infections are common clinical foci for both bacteria.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Genetics & Heredity
Ho Kwong Li, Xiangyun Zhi, Ana Vieira, Harry J. Whitwell, Amelia Schricker, Elita Jauneikaite, Hanqi Li, Ahmed Yosef, Ivan Andrew, Laurence Game, Claire E. Turner, Theresa Lamagni, Juliana Coelho, Shiranee Sriskandan
Summary: Streptococcus pyogenes genotype emm1 is a globally distributed epidemic clone that is highly virulent. An emm1 sublineage, M1(UK), characterized by increased levels of SpeA toxin, has caused Scarlet fever and invasive infections in England. This sublineage is dominant in England and is defined by 27 SNPs in the core genome. Comparative transcriptomic and proteomic analyses revealed minimal gene expression differences between M1(UK) and contemporary M1(global) strains. Our study suggests that the stepwise accumulation of SNPs has contributed to the emergence and dominance of M1(UK) in England.
MICROBIAL GENOMICS
(2023)
Article
Biochemistry & Molecular Biology
Viktoria Rungelrath, Frank R. DeLeo
Summary: Staphylococcus aureus is a major cause of bacterial infections worldwide, with resistance to antibiotics and the ability to evade host defenses. Research has identified certain virulence molecules of S. aureus as therapeutic targets. Treatment options for methicillin-resistant S. aureus are limited, highlighting the need for further research to develop new therapies.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Article
Microbiology
Dingle Yu, Yunmei Liang, Qinghua Lu, Qing Meng, Wenjian Wang, Lu Huang, Yanmin Bao, Ruizhen Zhao, Yunsheng Chen, Yuejie Zheng, Yonghong Yang
Summary: The disease spectrum caused by Streptococcus pyogenes is related to emm type, but not superantigens, with antibiotic resistance and resistance gene expression patterns varying in different disease categories. The distribution of vanuG and virulence genes is associated with emm type, and significant prophages and integrative conjugative elements encoding toxin and resistance genes were found in certain areas of China.
FRONTIERS IN MICROBIOLOGY
(2021)
Review
Microbiology
Vanessa Silva, Sara Araujo, Andreia Monteiro, Jose Eira, Jose Eduardo Pereira, Luis Maltez, Gilberto Igrejas, Teresa Semedo Lemsaddek, Patricia Poeta
Summary: Animal production involves the use of antimicrobial agents to promote growth and treat diseases, but it also leads to the emergence of antibiotic-resistant strains such as methicillin-resistant Staphylococcus aureus (MRSA). MRSA poses a significant threat to public health and animal welfare. Livestock-associated MRSA (LA-MRSA) was initially restricted to a specific clonal complex (CC398), but its diversity has increased over time, accompanied by multidrug resistance. This review summarizes the main clonal lineages of MRSA associated with different animals, including swine, cattle, rabbits, and poultry, and highlights the multidrug resistance patterns.
Article
Microbiology
Patrick M. Schlievert, Adriana V. Gaitan, Samuel H. Kilgore, Amy L. Roe, Johanna Maukonen, Liisa Lehtoranta, Donald Y. M. Leung, Daniel S. Marsman
Summary: This study examined the ability of two probiotic lactobacilli to inhibit the growth and toxin production of Staphylococcus aureus, as well as reduce the production of pro-inflammatory chemokines. The results showed that lactobacilli can inhibit the growth and toxin production of S. aureus, and decrease the production of chemokines induced by the toxin. These findings suggest that lactobacilli could potentially reduce the incidence of toxic shock syndrome associated with menstruation and enterocolitis.
MICROBIOLOGY SPECTRUM
(2023)
Review
Infectious Diseases
Joshua. B. Parsons, Annette. C. Westgeest, Brian. P. B. Conlon, Vance. G. Fowler
Summary: Methicillin-resistant Staphylococcus aureus (MRSA) is a deadly pathogen that can persist in the bloodstream for days despite appropriate antibiotics. Persistent MRSA bacteremia is common and associated with poor clinical outcomes. This review explores the factors related to host-pathogen interaction and discusses the clinical relevance of each element. Treatment options and diagnostic approaches for managing persistent MRSA bacteremia are also discussed.
Article
Public, Environmental & Occupational Health
Sara Quero, Marina Serras-Pujol, Noemi Parraga-Nino, Carmen Torres, Marian Navarro, Anna Vilamala, Emma Puigoriol, Javier Diez de los Rios, Elisenda Arque, Judit Serra-Pladevall, Alba Romero, Daniel Molina, Roger Paredes, Maria Luisa Pedro-Botet, Esteban Reynaga
Summary: This study investigated the prevalence of methicillin-susceptible S. aureus (MSSA) and methicillin-resistant S. aureus (MRSA) among workers in the pork production chain. The results showed that the prevalence of MRSA was high among workers in contact with live animals, especially in pig farms, livestock transporters, and slaughterhouses.
Editorial Material
Microbiology
Patrick M. Schlievert, Wilmara Salgado-Pabon, Aloysius J. Klingelhutz
FUTURE MICROBIOLOGY
(2015)
Editorial Material
Microbiology
Elizabeth A. Mueller, Joseph A. Merriman, Patrick M. Schlievert
Article
Multidisciplinary Sciences
Ashley T. Haase, Eva Rakasz, Nancy Schultz-Darken, Karla Nephew, Kimberly L. Weisgrau, Cavan S. Reilly, Qingsheng Li, Peter J. Southern, Meghan Rothenberger, Marnie L. Peterson, Patrick M. Schlievert
Article
Multidisciplinary Sciences
Kristi L. Frank, Paschalis Vergidis, Cassandra L. Brinkman, Kerryl E. Greenwood Quaintance, Aaron M. T. Barnes, Jayawant N. Mandrekar, M. Schlievert B. Patrick, Gary M. Dunny, Robin Patel
Article
Biochemistry & Molecular Biology
Alfa Herrera, Bao G. Vu, Christopher S. Stach, Joseph A. Merriman, Alexander R. Horswill, Wilmara Salgado-Pabon, Patrick M. Schlievert
Article
Multidisciplinary Sciences
Laura M. Breshears, Aaron N. Gillman, Christopher S. Stach, Patrick M. Schlievert, Marnie L. Peterson
Article
Microbiology
Heidi A. Crosby, Patrick M. Schlievert, Joseph A. Merriman, Jessica M. King, Wilmara Salgado-Pabon, Alexander R. Horswill
Article
Microbiology
Alexandra E. Paharik, Wilmara Salgado-Pabon, David K. Meyerholz, Mark J. White, Patrick M. Schlievert, Alexander R. Horswill
Article
Microbiology
Joseph A. Merriman, Elizabeth A. Mueller, Michael P. Cahill, Lisa A. Beck, Amy S. Paller, Jon M. Hanifin, Peck Y. Ong, Lynda Schneider, Denise C. Babineau, Gloria David, Alexandre Lockhart, Keli Artis, Donald Y. M. Leung, Patrick M. Schlievert
Article
Hematology
Maria Loza-Correa, Yuntong Kou, Mariam Taha, Miloslav Kalab, Jennifer Ronholm, Patrick M. Schlievert, Michael P. Cahill, Robert Skeate, Christine Cserti-Gazdewich, Sandra Ramirez-Arcos
Article
Microbiology
Alfa Herrera, Katarina Kulhankova, Vijay K. Sonkar, Sanjana Dayal, Aloysius J. Klingelhutz, Wilmara Salgado-Pabon, Patrick M. Schlievert
Article
Microbiology
Stephen W. Tuffs, David B. A. James, Jovanka Bestebroer, Amy C. Richards, Mariya I. Goncheva, Marie O'Shea, Bryan A. Wee, Keun Seok Seo, Patrick M. Schlievert, Andreas Lengeling, Jos A. van Strijp, Victor J. Torres, J. Ross Fitzgerald
Article
Food Science & Technology
Aaron N. Gillman, Laura M. Breshears, Charles K. Kistler, Patrick M. Finnegan, Victor J. Torres, Patrick M. Schlievert, Marnie L. Peterson
Article
Multidisciplinary Sciences
Christopher S. Stach, Bao G. Vu, Joseph A. Merriman, Alfa Herrera, Michael P. Cahill, Patrick M. Schlievert, Wilmara Salgado-Pabon
Article
Cell Biology
Jessica R. White, Huiyu Gong, Brock Pope, Patrick Schlievert, Steven J. McElroy
DISEASE MODELS & MECHANISMS
(2017)