Article
Plant Sciences
Guillaume Quang N'Guyen, Roxane Raulo, Antoine Porquier, Beatrice Iacomi, Sandra Pelletier, Jean-Pierre Renou, Nelly Bataille-Simoneau, Claire Campion, Bruno Hamon, Anthony Kwasiborski, Justine Colou, Abdelilah Benamar, Pietrick Hudhomme, David Macherel, Philippe Simoneau, Thomas Guillemette
Summary: This study indicates that the indolic phytoalexin primarily targets mitochondrial functions in fungal cells. Treatment of A. brassicicola with phytoalexin disrupted the mitochondrial membrane potential and led to a significant and rapid decrease in oxygen consumption rates. Secondary effects, such as Reactive oxygen species production, changes in lipid and endoplasmic reticulum homeostasis were induced. Consequently, the fungus has to adapt its metabolism to protect itself against the toxic effects of these molecules, especially via the activation of high osmolarity glycerol and cell wall integrity signaling pathways and by induction of the unfolded protein response.
FRONTIERS IN PLANT SCIENCE
(2021)
Review
Plant Sciences
Nathaniel M. Westrick, Damon L. Smith, Mehdi Kabbage
Summary: The article discusses how necrotrophic fungi overcome plant defense compounds to achieve successful pathogenesis, including strategies such as enzymatic detoxification and toxin sequestration and efflux. Efficient detoxification of host PDCs is critical for successful infection and often determines pathogen host range.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Agriculture, Multidisciplinary
Victor S. Sobolev, Travis E. Walk, Renee S. Arias, Alicia N. Massa, Valerie A. Orner, Marshall C. Lamb
Summary: The study identified that certain Aspergillus spp. from section Flavi have the ability to transform peanut phytoalexins, while other fungi and bacterial species tested did not show this capability.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Plant Sciences
Nanami Sakata, Takumi Haraguchi, Shunsuke Masuo, Takako Ishiga, Yasuhiro Ishiga
Summary: The study revealed the importance of the RND transporter in Pcal bacterial virulence and resistance to plant-derived antimicrobials, affecting Brassicaceae plants and tomatoes but not oats. The research also highlighted the involvement of the type-three secretion system (TTSS) in suppressing brassinin biosynthesis.
Review
Biotechnology & Applied Microbiology
Lijie Wang, Yan Sun
Summary: The enzymatic degradation of organophosphorus compounds is an efficient and clean approach for detoxification and bioremediation, but further improvement in catalytic efficiency and resistance is needed. Research has focused on enhancing enzyme performance through molecular mutations and engineering methods, as well as expanding substrate spectrum and designing artificial enzymes for extended applications.
BIOCHEMICAL ENGINEERING JOURNAL
(2021)
Article
Cell Biology
Taeyeon Hong, Jiyeon Ham, Jisoo Song, Gwonhwa Song, Whasun Lim
Summary: Brassinin exerts antiproliferative effects on HCC cells by reducing PCNA activity and inducing cell cycle arrest, increasing mitochondrial Ca2+ levels, generating ROS, and regulating AKT and MAPK signaling pathways. Co-administration with pharmacological inhibitors enhances its antiproliferative effects.
Article
Food Science & Technology
Min-Kyeong Lee, Heeyeon Ryu, Hyeon Hak Jeong, Bonggi Lee
Summary: Brassinin, a phytoalexin found in cabbage, has been shown to have anti-cancer and anti-inflammatory effects. This study demonstrated that brassinin can inhibit melanogenesis by reducing both the activity and mRNA expression levels of tyrosinase. These findings suggest that brassinin could be used in pharmaceutical or cosmetic products for depigmentation purposes.
Article
Chemistry, Multidisciplinary
Woon Yi Park, Ji Eon Park, Ji Hoon Jung
Summary: Brassinin, derived from Chinese cabbage, has been reported to have anti-cancer effects on prostate, liver, and colon cancer cells. This study shows that Brassinin induces apoptosis and inhibits colon cancer cells survival by activating p53, especially in wild-type p53 cancer cells, through the L5 pathway. Brassinin also enhances the apoptotic effect of doxorubicin by activating p53.
APPLIED SCIENCES-BASEL
(2021)
Review
Biochemistry & Molecular Biology
Vincent Ninkuu, Lin Zhang, Jianpei Yan, Zhenchao Fu, Tengfeng Yang, Hongmei Zeng
Summary: Biodiversity is negatively impacted by synthetic chemicals from agricultural activities, driving the shift towards sustainable agriculture. Plant secondary metabolites, particularly terpenes, offer potential as antimicrobial, insecticidal, and weed control agents, while also attracting natural enemies and beneficial insects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Plant Sciences
Wenjin Zhang, Sheng Wang, Jian Yang, Chuanzhi Kang, Luqi Huang, Lanping Guo
Summary: Plants respond to stress by forming a coordinated defense process through glycosylation modification reactions, which involve a variety of unknown glycosyltransferases and related small molecule compounds. Autotoxicity defense compounds are stored in inactive forms to release toxic aglycones and generate cascade effects.
ENVIRONMENTAL AND EXPERIMENTAL BOTANY
(2022)
Article
Chemistry, Medicinal
Min Hee Yang, Seung Ho Baek, In Jin Ha, Jae-Young Um, Kwang Seok Ahn
Summary: BSN, extracted from Chinese cabbage, has shown promising anti-neoplastic effects on colon cancer cells by modulating oncogenic signaling pathways and inducing apoptosis. Furthermore, the combination of BSN and paclitaxel synergistically increased cytotoxicity and apoptosis, suggesting BSN as a novel candidate for targeted therapy in colon cancer.
PHYTOTHERAPY RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Peramaiyan Rajendran, Hany Elsawy, Manal Alfwuaires, Azza Sedky
Summary: This study found that brassinin (BSN) could suppress hepatocarcinoma (HCC) cell growth and induce apoptosis by downregulating the JAK/STAT3 pathway. BSN generated reactive oxygen species (ROS), which increased apoptosis by activating caspase proteins. Furthermore, BSN inhibited the phosphorylation of STAT3 and JAK2, suppressing the JAK/STAT signaling cascade.
APPLIED SCIENCES-BASEL
(2022)
Article
Food Science & Technology
Noelia D. Machado, Gemma Gutierrez, Maria Matos, Mariana A. Fernandez
Summary: Resveratrol, a natural polyphenol, is encapsulated in nanovesicles formed by Tween 80 and Span 80, with or without dodecanol as membrane stabilizer. The encapsulated Resveratrol shows excellent retention and protection against high energy irradiation, making these systems suitable for various applications, especially for photosensitive compounds.
Article
Biochemistry & Molecular Biology
Hyeon Hee Kwon, Chi-Hoon Ahn, Hyo-Jung Lee, Deok Yong Sim, Ji Eon Park, Su-Yeon Park, Bonglee Kim, Bum-Sang Shim, Sung-Hoon Kim
Summary: This study found that Brassinin induces apoptosis in prostate cancer cells through ROS-mediated inhibition of SIRT1, c-Myc, beta-catenin, and glycolysis proteins.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Muhammad Syafiq Mohd Razib, Wahhida Latip, Jahwarhar Izuan Abdul Rashid, Victor Feizal Knight, Wan Md Zin Wan Yunus, Keat Khim Ong, Noor Azilah Mohd Kasim, Siti Aminah Mohd Noor
Summary: The study demonstrated the use of a phosphotriesterase mutant YT-PTE immobilized on reduced graphene oxide for electrochemical detection of organophosphate compounds. The immobilized enzyme retained 90% of its activity and exhibited high selectivity and good reproducibility towards paraoxon. Detection of paraoxon in real water samples showed minimal interferences.
JOURNAL OF CHEMISTRY
(2021)
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Mycology
M. Soledade C. Pedras, Myung Ryeol Park
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Biochemistry & Molecular Biology
M. Soledade C. Pedras, Mahla Alavi, Q. Huy To
Article
Biochemistry & Molecular Biology
M. Soledade, C. Pedras, Q. Huy To
Article
Chemistry, Multidisciplinary
M. S. C. Pedras, Q. H. To, G. Schatte
CHEMICAL COMMUNICATIONS
(2016)
Article
Chemistry, Multidisciplinary
M. S. C. Pedras, Q. H. To
CHEMICAL COMMUNICATIONS
(2016)
Article
Biochemistry & Molecular Biology
M. Soledade C. Pedras, Myung Ryeol Park
Article
Biochemistry & Molecular Biology
M. Soledade C. Pedras, Abbas Abdoli, Vijay K. Sarma-Mamillapalle
Article
Biochemistry & Molecular Biology
M. Soledade C. Pedras, Q. Huy To
Review
Chemistry, Multidisciplinary
M. Soledade, C. Pedras, Abbas Abdoli
Article
Biochemical Research Methods
M. Soledade C. Pedras, Q. Huy To
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
(2018)
Article
Chemistry, Organic
M. Soledade, C. Pedras, Q. Huy To
ORGANIC & BIOMOLECULAR CHEMISTRY
(2018)
Article
Biochemistry & Molecular Biology
M. Soledade C. Pedras, Abbas Abdoli
BIOORGANIC & MEDICINAL CHEMISTRY
(2018)
Article
Biochemistry & Molecular Biology
M. Soledade C. Pedras, Abbas Abdoli, Q. Huy To, Chintamani Thapa
CHEMISTRY & BIODIVERSITY
(2019)
Article
Biochemistry & Molecular Biology
M. Soledade C. Pedras, Chintamani Thapa
Article
Biochemistry & Molecular Biology
M. Soledade C. Pedras, Abbas Abdoli
BIOORGANIC & MEDICINAL CHEMISTRY
(2017)