期刊
FEBS JOURNAL
卷 277, 期 3, 页码 565-570出版社
WILEY
DOI: 10.1111/j.1742-4658.2009.07501.x
关键词
bouquet arrangement; double-strand break; homologous chromosome pairing; KASH domain protein; meiosis; recombination; SUN domain protein; synaptonemal complex; telomere; transcription
Recombination of homologous chromosomes is essential for correct reductional segregation of homologous chromosomes, which characterizes meiosis. To accomplish homologous recombination, chromosomes must find their homologous partners and pair with them within the spatial constraints of the nucleus. Although various mechanisms have developed in different organisms, two major steps are involved in the process of pairing: first, alignment of homologous chromosomes to bring them close to each other for recognition; and second, recognition of the homologous partner of each chromosome so that they can form an intimate pair. Here, we discuss the various mechanisms used for alignment and recognition of homologous chromosomes in meiosis.
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