期刊
FEBS JOURNAL
卷 275, 期 23, 页码 5748-5757出版社
WILEY
DOI: 10.1111/j.1742-4658.2008.06707.x
关键词
alpha-synuclein; Lewy bodies; LRRK2; MAPT; neurofibrillary tangles; paired helical filament; Parkinson's disease; ROCO protein; SNCA; tau
资金
- Brain Research Trust
- MRC [G0800437] Funding Source: UKRI
- Medical Research Council [G0800437] Funding Source: researchfish
- National Institute for Health Research [ACF-2007-21-014] Funding Source: researchfish
The last decade has seen clear links emerge between the genetic determinants and neuropathological hallmarks of parkinsonism and dementia, notably with the discovery of mutations in alpha-synuclein and tau. Following the description of mutations in LRRK2 linked to Parkinson's disease, characterized by variable pathology including either alpha-synuclein or tau deposition, it has been suggested that LRRK2 functions as an upstream regulator of Parkinson's disease pathogenesis. This minireview explores this model, in the context of our current understanding of the biochemistry of LRRK2, alpha-synuclein and tau.
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