Review
Immunology
Jingyan Guan, Congxiao Wu, Yunfan He, Feng Lu
Summary: The skin acts as a critical barrier tissue against external pathogens, with its uppermost epidermal layer and skin barrier immunity playing a vital role in maintaining its barrier function. The integrity and effectiveness of skin barrier immunity depend on the close interaction and communication between immune cells and the skin environment. Skin-associated adipocytes have been found to modulate skin immune responses and infection through the secretion of cytokines, adipokines, and antimicrobial peptides. This review summarizes recent research on the interactions between skin-associated adipocytes and other skin cells in maintaining the integrity and effectiveness of skin barrier immunity.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Gastroenterology & Hepatology
Luz del Carmen Martinez-Sanchez, Phuong Anh Ngo, Rashmita Pradhan, Lukas-Sebastian Becker, David Boehringer, Despina Soteriou, Marketa Kubankova, Christine Schweitzer, Tatyana Koch, Veronika Thonn, Lena Erkert, Iris Stolzer, Claudia Guenther, Christoph Becker, Benno Weigmann, Monika Klewer, Christoph Daniel, Kerstin Amann, Stefan Tenzer, Raja Atreya, Martin Bergo, Cord Brakebusch, Alastair J. M. Watson, Jochen Guck, Ben Fabry, Imke Atreya, Markus F. Neurath, Rocio Lopez-Posadas
Summary: Abnormal cell shedding is associated with intestinal barrier dysfunction and inflammatory bowel diseases. Deletion of PGGTase and RAC1 in intestinal epithelial cells leads to cell overcrowding and epithelial leakage, resulting in chronic intestinal inflammation. RAC1 plays a crucial role in regulating cytoskeletal dynamics, cell mechanics, and intestinal cell shedding.
Review
Biochemistry & Molecular Biology
Vera B. Dugina, Galina S. Shagieva, Anton S. Shakhov, Irina B. Alieva
Summary: Endothelial cells (EC) line the inner surface of vessels and regulate vascular permeability, with their actin cytoskeleton crucial for maintaining endothelial barrier function. Non-muscle cells express two actin isoforms, beta and gamma, which have different roles in cell survival, cell division, and neoplastic transformation depending on the cell type. The spatial organization of cytoplasmic actins in different cell types, particularly in endothelial cells, is closely linked to their functional activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Food Science & Technology
Brant M. Wagener, Ruihan Hu, Songwei Wu, Jean-Francois Pittet, Qiang Ding, Pulin Che
Summary: Pseudomonas aeruginosa is an opportunistic pathogen that causes serious infections and hospital-acquired pneumonia in immunocompromised patients, accounting for 20% of all cases of hospital-acquired pneumonia. Its ability to disrupt lung barrier integrity, leading to lung edema and bacteremia, is attributed to the poor clinical outcome of Pseudomonas aeruginosa-induced pneumonia. By modulating the cytoskeletal network and intercellular junctional complexes, Pseudomonas aeruginosa can affect the barrier function of airway epithelial and endothelial cells.
Article
Cell Biology
Anna Acheva, Tytti Karki, Niccole Schaible, Ramaswamy Krishnan, Sari Tojkander
Summary: Obesity is a major risk factor for the development of breast cancer in postmenopausal women, with the adipokine leptin strongly linked to tumor cell proliferation and metastasis. Leptin activates leptin receptors and mechanosensitive Ca2+ channels to regulate actomyosin dynamics, thus playing a role in the development of breast carcinomas.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Liufeng Dai, Baojie Wang, Ting Wang, Etienne H. Meyer, Valentin Kettel, Natalie Hoffmann, Heather E. McFarlane, Shalan Li, Xuna Wu, Kelsey L. Picard, Patrick Giavalisco, Staffan Persson, Yi Zhang
Summary: Energy is crucial for cellular functions, but how actin dynamics are regulated by ATP levels in plant cells is not well understood. This study reveals an important role for TORC1 in coordinating ATP homeostasis and actin dynamics in plant cells.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Biochemistry & Molecular Biology
Jing Gao, Fumihiko Nakamura
Summary: This review article introduces actin-associated proteins (AAPs) and their roles in regulating cell movement, shape change, division, organelle localization, and trafficking. The article lists all discovered AAPs and allows sorting based on various criteria. It also provides links to databases for accessing detailed information about protein structures, expression levels, mutations, and pathology. Additionally, small molecules targeting actin and AAPs with potential for treating diseases are listed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Coralie Mergault, Fanny Lisee, Victor Tiroille, Melia Magnien, Christelle Parent, Woodys Lenga Mabonda, Damien Sizaret, Madeleine Jaillet, Bruno Crestani, Sylvain Marchand-Adam, Laurent Plantier
Summary: The study found that the expression of the Arp2/3 complex was increased in profibrotic environments in vitro and in vivo. Inhibition of the Arp2/3 complex repressed ACTA2 and COL1 expression and blocked the Akt/phospho-GSK3 beta/beta-catenin/MRTF-A pathway in lung fibroblasts. CK666 demonstrated antifibrotic properties in the lung in vivo.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Gastroenterology & Hepatology
Li Zuo, Wei-Ting Kuo, Feng Cao, Sandra D. Chanez-Paredes, Daniel Zeve, Prabhath Mannam, Lea Jean-Francois, Anne Day, W. Vallen Graham, Yan Y. Sweat, Nitesh Shashikanth, David T. Breault, Jerrold R. Turner
Summary: MLCK1 interacts with FKBP8 to be recruited to cell junctions, leading to immune-mediated barrier loss. This finding provides a critical foundation for therapeutic exploitation of FKBP8-MLCK1 interactions.
Article
Gastroenterology & Hepatology
Yusei Hosokawa, Tetsuya Hosooka, Makoto Imamori, Kanji Yamaguchi, Yoshito Itoh, Wataru Ogawa
Summary: Insulin resistance in adipose tissue and the GAN diet have an additive effect on promoting inflammation and fibrosis in the liver, leading to the development of NAFLD-NASH. A new mouse model, A-PDK1KO mice fed with the GAN diet, is established for studying the pathogenesis of NAFLD-NASH in lean individuals and exploring potential therapeutic strategies.
HEPATOLOGY COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Siwen Wu, Linxi Li, Xiaolong Wu, Chris K. C. Wong, Fei Sun, C. Yan Cheng
Summary: AKAP9 is a crucial regulatory protein in rat testes, supporting spermatogenesis by regulating MT and actin polymerization. Its function in Sertoli cells is essential for maintaining cytoskeleton homeostasis and adhesion between Sertoli cells and GC in the testis.
Article
Biochemistry & Molecular Biology
Micaela Boiero Sanders, Christopher P. Toret, Audrey Guillotin, Adrien Antkowiak, Thomas Vannier, Robert C. Robinson, Alphee Michelot
Summary: The use of different actin isoforms in eukaryotic cells and the molecular mechanisms of their segregation into distinct networks are poorly understood. By using yeast as a model, researchers found that the expression of heterologous actin causes significant reorganization of the actin cytoskeleton. However, the expression of two heterologous actin variants, each specialized in assembling a different network, can rescue cytoskeletal organization and increase resistance to external perturbation.
Article
Multidisciplinary Sciences
Joseph Puccini, Jia Wei, Liang Tong, Dafna Bar-Sagi
Summary: Macropinocytosis is a nonselective endocytosis process that facilitates the uptake of extracellular fluid-phase cargoes. Tumor cells exploit this process to acquire macromolecules for cell growth and proliferation under nutrient-limiting conditions. This study reveals that the enzyme ATP citrate lyase (ACLY) is a key regulator of macropinocytosis, and it is involved in the actin cytoskeleton. The findings demonstrate a mechanism that links regional acetyl-CoA availability with dynamic protein acetylation, supporting the spatial and temporal modulation of membrane-cytoskeletal interactions required for macropinocytosis.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Biology
Daan Vorselen, Sarah R. Barger, Yifan Wang, Wei Cai, Julie A. Theriot, Nils C. Gauthier, Mira Krendel
Summary: The study reveals that during macrophage phagocytosis of antibody-opsonized targets, there is a prominent constriction driven by Arp2/3-mediated assembly of discrete actin protrusions. Contractile myosin-II activity contributes to late-stage phagocytic force generation and target ingestion. Observations of partial target eating attempts and sudden target release suggest that constriction may play a critical role in resolving complex in vivo target encounters.
Article
Nutrition & Dietetics
Noura B. Younes, Omnia Ahmed Mohamed, Nasser M. Rizk
Summary: This study demonstrates that DHA has the potential to mitigate obesity by reducing the secretion of inflammatory adipokines, oxidative stress, lipolysis, and apoptosis in adipocytes exposed to low O-2 tension-induced hypoxia.
Article
Biochemistry & Molecular Biology
Jean-Vianney Haure-Mirande, Minghui Wang, Mickael Audrain, Tomas Fanutza, Soong Ho Kim, Szilvia Heja, Ben Readhead, Joel T. Dudley, Robert D. Blitzer, Eric E. Schadt, Bin Zhang, Sam Gandy, Michelle E. Ehrlich
MOLECULAR PSYCHIATRY
(2019)
Article
Biochemistry & Molecular Biology
Mickael Audrain, Jean-Vianney Haure-Mirande, Minghui Wang, Soong Ho Kim, Tomas Fanutza, Paramita Chakrabarty, Paul Fraser, Peter H. St George-Hyslop, Todd E. Golde, Robert D. Blitzer, Eric E. Schadt, Bin Zhang, Michelle E. Ehrlich, Sam Gandy
MOLECULAR PSYCHIATRY
(2019)
Correction
Biochemistry & Molecular Biology
Jean-Vianney Haure-Mirande, Minghui Wang, Mickael Audrain, Tomas Fanutza, Soong Ho Kim, Szilvia Heja, Ben Readhead, Joel T. Dudley, Robert D. Blitzer, Eric E. Schadt, Bin Zhang, Sam Gandy, Michelle E. Ehrlich
MOLECULAR PSYCHIATRY
(2019)
Article
Neurosciences
Marion Rincel, Maiwenn Olier, Amandine Minni, Camille Monchaux de Oliveira, Yann Matime, Eric Gaultier, Isabelle Grit, Jean-Christophe Helbling, Anna Maria Costa, Amandine Lepinay, Marie-Pierre Moisan, Sophie Laye, Laurent Ferrier, Patricia Parnet, Vassilia Theodorou, Muriel Darnaudery
PSYCHOPHARMACOLOGY
(2019)
Article
Microbiology
Oceane C. B. Martin, Maiwenn Olier, Sandrine Ellero-Simatos, Nathalie Naud, Jacques Dupuy, Laurence Huc, Sylviane Tache, Vanessa Graillot, Mathilde Leveque, Valerie Bezirard, Cecile Helies-Toussaint, Florence Blas Y. Estrada, Valerie Tondereau, Yannick Lippi, Claire Naylies, Lindsey Peyriga, Cecile Canlet, Anne Marie Davila, Francois Blachier, Laurent Ferrier, Elisa Boutet-Robinet, Francoise Gueraud, Vassilia Theodorou, Fabrice H. F. Pierre
Article
Clinical Neurology
Ben Readhead, Jean-Vianney Haure-Mirande, Diego Mastroeni, Mickael Audrain, Tomas Fanutza, Soong H. Kim, Robert D. Blitzer, Sam Gandy, Joel T. Dudley, Michelle E. Ehrlich
ACTA NEUROPATHOLOGICA
(2020)
Article
Multidisciplinary Sciences
Noam D. Beckmann, Wei-Jye Lin, Minghui Wang, Ariella T. Cohain, Alexander W. Charney, Pei Wang, Weiping Ma, Ying-Chih Wang, Cheng Jiang, Mickael Audrain, Phillip H. Comella, Amanda K. Fakira, Siddharth P. Hariharan, Gillian M. Belbin, Kiran Girdhar, Allan Levey, Nicholas T. Seyfried, Eric B. Dammer, Duc Duong, James J. Lah, Jean-Vianney Haure-Mirande, Ben Shackleton, Tomas Fanutza, Robert Blitzer, Eimear Kenny, Jun Zhu, Vahram Haroutunian, Pavel Katsel, Sam Gandy, Zhidong Tu, Michelle E. Ehrlich, Bin Zhang, Stephen R. Salton, Eric E. Schadt
NATURE COMMUNICATIONS
(2020)
Article
Cell Biology
Ying-Wooi Wan, Rami Al-Ouran, Carl G. Mangleburg, Thanneer M. Perumal, Tom Lee, Katherine Allison, Vivek Swarup, Cory C. Funk, Chris Gaiteri, Mariet Allen, Minghui Wang, Sarah M. Neuner, Catherine C. Kaczorowski, Vivek M. Philip, Gareth R. Howell, Heidi Martini-Stoica, Hui Zheng, Hongkang Mei, Xiaoyan Zhong, Jungwoo Wren Kim, Valina L. Dawson, Ted M. Dawson, Ping-Chieh Pao, Li-Huei Tsai, Jean-Vianney Haure-Mirande, Michelle E. Ehrlich, Paramita Chakrabarty, Yona Levites, Xue Wang, Eric B. Dammer, Gyan Srivastava, Sumit Mukherjee, Solveig K. Sieberts, Larsson Omberg, Kristen D. Dang, James A. Eddy, Phil Snyder, Yooree Chae, Sandeep Amberkar, Wenbin Wei, Winston Hide, Christoph Preuss, Ayla Ergun, Phillip J. Ebert, David C. Airey, Sara Mostafavi, Lei Yu, Hans-Ulrich Klein, Gregory W. Carter, David A. Collier, Todd E. Golde, Allan Levey, David A. Bennett, Karol Estrada, T. Matthew Townsend, Bin Zhang, Eric Schadt, Philip L. De Jager, Nathan D. Price, Nilufer Ertekin-Taner, Zhandong Liu, Joshua M. Shulman, Lara M. Mangravite, Benjamin A. Logsdon
Article
Clinical Neurology
Mickael Audrain, Jean-Vianney Haure-Mirande, Justyna Mleczko, Minghui Wang, Jennifer K. Griffin, Peter H. St George-Hyslop, Paul Fraser, Bin Zhang, Sam Gandy, Michelle E. Ehrlich
Summary: The research shows that TYROBP-APOE signaling does not require TREM2 and may be an initiating step in establishing the disease-associated microglia (DAM) phenotype.
ALZHEIMERS & DEMENTIA
(2021)
Article
Biochemistry & Molecular Biology
Laurent Ferrier, Helene Eutamene, Lea Siegwald, Andrea M. Marquard, Valerie Tondereau, Julien Chevalier, Guillaume E. Jacot, Laurent Favre, Vassilia Theodorou, Maria Vicario, Andreas Rytz, Gabriela Bergonzelli, Clara L. Garcia-Rodenas
Summary: The study found that human milk oligosaccharides (HMOs) can impact visceral hypersensitivity (VHS) and alleviate abdominal pain. HMOs have the ability to modulate the microbiota, gut, and brain, playing a role in regulating pain-related functional gastrointestinal disorders.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Geriatrics & Gerontology
Shouneng Peng, Lu Zeng, Jean-Vianney Haure-Mirande, Minghui Wang, Derek M. Huffman, Vahram Haroutunian, Michelle E. Ehrlich, Bin Zhang, Zhidong Tu
Summary: The study identified shared gene expression changes between aging and LOAD, mainly in the hippocampus and several cortical regions. There is a strong interconnection between aging and LOAD in some brain regions of cognitively normal aging individuals, suggesting the potential early molecular events leading to LOAD development.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Review
Neurosciences
Jean-Vianney Haure-Mirande, Mickael Audrain, Michelle E. Ehrlich, Sam Gandy
Summary: TYROBP plays a critical role in the function of microglia and signaling of receptors related to diseases like Alzheimer's. TYROBP deficiency prevents the accumulation of C1q and may affect the neuropathological features associated with clinical cognitive function.
MOLECULAR NEURODEGENERATION
(2022)
Article
Clinical Neurology
Emilie L. Castranio, Philip Hasel, Jean-Vianney Haure-Mirande, Angie V. Ramirez Jimenez, B. Wade Hamilton, Rachel D. Kim, Charles G. Glabe, Minghui Wang, Bin Zhang, Sam Gandy, Shane A. Liddelow, Michelle E. Ehrlich
Summary: The study demonstrates that conditional Inpp5d downregulation in PSAPP mice increases plaque burden and recruitment of microglia to plaques. Spatial transcriptomics identifies an expanded plaque-specific gene expression profile.
ALZHEIMERS & DEMENTIA
(2022)
Article
Neurosciences
Georgina Perez-Garcia, Mesude Bicak, Jean-Vianney Haure-Mirande, Gissel M. Perez, Alena Otero-Pagan, Miguel A. Gama Sosa, Rita De Gasperi, Mary Sano, Carrolee Barlow, Fred H. Gage, Benjamin Readhead, Michelle E. Ehrlich, Sam Gandy, Gregory A. Eider
Summary: Tauopathies are a group of neurodegenerative disorders characterized by the accumulation of tau protein in neurons and/or glia. BCI-838 is a drug that targets metabotropic glutamate receptors and has been shown to improve learning behavior and reduce anxiety in a mouse model of Alzheimer's disease. In this study, BCI-838 was found to rescue deficits in recognition memory in mice with a tauopathy mutation. These findings suggest that BCI-838 may have potential as a treatment for tauopathy-related neurodegenerative conditions.
NEUROSCIENCE LETTERS
(2023)
Letter
Gastroenterology & Hepatology
O. Inczefi, V. Bacquie, M. Olier-Pierre, M. Rincel, B. Ringot-Destrez, S. Ellero-Simatos, H. Eutamene, C. Betoulieres, J. Thomas, J. Laine, L. Gros, M. Leveque, R. Leonard, C. Harkat, C. Robbe-Masselot, R. Roka, M. Mercier-Bonin, V. Theodorou, M. Darnaudery, J. R. Turner, L. Ferrier
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2020)