Article
Biology
Daniel Miner, Florentin Woergoetter, Christian Tetzlaff, Michael Fauth
Summary: Information processing in the brain occurs in a layered hierarchical network architecture with abundant connections within each layer and sparse long-range connections between layers. After self-organization, stimuli conveyed by sparse inputs can be rapidly read out with only a few long-range connections.
Article
Cell & Tissue Engineering
Alessandro Blasimme, Jeremy Sugarman
Summary: Human pluripotent stem cells have the potential to create in vitro models that mimic post-implantation human embryos. However, ethical concerns arise from such integrated embryo models, and it is necessary to address them in order to establish appropriate policies and regulations that support scientific innovation and medical progress.
Review
Biochemical Research Methods
Chiara Lago, Matteo Gianesello, Lucia Santomaso, Gloria Leva, Claudio Ballabio, Marica Anderle, Francesco Antonica, Luca Tiberi
Summary: This article describes a protocol for generating medulloblastoma and high-grade glioma organoids by electroporating cerebellum and forebrain organoids, and provides detailed procedures for drug screening, lineage tracing, co-culture, and in vivo assays. Human organoids derived from genetically modified cerebral organoids differentiated from hiPSCs have been shown to be a valid alternative model for studying brain cancer biology, genetics, and testing therapies. The protocol includes the generation of cerebellum and forebrain organoids, genetic modification, orthotopic transplantation, co-culture experiments, lineage tracing, and drug screening. The entire process takes 60-65 days for cancer organoid generation and 1-4 weeks for downstream applications. It requires at least 3-6 months of proficiency in hiPSCs culture, organoid generation, and procedures on immunodeficient mice.
Article
Multidisciplinary Sciences
Angus McMullen, Sascha Hilgenfeldt, Jasna Brujic
Summary: This research demonstrates that by controlling the number of bonds between particles and selecting the appropriate molecular properties of linkers, programmed microscale self-organization can be achieved to form specific structures.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Genetics & Heredity
Ildefonso M. de la Fuente, Luis Martinez, Jose Carrasco-Pujante, Maria Fedetz, Jose I. Lopez, Iker Malaina
Summary: The main sources of biomolecular order and complexity in cellular life include dissipative self-organization and molecular information processing, leading to the emergence of systemic functional structures in the cell. Through studies on enzymatic activity, functional coordination, metabolic networks, and molecular rhythms, it has been demonstrated that self-organization is central to understanding cellular processes. The quantification of biomolecular information flows in dissipative metabolic networks has enabled efficient self-regulatory control of metabolism, and the emergence of Hopfield-like dynamics characterized by associative memory has been observed in experiments with individual amoeba cells, indicating a fundamental evolutionary mechanism for cell adaptation.
FRONTIERS IN GENETICS
(2021)
Article
Computer Science, Artificial Intelligence
Carlos Gershenson
Summary: Despite the long history of using concepts similar to emergence, there is still no agreed definition. However, emergence is recognized as a key feature of complex systems. Understanding emergence and complexity can greatly contribute to the study of living systems.
Article
Cell & Tissue Engineering
Ayaka Yanagida, Daniel Spindlow, Jennifer Nichols, Anish Dattani, Austin Smith, Ge Guo
Summary: Researchers have developed a human embryo model called blastoid through self-organization, which can form blastocyst-like structures within a short period of time, displaying three tissue layers and mimicking natural blastocysts. Single-cell transcriptome analysis confirms the high fidelity of the blastoid model, providing a versatile and scalable experimental model for human embryo research.
Article
Cell Biology
Xulun Wu, Wentao Zhao, Hao Wu, Qiancheng Zhang, Yiming Wang, Kunyuan Yu, Jinglei Zhai, Fan Mo, Meijiao Wang, Shiwen Li, Xili Zhu, Xiaoyan Liang, Baoyang Hu, Guang-Hui Liu, Jun Wu, Hongmei Wang, Fan Guo, Leqian Yu
Summary: The interactions between extra-embryonic tissues and embryonic tissues are crucial for proper early embryo development. However, the understanding of this crosstalk is limited due to ethical restrictions, difficulty in obtaining natural human embryos, and lack of appropriate in vitro models. Our study showed that by aggregating human embryonic stem cells with human trophoblast stem cells, hESCs self-organized into an asymmetric structure with primitive streak-like cells exclusively located at one end and morphologically flattened cells presumed to be extra-embryonic mesoderm cells induced at the opposite end. This research revealed potential roles of the extra-embryonic trophectoderm in regulating proper primitive streak formation and inducing extra-embryonic mesoderm cells from the human epiblast.
CELL PROLIFERATION
(2023)
Article
Multidisciplinary Sciences
Tatsuya Fukuyama, Lucan Yan, Masahito Tanaka, Megumi Yamaoka, Kei Saito, Shih-Chieh Ti, Chung-Chi Liao, Kuo-Chiang Hsia, Yusuke T. Maeda, Yuta Shimamoto
Summary: The spindle is a dynamic intracellular structure essential for chromosome segregation during cell division. It can exhibit varied shape morphologies through nonrandom, bistable self-organization paths. The emergence of different spindle shapes is influenced by both physical and molecular factors.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Multidisciplinary Sciences
Saradha Venkatachalapathy, Dyuthi Sreekumar, Prasuna Ratna, G. Shivashankar
Summary: This study reveals the importance of actomyosin contractile forces in regulating heterogeneous cell-fate decisions. Mechanical checkpoints contribute to the heterogeneity in cell state transitions.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Bailey A. T. Weatherbee, Carlos W. Gantner, Lisa K. Iwamoto-Stohl, Riza M. Daza, Nobuhiko Hamazaki, Jay Shendure, Magdalena Zernicka-Goetz
Summary: By inducing stem cells, we have established a model of the human post-implantation embryo that mimics key aspects of human development and allows us to study tissue-tissue interactions. This model is important for investigating critical questions related to human post-implantation development and understanding the causes of pregnancy failure during this stage.
Article
Multidisciplinary Sciences
Felix Mueller, Luis Escobar, Felix Xu, Ewa Wegrzyn, Milda Nainyte, Tynchtyk Amatov, Chun-Yin Chan, Alexander Pichler, Thomas Carell
Summary: The RNA world hypothesis suggests that life evolved from self-replicating RNA molecules. However, the transition from the RNA world to the dominance of proteins as catalysts remains a mystery. Recent research has shown that non-canonical RNA bases, considered relics of the RNA world, can directly facilitate peptide synthesis on RNA, indicating the existence of an early RNA-peptide world.
Article
Business
Artur Swierczek
Summary: This study investigates the relationship between information governance, decentralized information technologies, supply chain self-organization, and network performance in transitive service triads. The findings suggest that information governance, supply chain self-organization, and decentralized information technologies are interconnected and play a crucial role in improving network performance. The study provides valuable insights into the dynamics of transitive service triads and contributes to the understanding of supply chain management.
SUPPLY CHAIN MANAGEMENT-AN INTERNATIONAL JOURNAL
(2023)
Article
Nutrition & Dietetics
Karla Vazquez-Espino, Gil Rodas-Font, Andreu Farran-Codina
Summary: The study aimed to assess the nutrition knowledge of athletes from Futbol Club Barcelona and its association with self-perceived level of nutrition knowledge, attitude towards nutrition, sources of information, and dietary habits. The findings revealed that athletes had low levels of nutrition knowledge compared to technical teams and nutrition students. There were significant associations between nutrition knowledge and self-perceived level of knowledge, intake of fruits and vegetables, and intake of discretionary food.
Article
Multidisciplinary Sciences
Xiaoliang Wang, Dongyun Bai
Summary: The exact self-organization mechanism underlying complex multi-physics coupling developmental processes has been studied using multiscale computations based on first principles. It was found that cell cycles can self-organize into periodic stripes in E. coli populations, relying on a moving graded nutrient concentration profile to provide positional information for cells. The research also showed that the statistical cell cycle distribution can collapse to a universal function and exhibit scale invariance, with transitions between gene patterns depending on the radial distribution mode of genetic oscillations in cell populations.
ADVANCED THEORY AND SIMULATIONS
(2021)
Article
Clinical Neurology
Vincent Wens, Mathieu Bourguignon, Serge Goldman, Brice Marty, Marc Op de Beeck, Catherine Clumeck, Alison Mary, Philippe Peigneux, Patrick Van Bogaert, Matthew J. Brookes, Xavier De Tiege
Letter
Clinical Neurology
Vincent Wens, Alison Mary, Mathieu Bourguignon, Serge Goldman, Brice Marty, Marc Op de Beeck, Patrick Van Bogaert, Philippe Peigneux, Xavier De Tiege
CLINICAL NEUROPHYSIOLOGY
(2014)
Article
Radiology, Nuclear Medicine & Medical Imaging
Benjamin Bondue, Felicie Sherer, Gaetan Van Simaeys, Gilles Doumont, Dominique Egrise, Yousof Yakoub, Francois Huaux, Marc Parmentier, Sandrine Rorive, Sebastien Sauvage, Simon Lacroix, Olivier Vosters, Paul De Vuyst, Serge Goldman
JOURNAL OF NUCLEAR MEDICINE
(2015)
Article
Multidisciplinary Sciences
Catherine Clumeck, Sarah Suarez Garcia, Mathieu Bourguignon, Vincent Wens, Marc Op de Beeck, Brice Marty, Nicolas Deconinck, Marie-Vincianne Soncarrieu, Serge Goldman, Veikko Jousmaki, Patrick Van Bogaert, Xavier De Tiege
Article
Neurosciences
Marc Vander Ghinst, Mathieu Bourguignon, Maxime Niesen, Vincent Wens, Sergio Hassid, Georges Choufani, Oveildco Jousmaki, Riitta Hari, Serge Goldman, Xavier De Tiege
JOURNAL OF NEUROSCIENCE
(2019)
Article
Neurosciences
Jeroen Van Schependom, Diego Vidaurre, Lars Costers, Martin Sjogard, Marie B. D'hooghe, Miguel D'haeseleer, Vincent Wens, Xavier De Tiege, Serge Goldman, Mark Woolrich, Guy Nagels
HUMAN BRAIN MAPPING
(2019)
Article
Neurosciences
Lars Costers, Jeroen Van Schependom, Jorne Laton, Johan Baijot, Martin Sjogard, Vincent Wens, Xavier De Tiege, Serge Goldman, Miguel D'Haeseleer, Marie Beatrice D'hooghe, Mark Woolrich, Guy Nagels
HUMAN BRAIN MAPPING
(2020)
Article
Neurosciences
Lars Costers, Jeroen Van Schependom, Jorne Laton, Johan Baijot, Martin Sjogard, Vincent Wens, Xavier De Tiege, Serge Goldman, Miguel D'Haeseleer, Marie Beatrice D'hooghe, Mark Woolrich, Guy Nagels
Summary: This study found that MS patients showed a smaller maximum theta power increase in the right hippocampus between 0 and 400 ms compared to healthy subjects, and this increase value correlated negatively with reaction time on the task in MS. The results provide evidence of the influence of hippocampal dysfunction on working memory performance in MS.
HUMAN BRAIN MAPPING
(2021)
Article
Oncology
Corentin Martens, Olivier Debeir, Christine Decaestecker, Thierry Metens, Laetitia Lebrun, Gil Leurquin-Sterk, Nicola Trotta, Serge Goldman, Gaetan Van Simaeys
Summary: Recent research on dynamic amino acid positron emission tomography (PET) in gliomas has shown potential for extracting key features with the use of principal component analysis (PCA) to better understand intra-tumor heterogeneity. The PCA model outperforms traditional pharmacokinetic modeling in distinguishing characteristic dynamic uptake behaviors within the tumor.
Article
Radiology, Nuclear Medicine & Medical Imaging
Celine Mathey, Caroline Keyzer, Didier Blocklet, Gaetan Van Simaeys, Nicola Trotta, Simon Lacroix, Bernard Corvilain, Serge Goldman, Rodrigo Moreno-Reyes
Summary: This study found that F-18-FCH PET/CT performs better than C-11-MET PET/CT in detecting and localizing abnormal parathyroid tissue in patients with pHPT when Tc-99m-MIBI SPECT results are negative or inconclusive.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Odile Feys, Pierre Corvilain, Alec Aeby, Claudine Sculier, Niall Holmes, Matthew Brookes, Serge Goldman, Vincent Wens, Xavier De Tiege, Florence Christiaens
Summary: This study compared the effectiveness of cryogenic and on-scalp MEG in detecting and localizing focal interictal epileptiform discharges (IEDs) in children with epilepsy. The results showed that on-scalp MEG had higher IED amplitudes and signal-to-noise ratios compared to cryogenic MEG, and the localization value was similar between the two modalities.
Article
Oncology
Corentin Martens, Antonin Rovai, Daniele Bonatto, Thierry Metens, Olivier Debeir, Christine Decaestecker, Serge Goldman, Gaetan Van Simaeys
Summary: This research proposed a deep learning-based approach to address problems in glioma growth models. By training deep neural networks, it is possible to reconstruct the cell-density distribution of the tumor and accurately evaluate model parameters. This approach has significant potential application value for glioma characterization and therapy planning.
Article
Radiology, Nuclear Medicine & Medical Imaging
Corentin Martens, Laetitia Lebrun, Christine Decaestecker, Thomas Vandamme, Yves-Remi Van Eycke, Antonin Rovai, Thierry Metens, Olivier Debeir, Serge Goldman, Isabelle Salmon, Gaetan Van Simaeys
Summary: This study uses a 3D-printed slicer for stereotactic histological analysis of an unoperated brain with glioblastoma, revealing limitations of conventional MRI in deriving glioma cell density maps and emphasizing the need for other initialization methods for reaction-diffusion models in clinical practice.
Letter
Clinical Neurology
Pasquale Scoppettuolo, Noemie Ligot, Myriam Remmelink, Isabelle Delpierre, Serge Goldman, Gilles Naeije, Frederic Vandergheynst
JOURNAL OF CLINICAL NEUROLOGY
(2021)
Article
Clinical Neurology
N. Verburg, F. W. A. Hoefnagels, F. Barkhof, R. Boellaard, S. Goldman, J. Guo, J. J. Heimans, O. S. Hoekstra, R. Jain, M. Kinoshita, P. J. W. Pouwels, S. J. Price, J. C. Reijneveld, A. Stadlbauer, W. P. Vandertop, P. Wesseling, A. H. Zwinderman, P. C. De Witt Hamer
AMERICAN JOURNAL OF NEURORADIOLOGY
(2017)
