Article
Biochemical Research Methods
Adrian L. Hauber, Marcus Rosenblatt, Jens Timmer
Summary: Ordinary differential equations are commonly used for mathematical modeling in biological systems. Identifying cell-type specific mechanisms is crucial in building useful models and understanding biological processes. Existing regularization techniques are inconsistent when analyzing more than two cell types. To address this, the paper proposes incorporating the clustered LASSO into ordinary differential equation modeling by penalizing pairwise differences of fold-change parameters. This approach renders the results independent of the reference cell type. The paper demonstrates the performance of the method using realistic biological models and synthetic data, and also applies it to published biological models with experimental data.
PLOS COMPUTATIONAL BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Zhengri Lu, Mengen Deng, Genshan Ma, Lijuan Chen
Summary: This study aimed to investigate the role and mechanisms of TRIM38 in myocardial ischemia/reperfusion (I/R) injury. The results showed that TRIM38 expression can alleviate inflammatory responses and oxidative stress, inhibit apoptosis, and attenuate cellular injury by suppressing the TAK1/NF-kappa B pathway activity.
Article
Environmental Sciences
Ge Guan, Huilan Su, Xiaoran Wei, Yuxin Zheng, Xiaoting Jin
Summary: The study found that TBBPA significantly induced proliferation of Ishikawa cells by activating NF-κB and mediating the upregulation of inflammatory cytokines through IκB' degradation. In vivo experiments confirmed the mechanism, suggesting that ubiquitin-mediated IκB' degradation and inflammatory response may serve as critical biomarkers for TBBPA-induced endometrial carcinoma.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Biochemistry & Molecular Biology
Khalid Saad Alharbi, Obaid Afzal, Waleed Hassan Almalki, Imran Kazmi, Mohammad Arshad Javed Shaikh, Lakshmi Thangavelu, Monica Gulati, Sachin Kumar Singh, Niraj Kumar Jha, Piyush Kumar Gupta, Dinesh Kumar Chellappan, Brian George Oliver, Kamal Dua, Gaurav Gupta
Summary: Nutraceuticals, as dietary supplements, have the potential to improve health, prevent diseases, and maintain normal body function. This review discusses the medical value of nutraceuticals in targeting the NF-kappa B pathway to mitigate inflammatory lung diseases.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Food Science & Technology
Abeer A. Al-Masri, Fuad Ameen
Summary: Banana is an important fruit crop worldwide. In this study, an anthocyanin-rich extract from banana bract (BBA) was prepared and characterized. BBA showed antioxidant and anti-inflammatory activity in LPS-stimulated macrophage-like cells. The presence of phenolic compounds, flavonoids, and anthocyanin in BBA was identified. BBA increased endogenous antioxidants and inhibited the nuclear translocation of NF-kappaB under LPS-stimulated conditions, indicating its potential as an anti-inflammatory agent.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Environmental Sciences
Dan Wang, Zhenzhen Tan, Jing Yang, Longfei Li, Haoran Li, Huaxing Zhang, Heqiong Liu, Yi Liu, Lei Wang, Qian Li, Huicai Guo
Summary: This study aimed to investigate the effects of PFOS exposure on atherosclerosis progression and the underlying mechanisms. The results showed that PFOS increased pulse wave velocity, intima-media thickness, aortic plaque burden, and levels of serum lipids and inflammatory cytokines. PFOS promoted M1 macrophage polarization and suppressed M2 macrophage polarization, leading to inflammation. NF-κB activation in macrophages was associated with this process. These findings highlight the role of PFOS in accelerating atherosclerosis progression through NF-κB-mediated inflammation.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Review
Immunology
Marion Mussbacher, Martina Derler, Jose Basilio, Johannes A. Schmid
Summary: Nuclear factor kappa B (NF-kappa B) is a dimeric transcription factor that regulates the expression of chemokines, cytokines, transcription factors, and regulatory proteins, playing a crucial role in inflammation and immunity. Understanding its specific roles in different cell types, tissues, and under different stimuli is important. This review focuses on the role of NF-kappa B in monocytes and macrophages, innate immune cells that exhibit high plasticity and adjust their functions against pathogens and cues from the environment. NF-kappa B activation in macrophages has significant implications in inflammatory diseases and its temporal dynamics are complex.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, Research & Experimental
Kehinde S. Olaniyi, Stephanie E. Areloegbe
Summary: This study investigated the effects of acetate on cardiometabolic abnormalities associated with polycystic ovarian syndrome (PCOS) in a rat model. The results suggest that acetate protects against cardiac inflammation by suppressing PCSK9 and NF-kB-dependent mechanisms.
Article
Dentistry, Oral Surgery & Medicine
Shaohua Cong, Qian Peng, Liou Cao, Qingqing Yi, Yi Liu, Linhui Li, Qingchun Tong, Dongyu Liang
Summary: This study investigated the effects of diosgenin on periodontitis and found that it inhibited inflammatory responses and the activation of NF-kappa B pathway while promoting osteogenesis. Administering diosgenin to periodontitis rats also reduced the levels of inflammatory factors and NF-kappa B in gingival tissue, and promoted the expression of osteoblast-related genes. These findings suggest that diosgenin may be a potential therapeutic strategy for treating periodontitis in the future.
Article
Immunology
Baohua Liu, Xiaomin Miao, Jiangyun Shen, Liyan Lou, Kangmin Chen, Fuqi Mei, Meng Chen, Xian Su, Xue Du, Zhenhu Zhu, Weihong Song, Xu Wang
Summary: Diabetic kidney disease (DKD) is a common complication of diabetes, and the understanding of its molecular mechanisms is still incomplete. A recent study found that the expression of deubiquitinating enzyme USP25 was significantly upregulated in the kidneys of diabetic mice, and its absence worsened diabetes-induced renal dysfunction and fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Cell Biology
Jack Li, Sijin Liu, Shitao Li
Summary: Linear ubiquitination is an important protein modification that attaches a head-to-tail polyubiquitin chain to a substrate protein to mediate signaling pathways. It plays a critical role in various types of cancers, and dysregulation of linear ubiquitination may contribute to tumorigenesis and cancer development.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Oncology
Fengen Liu, Binhui Xie, Rong Ye, Yuankang Xie, Baiyin Zhong, Jinrong Zhu, Yao Tang, Zelong Lin, Huiru Tang, Ziqing Wu, Heping Li
Summary: In this study, it was found that overexpression of TRIM47 is associated with tumor progression and poor prognosis in triple-negative breast cancer. The researchers demonstrated that TRIM47 directly interacts with BRCA1 and induces proteasome turnover of BRCA1, leading to a decrease in BRCA1 protein levels in TNBC. Additionally, TRIM47 overexpression confers sensitivity to the PARP inhibitor olaparib, while TRIM47 inhibition confers resistance to olaparib in TNBC. Overexpression of BRCA1 also increases resistance to olaparib in TRIM47-overexpression-induced PARP inhibition sensitivity. These findings suggest that targeting the TRIM47/BRCA1 axis may be a promising prognostic factor and therapeutic target for TNBC.
Article
Urology & Nephrology
Guibao Ke, Xueqin Chen, Ruyi Liao, Lixia Xu, Li Zhang, Hong Zhang, Sujuan Kuang, Yue Du, Juan Hu, Zhiwen Lian, Caoshuai Dou, Qianmei Zhang, Xingchen Zhao, Fengxia Zhang, Shuangshuang Zhu, Jianchao Ma, Zhuo Li, Sijia Li, Chaosheng He, Xia Chen, Yingzhen Wen, Zhonglin Feng, Minghao Zheng, Ting Lin, Ruizhao Li, Bohou Li, Wei Dong, Yuanhan Chen, Wenjian Wang, Zhiming Ye, Chunyu Deng, Houqin Xiao, Jie Xiao, Xinling Liang, Wei Shi, Shuangxin Liu
Summary: The expression of Receptor activator of NF-kappa B (RANK) is increased in podocytes of patients with diabetic nephropathy. Mouse models of podocyte-specific RANK depletion and overexpression showed that RANK depletion alleviated the development of kidney diseases, while RANK overexpression aggravated the condition. The findings suggest that RANK mediates the development of diabetic nephropathy by promoting glomerular oxidative stress and proinflammatory cytokine production.
KIDNEY INTERNATIONAL
(2021)
Article
Plant Sciences
Yating Wang, Xiurong Bao, Hao Xian, Fang Wei, Yining Song, Siyu Zhao, Yujie Zhang, Yumeng Wang, Ying Wang
Summary: This study investigates the role and potential mechanisms of ginsenoside metabolite compound K (CK) in the treatment of rheumatoid arthritis (RA). The results demonstrate that CK can reduce arthritis symptoms and inhibit inflammation-related genes and pathways. These findings contribute to the understanding of the molecular mechanism of CK in treating RA.
PHARMACEUTICAL BIOLOGY
(2023)
Review
Immunology
Yan Liu, Kai Xu, Yin Yao, Zheng Liu
Summary: This article reviews the role of A20 in allergic airway diseases, finding that A20 can regulate the inflammatory response in these diseases by inhibiting the NF-κB signaling pathway, thus exerting anti-inflammatory effects. The gene polymorphisms of A20 are also associated with allergic airway diseases.
FRONTIERS IN IMMUNOLOGY
(2023)
