Adaptive dysfunction of selenoproteins from the perspective of the triage theory: why modest selenium deficiency may increase risk of diseases of aging

Both Maximal Expression of Selenoproteins and Selenoprotein Deficiency Can Promote Development of Type 2 Diabetes-Like Phenotype in Mice

(2011) Vyacheslav M. Labunskyy et al.   ANTIOXIDANTS & REDOX SIGNALING

Editorial

(2011) Etsuo Niki et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

Selenoprotein K Knockout Mice Exhibit Deficient Calcium Flux in Immune Cells and Impaired Immune Responses

(2011) S. Verma et al.   JOURNAL OF IMMUNOLOGY

Optimization of selenoprotein P and other plasma selenium biomarkers for the assessment of the selenium nutritional requirement: a placebo-controlled, double-blind study of selenomethionine supplementation in selenium-deficient Chinese subjects

(2010) Yiming Xia et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Establishing optimal selenium status: results of a randomized, double-blind, placebo-controlled trial

(2010) Rachel Hurst et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Meta-analyses of genes modulating intracellular T3 bio-availability reveal a possible role for the DIO3 gene in osteoarthritis susceptibility

(2010) I. Meulenbelt et al.   ANNALS OF THE RHEUMATIC DISEASES

Thyroid and bone

(2010) Apostolos I. Gogakos et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Serum selenium and serum lipids in US adults: National Health and Nutrition Examination Survey (NHANES) 2003–2004

(2010) Martin Laclaustra et al.   ATHEROSCLEROSIS

Thioredoxin and thioredoxin reductase: Current research with special reference to human disease

(2010) Arne Holmgren et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mammalian thioredoxin reductase 1: roles in redox homoeostasis and characterization of cellular targets

(2010) Anton A. Turanov et al.   BIOCHEMICAL JOURNAL

Human Protein Atlas of redox systems — What can be learnt?

(2010) Pascal Dammeyer et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

A prospective study of dietary selenium intake and risk of type 2 diabetes

(2010) Saverio Stranges et al.   BMC PUBLIC HEALTH

The choice of biomarkers determines the selenium status in young German vegans and vegetarians

(2010) Johanna Hoeflich et al.   BRITISH JOURNAL OF NUTRITION

Selenium and Bladder Cancer Risk: a Meta-analysis

(2010) A. F. S. Amaral et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Effects of Selenium Status and Polymorphisms in Selenoprotein Genes on Prostate Cancer Risk in a Prospective Study of European Men

(2010) A. Steinbrecher et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Loss of Thioredoxin Reductase 1 Renders Tumors Highly Susceptible to Pharmacologic Glutathione Deprivation

(2010) P. K. Mandal et al.   CANCER RESEARCH

Functional and physical interaction between the selenium-binding protein 1 (SBP1) and the glutathione peroxidase 1 selenoprotein

(2010) Wenfeng Fang et al.   CARCINOGENESIS

Genetic variants in selenoprotein genes increase risk of colorectal cancer

(2010) C. Meplan et al.   CARCINOGENESIS

A Liver-Derived Secretory Protein, Selenoprotein P, Causes Insulin Resistance

(2010) Hirofumi Misu et al.   Cell Metabolism

Thyroid disease and mental disorders: cause and effect or only comorbidity?

(2010) Robertas Bunevičius et al.   CURRENT OPINION IN PSYCHIATRY

Association of the type 2 deiodinase Thr92Ala polymorphism with type 2 diabetes: case–control study and meta-analysis

(2010) José Miguel Dora et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Selenoproteins—What unique properties can arise with selenocysteine in place of cysteine?

(2010) Elias S.J. Arnér   EXPERIMENTAL CELL RESEARCH

Proinflammatory cytokines down-regulate intestinal selenoprotein P biosynthesis via NOS2 induction

(2010) Bodo Speckmann et al.   FREE RADICAL BIOLOGY AND MEDICINE

Polymorphisms in the selenoprotein S and 15-kDa selenoprotein genes are associated with altered susceptibility to colorectal cancer

(2010) Alison Sutherland et al.   Genes and Nutrition

Insights into Function, Catalytic Mechanism, and Fold Evolution of Selenoprotein Methionine Sulfoxide Reductase B1 through Structural Analysis

(2010) Finn L. Aachmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The type 2 deiodinase Thr92Ala polymorphism is associated with increased bone turnover and decreased femoral neck bone mineral density

(2010) Karen A Heemstra et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Hepatocytes lacking thioredoxin reductase 1 have normal replicative potential during development and regeneration

(2010) M. F. Rollins et al.   JOURNAL OF CELL SCIENCE

Mutations in the selenocysteine insertion sequence–binding protein 2 gene lead to a multisystem selenoprotein deficiency disorder in humans

(2010) Erik Schoenmakers et al.   JOURNAL OF CLINICAL INVESTIGATION

Understanding ageing from an evolutionary perspective

(2010) T. B. L. Kirkwood   JOURNAL OF INTERNAL MEDICINE

The Efficiency of Selenocysteine Incorporation Is Regulated by Translation Initiation Factors

(2010) Jesse Donovan et al.   JOURNAL OF MOLECULAR BIOLOGY

Dietary Selenium Modulates Activation and Differentiation of CD4+ T Cells in Mice through a Mechanism Involving Cellular Free Thiols

(2010) FuKun W. Hoffmann et al.   JOURNAL OF NUTRITION

mRNA transcripts as molecular biomarkers in medicine and nutrition☆

(2010) Roger A. Sunde   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Genetics and phenomics of selenoenzymes—How to identify an impaired biosynthesis?

(2010) Lutz Schomburg   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Nucleolin binds to a subset of selenoprotein mRNAs and regulates their expression

(2010) Angela C. Miniard et al.   NUCLEIC ACIDS RESEARCH

Plasma selenium and risk of dysglycemia in an elderly French population: results from the prospective Epidemiology of Vascular Ageing Study

(2010) Tasnime N Akbaraly et al.   Nutrition & Metabolism

Association study between polymorphisms in selenoprotein genes and susceptibility to Kashin-Beck disease

(2010) Y.M. Xiong et al.   OSTEOARTHRITIS AND CARTILAGE

Selenoproteins Are Essential for Proper Keratinocyte Function and Skin Development

(2010) Aniruddha Sengupta et al.   PLoS One

Optimal bone strength and mineralization requires the type 2 iodothyronine deiodinase in osteoblasts

(2010) J. H. D. Bassett et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of selenium-containing proteins in T-cell and macrophage function

(2010) Bradley A. Carlson et al.   PROCEEDINGS OF THE NUTRITION SOCIETY

Insulin signaling meets mitochondria in metabolism

(2010) Zhiyong Cheng et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Methods of assessment of selenium status in humans: a systematic review

(2009) Kate Ashton et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Vitamin K, an example of triage theory: is micronutrient inadequacy linked to diseases of aging?

(2009) Joyce C McCann et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Relative Abundance of Selenoprotein P Isoforms in Human Plasma Depends on Genotype, Se Intake, and Cancer Status

(2009) Catherine Méplan et al.   ANTIOXIDANTS & REDOX SIGNALING

Regulation of Selenoproteins and Methionine Sulfoxide Reductases A and B1 by Age, Calorie Restriction, and Dietary Selenium in Mice

(2009) Sergey V. Novoselov et al.   ANTIOXIDANTS & REDOX SIGNALING

The Syndrome of Inherited Partial SBP2 Deficiency in Humans

(2009) Alexandra M. Dumitrescu et al.   ANTIOXIDANTS & REDOX SIGNALING

Threading the Needle: Getting Selenocysteine Into Proteins

(2009) Jesse Donovan et al.   ANTIOXIDANTS & REDOX SIGNALING

Unveiling the Molecular Mechanisms Behind Selenium-Related Diseases Through Knockout Mouse Studies

(2009) Marcus Conrad et al.   ANTIOXIDANTS & REDOX SIGNALING

Selenoproteins and Protection against Oxidative Stress: Selenoprotein N as a Novel Player at the Crossroads of Redox Signaling and Calcium Homeostasis

(2009) Sandrine Arbogast et al.   ANTIOXIDANTS & REDOX SIGNALING

Selenium and the Selenoprotein Thioredoxin Reductase in the Prevention, Treatment and Diagnostics of Cancer

(2009) Markus Selenius et al.   ANTIOXIDANTS & REDOX SIGNALING

Selenium and Selenoproteins in Health and Disease

(2009) Laura V. Papp et al.   ANTIOXIDANTS & REDOX SIGNALING

Serum selenium and prognosis in cardiovascular disease: results from the AtheroGene study

(2009) Edith Lubos et al.   ATHEROSCLEROSIS

Selenium and thyroid

(2009) Josef Köhrle et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Regulation and function of selenoproteins in human disease

(2009) Frederick P. Bellinger et al.   BIOCHEMICAL JOURNAL

Selenoprotein function and muscle disease

(2009) Alain Lescure et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Glutathione peroxidases in different stages of carcinogenesis

(2009) Regina Brigelius-Flohé et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Selenoproteins that function in cancer prevention and promotion

(2009) Dolph L. Hatfield et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Molecular mechanisms by which selenoproteins affect cancer risk and progression

(2009) Pin Zhuo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Functions and evolution of selenoprotein methionine sulfoxide reductases

(2009) Byung Cheon Lee et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Selenoproteins and human health: Insights from epidemiological data

(2009) Margaret P. Rayman   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Hierarchical regulation of selenoprotein expression and sex-specific effects of selenium

(2009) Lutz Schomburg et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Protection against reactive oxygen species by selenoproteins

(2009) Holger Steinbrenner et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Selenoprotein P—Expression, functions, and roles in mammals

(2009) Raymond F. Burk et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Transgenic mouse models for the vital selenoenzymes cytosolic thioredoxin reductase, mitochondrial thioredoxin reductase and glutathione peroxidase 4

(2009) Marcus Conrad   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Focus on mammalian thioredoxin reductases — Important selenoproteins with versatile functions

(2009) Elias S.J. Arnér   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Selenium deficiency impairs host innate immune response and induces susceptibility to Listeria monocytogenes infection

(2009) Chengmin Wang et al.   BMC IMMUNOLOGY

Reactive Oxygen Species Enhance Insulin Sensitivity

(2009) Kim Loh et al.   Cell Metabolism

Nonsense-mediated mRNA decay in human cells: mechanistic insights, functions beyond quality control and the double-life of NMD factors

(2009) Pamela Nicholson et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The human selenoproteome: recent insights into functions and regulation

(2009) M. A. Reeves et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Life without Thyroxine to 3,5,3′-Triiodothyronine Conversion: Studies in Mice Devoid of the 5′-Deiodinases

(2009) Valerie Anne Galton et al.   ENDOCRINOLOGY

Serum Selenium Concentrations and Diabetes in U.S. Adults: National Health and Nutrition Examination Survey (NHANES) 2003–2004

(2009) Martin Laclaustra et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Glutathione peroxidase-2 protects from allergen-induced airway inflammation in mice

(2009) A. M. Dittrich et al.   EUROPEAN RESPIRATORY JOURNAL

Selenium Requirements Are Higher for Glutathione Peroxidase-1 mRNA than Gpx1 Activity in Rat Testis

(2009) Sonja C. Schriever et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Mitochondrial glutathione peroxidase 4 disruption causes male infertility

(2009) Manuela Schneider et al.   FASEB JOURNAL

Penultimate selenocysteine residue replaced by cysteine in thioredoxin reductase from selenium-deficient rat liver

(2009) Jun Lu et al.   FASEB JOURNAL

Human-specific induction of glutathione peroxidase-3 by proteasome inhibition in cardiovascular cells

(2009) Kera Westphal et al.   FREE RADICAL BIOLOGY AND MEDICINE

Selenium and diabetes: an enigma?

(2009) Andreas S. Mueller et al.   FREE RADICAL RESEARCH

Selenium Status and the Risk of Esophageal and Gastric Cancer Subtypes: The Netherlands Cohort Study

(2009) Jessie Steevens et al.   GASTROENTEROLOGY

Short Form Glutathione Peroxidase 4 Is the Essential Isoform Required for Survival and Somatic Mitochondrial Functions

(2009) Hanyu Liang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Common Variation in theDIO2Gene Predicts Baseline Psychological Well-Being and Response to Combination Thyroxine Plus Triiodothyronine Therapy in Hypothyroid Patients

(2009) Vijay Panicker et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Dietary selenium requirements based on tissue selenium concentration and glutathione peroxidase activities in old female rats

(2009) Roger A. Sunde et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

Is there a role for thyroid hormone on spermatogenesis?

(2009) Marcia Santos Wagner et al.   MICROSCOPY RESEARCH AND TECHNIQUE

Eukaryotic Initiation Factor 4a3 Is a Selenium-Regulated RNA-Binding Protein that Selectively Inhibits Selenocysteine Incorporation

(2009) Michael E. Budiman et al.   MOLECULAR CELL

Four selenoproteins, protein biosynthesis, and Wnt signalling are particularly sensitive to limited selenium intake in mouse colon

(2009) Anna Kipp et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Mouse Models Targeting Selenocysteine tRNA Expression for Elucidating the Role of Selenoproteins in Health and Development

(2009) Bradley Carlson et al.   MOLECULES

Novel insights into thyroid hormones from the study of common genetic variation

(2009) Colin M. Dayan et al.   Nature Reviews Endocrinology

Novel structural determinants in human SECIS elements modulate the translational recoding of UGA as selenocysteine

(2009) Lynda Latrèche et al.   NUCLEIC ACIDS RESEARCH

Osteo-Chondroprogenitor–Specific Deletion of the Selenocysteine tRNA Gene, Trsp, Leads to Chondronecrosis and Abnormal Skeletal Development: A Putative Model for Kashin-Beck Disease

(2009) Charlene M. Downey et al.   PLoS Genetics

GPx2 Counteracts PGE2 Production by Dampening COX-2 and mPGES-1 Expression in Human Colon Cancer Cells

(2008) Antje Banning et al.   ANTIOXIDANTS & REDOX SIGNALING

Peroxides and Peroxide-Degrading Enzymes in the Thyroid

(2008) Ulrich Schweizer et al.   ANTIOXIDANTS & REDOX SIGNALING

Serum Selenium Levels and All-Cause, Cancer, and Cardiovascular Mortality Among US Adults

(2008) Joachim Bleys   ARCHIVES OF INTERNAL MEDICINE

Hepatic selenoprotein P (SePP) expression restores selenium transport and prevents infertility and motor-incoordination inSepp-knockout mice

(2008) Kostja Renko et al.   BIOCHEMICAL JOURNAL

Serum Total Selenium Status in Greek Adults and Its Relation to Age. The ATTICA Study Cohort

(2008) Sophia Letsiou et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Selenium status highly regulates selenoprotein mRNA levels for only a subset of the selenoproteins in the selenoproteome

(2008) Roger A. Sunde et al.   BIOSCIENCE REPORTS

Variation in the Selenoenzyme Genes and Risk of Advanced Distal Colorectal Adenoma

(2008) U. Peters et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Interaction between Single Nucleotide Polymorphisms in Selenoprotein P and Mitochondrial Superoxide Dismutase Determines Prostate Cancer Risk

(2008) M. L. Cooper et al.   CANCER RESEARCH

Glutathione Peroxidase 4 Senses and Translates Oxidative Stress into 12/15-Lipoxygenase Dependent- and AIF-Mediated Cell Death

(2008) Alexander Seiler et al.   Cell Metabolism

Selenium Compounds and Selenoproteins in Cancer

(2008) Regina Brigelius-Flohé   CHEMISTRY & BIODIVERSITY

Molecular Basis for the Role of Selenium in Muscle Development and Function

(2008) Alain Lescure et al.   CHEMISTRY & BIODIVERSITY

Molecular mechanisms for hyperinsulinaemia induced by overproduction of selenium-dependent glutathione peroxidase-1 in mice

(2008) X. D. Wang et al.   DIABETOLOGIA

Cellular and Molecular Basis of Deiodinase-Regulated Thyroid Hormone Signaling1

(2008) Balázs Gereben et al.   ENDOCRINE REVIEWS

Thiol chemistry and specificity in redox signaling

(2008) Christine C. Winterbourn et al.   FREE RADICAL BIOLOGY AND MEDICINE

Thioredoxin reductase 1 haplotypes modify familial amyotrophic lateral sclerosis onset

(2008) John Mitchell et al.   FREE RADICAL BIOLOGY AND MEDICINE

Selenoprotein P expression is controlled through interaction of the coactivator PGC-1α with FoxO1a and hepatocyte nuclear factor 4α transcription factors

(2008) Bodo Speckmann et al.   HEPATOLOGY

Identification of DIO2 as a new susceptibility locus for symptomatic osteoarthritis

(2008) Ingrid Meulenbelt et al.   HUMAN MOLECULAR GENETICS

A mutation in theSEPN1selenocysteine redefinition element (SRE) reduces selenocysteine incorporation and leads toSEPN1-related myopathy

(2008) Baijayanta Maiti et al.   HUMAN MUTATION

Eukaryotic selenoprotein synthesis: Mechanistic insight incorporating new factors and new functions for old factors

(2008) Jeffrey E. Squires et al.   IUBMB LIFE

Effect of Selenium and Vitamin E on Risk of Prostate Cancer and Other Cancers

(2008) Scott M. Lippman et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

MsrB1(Methionine-R-sulfoxide Reductase 1) Knock-out Mice

(2008) Dmitri E. Fomenko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selenoproteins

(2008) Jun Lu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transcript Analysis of the Selenoproteome Indicates That Dietary Selenium Requirements of Rats Based on Selenium-Regulated Selenoprotein mRNA Levels Are Uniformly Less Than Those Based on Glutathione Peroxidase Activity

(2008) Kimberly M. Barnes et al.   JOURNAL OF NUTRITION

Redox Regulation of Protein Tyrosine Phosphatase 1B by Manipulation of Dietary Selenium Affects the Triglyceride Concentration in Rat Liver

(2008) Andreas S. Mueller et al.   JOURNAL OF NUTRITION

Regulation of the insulin antagonistic protein tyrosine phosphatase 1B by dietary Se studied in growing rats

(2008) Andreas S. Mueller et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

The gastrointestinal microbiota affects the selenium status and selenoprotein expression in mice

(2008) Juliane Hrdina et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Organoselenium Compounds in Cancer Chemoprevention

(2008) Rajesh Naithani   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Think globally: Act locally

(2008) Ulrich Schweizer et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Selenoprotein deficiency enhances radiation-induced micronuclei formation

(2008) Manjeshwar S. Baliga et al.   MOLECULAR NUTRITION & FOOD RESEARCH

The influence of selenium on immune responses

(2008) Peter R. Hoffmann et al.   MOLECULAR NUTRITION & FOOD RESEARCH

The use of the comet assay in the study of human nutrition and cancer

(2008) G. R. Wasson et al.   MUTAGENESIS

The Role of Selenium in Chronic Disease

(2008) Maria G. Boosalis   NUTRITION IN CLINICAL PRACTICE

The Role of Thioredoxin Reductases in Brain Development

(2008) Jonna Soerensen et al.   PLoS One

Articular cartilage metabolism in patients with Kashin–Beck Disease: an endemic osteoarthropathy in China

(2007) J. Cao et al.   OSTEOARTHRITIS AND CARTILAGE

Role of Promoter Polymorphisms in the Plasma Glutathione Peroxidase ( GPx-3 ) Gene as a Risk Factor for Cerebral Venous Thrombosis

(2007) Barbara Voetsch et al.   STROKE