Review
Endocrinology & Metabolism
Deborah Simao Souza, Carla Macheroni, Gustavo Jose Silva Pereira, Carolina Meloni Vicente, Catarina Segreti Porto
Summary: Prostate cancer is the most common cancer among men worldwide, and hormone-related factors, such as androgens, estrogens, and their receptors, play a crucial role in its development and progression. Galectin-3, a family of proteins, is involved in various stages of tumor development and progression, but its expression regulation is still poorly understood. This review focuses on the interplay between Galectin-3 and estrogen receptor signaling pathways in prostate cancer cells and proposes a molecular mechanism involving ER, Galectin-3, and beta-catenin in the modulation of nuclear transcriptional events. Further understanding of the role of Galectin-3 and ER in prostate cancer could lead to the discovery of new drug targets to treat castration-resistant prostate cancer.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ding-Xi Liu, Shuang-Li Hao, Wan-Xi Yang
Summary: This study investigates the mechanism of maintaining balance between cell adhesion and signal regulation by focusing on the role of β-CATENIN. The study deepens the understanding of the Wnt/β-CATENIN signaling pathway through exploring β-CATENIN chaperone molecules, phosphorylation, epithelial mesenchymal transition, and their connection to disease.
DNA AND CELL BIOLOGY
(2023)
Article
Virology
Xiao Zhang, Aowei Zhang, Xi Zhang, Shiyue Hu, Zhenghao Bao, Yuhao Zhang, Xiaoyan Jiang, Hongpeng He, Tong-Cun Zhang
Summary: In cervical cancer cells, ER alpha and ER alpha-36 have antagonistic effects on the expression of HPV E6/E7. ER alpha-36 promotes cell proliferation, migration, and invasion, while ER alpha inhibits these processes. This suggests that targeting ER alpha-36 with selective antagonists may be a promising strategy for cervical cancer therapy.
Article
Biochemistry & Molecular Biology
Jaewoong Jang, Jaewon Song, Hyunji Lee, Inae Sim, Young Kwon, Eek-hoon Jho, Yoosik Yoon
Summary: The study investigated the effect of LGK974, a Wnt signaling inhibitor, in mice with LPS-induced endotoxemia and found that LGK974 significantly increased survival rates and reduced plasma cytokine levels. Transcriptome analysis revealed changes in gene expression related to Wnt pathway, cytokines, and NF-kappa B signaling during endotoxemia. LGK974 treatment suppressed NF-kappa B signaling activation and cytokine expression in the liver, indicating a potential crosstalk between Wnt/beta-catenin and NF-kappa B pathways.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Young Yun Jung, Jae-Young Um, Arunachalam Chinnathambi, Chandramohan Govindasamy, Acharan S. Narula, Ojas A. Namjoshi, Bruce E. Blough, Gautam Sethi, Kwang Seok Ahn
Summary: This study investigated the effects of Withaferin A (WFA) on apoptosis and autophagy in human colorectal cancer cells. The results showed that WFA could induce cell cycle arrest, increase apoptotic cell death, and activate autophagy. The WFA-induced effects on apoptosis and autophagy were mediated through the modulation of the beta-catenin pathway.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Neurosciences
Ana M. Hernandez-Vega, Ignacio Camacho-Arroyo
Summary: The study demonstrates that E2 and TGF-β signaling pathways interact through ER-α and Smad2/3 mediators in human GBM cells and inhibit EMT activation induced by both factors alone.
Article
Oncology
Fei Yue, Weiyu Jiang, Amy T. Ku, Adelaide I. J. Young, Weijie Zhang, Eric P. Souto, Yankun Gao, Zihan Yu, Yi Wang, Chad J. Creighton, Chandandeep Nagi, Tao Wang, Susan G. Hilsenbeck, Xin-Hua Feng, Shixia Huang, Cristian Coarfa, Xiang H-F Zhang, Qingyun Liu, Xia Lin, Yi Li
Summary: The mechanism by which LGR4 promotes cancer metastasis is independent of the Wnt signaling pathway and involves interaction with EGFR to block its degradation, leading to increased migration and invasion of cancer cells.
Article
Genetics & Heredity
Cuifen Li, Manli Xie, Weiwei Wang, Yanyan Liu, Dan Liao, Jingwen Yin, Hao Huang
Summary: This study is the first and most comprehensive investigation of the association between ERs and depression in women, and the findings support the concept that ERs participate in the etiology of sex heterogeneity in depression.
FRONTIERS IN GENETICS
(2022)
Article
Food Science & Technology
Baocai Xie, Dengke Pan, Huan Liu, Min Liu, Xiaochen Shi, Xinyi Chu, Junfeng Lu, Mengqing Zhu, Bo Xia, Jiangwei Wu
Summary: Diosmetin treatment can reduce body weight and fat mass, improve glucose tolerance and insulin resistance by increasing energy expenditure through enhancing thermogenesis and browning of adipose tissue. Mechanistically, diosmetin acts as an agonist for estrogen receptors (ERs) to elevate their expression in adipose tissue, and the presence of ERs is essential for the metabolic benefits of diosmetin.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Philippe Aretz, Donata Maciaczyk, Suad Yusuf, Rudiger V. Sorg, Daniel Haenggi, Hongjia Liu, Hongde Liu, Tikam Chand Dakal, Amit Sharma, Ramakrishna Bethanabatla, Silke Neumann, Jarek Maciaczyk
Summary: The study reveals the crucial role of beta-catenin in attracting monocytes towards GBM cells and suggests that the interaction between beta-catenin and CCL2 may contribute to the maintenance of GSCs by modulating immune cell interaction and promoting GBM growth and recurrence.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Zhongqin Gong, Shucai Yang, Minghui Wei, Alexander C. Vlantis, Jason Y. K. Chan, C. Andrew van Hasselt, Dongcai Li, Xianhai Zeng, Lingbin Xue, Michael C. F. Tong, George G. Chen
Summary: Thyroid cancer is more common in women, suggesting a potential role of sex hormones in its development. Estrogen receptors alpha and beta have been found to play an important role in the pathogenesis of thyroid cancer. However, the expression and function of different isoforms of these receptors in thyroid cancer are still not well understood. This review aims to summarize the expression and roles of estrogen receptor alpha and beta isoforms in thyroid cancer, providing new insights into modulating their alternative RNA splicing against thyroid cancer.
FRONTIERS IN ONCOLOGY
(2022)
Review
Chemistry, Medicinal
Cristina Trejo-Solis, Angel Escamilla-Ramirez, Dolores Jimenez-Farfan, Rosa Angelica Castillo-Rodriguez, Athenea Flores-Najera, Arturo Cruz-Salgado
Summary: The Wnt/β-catenin signaling pathway plays crucial roles in various cancer types, affecting cell survival, proliferation, angiogenesis, migration, invasion, metastasis, and stem cell renewal. However, the pathway can have dual effects, promoting both cell proliferation and apoptosis depending on the cellular context. Understanding the mechanisms behind these effects could lead to new therapeutic opportunities in cancer treatment.
Article
Immunology
Xiaoyue Guan, Yani He, Zhichen Wei, Chen Shi, Yingxue Li, Rui Zhao, Lifei Pan, Yue Han, Tiezhou Hou, Jianmin Yang
Summary: The crosstalk between Wnt3a/beta-catenin and NF-kappa B signaling pathways plays a crucial role in the development of apical periodontitis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Clinical Neurology
Rhonda Voskuhl, Jens Kuhle, Prabha Siddarth, Noriko Itoh, Kevin Patel, Allan MacKenzie-Graham
Summary: Estrogens, depending on type, dose, and timing, have shown neuroprotective effects in both preclinical models and women during health and disease. In this study, oral administration of estriol, a unique estrogen during pregnancy, at a dose of 8 mg, reduced serum neurofilament light chain in nonpregnant women with multiple sclerosis, suggesting a potential protective role in neuro-axonal injury. This study supports the use of serum neurofilament light chain as a biomarker in multiple sclerosis.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2022)
Article
Biology
Carolina Franco Nitta, Ellen W. Green, Elton D. Jhamba, Justine M. Keth, Irais Ortiz-Caraveo, Rachel M. Grattan, David J. Schodt, Aubrey C. Gibson, Ashwani Rajput, Keith A. Lidke, Bridget S. Wilson, Mara P. Steinkamp, Diane S. Lidke
Summary: Crosstalk between EGFR and RON is unidirectional, with EGFR phosphorylating RON to activate RON-directed signaling, which requires the formation of a signaling competent EGFR dimer. Nanoscale imaging reveals association of EGFR and RON in common plasma membrane microdomains, while two-color single particle tracking captures the formation of complexes between RON and EGF-bound EGFR.