Review
Pharmacology & Pharmacy
Patrick Hawker, Li Zhang, Lu Liu
Summary: Inflammatory bowel disease (IBD) is a chronic condition characterized by persistent inflammation of the gastrointestinal tract. The cause of IBD is unknown and many patients are unresponsive to medication. Understanding the immunopathogenesis of IBD is crucial for determining its cause and improving treatments.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Zhenhua Qi, Weiqiang Zhong, Boyu Jiao, Kang Chen, Xiaohua Yang, Linjie Wang, Weian Zeng, Junting Huang, Jingdun Xie
Summary: G-protein-coupled receptor 183 regulates inflammatory pain by upregulating CCL22 in macrophages, and blocking this process can alleviate pain hypersensitivity.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Microbiology
Peng-Peng Wang, Xuefeng Jiang, Liying Zhu, Dan Zhou, Mingyang Hong, Lu He, Lumeng Chen, Shijie Yao, Yan Zhao, Guang Chen, Chengqi Wang, Liwang Cui, Yaming Cao, Xiaotong Zhu
Summary: GPR180 is involved in signal transduction during gametogenesis in malaria parasites and its deletion impairs gametogenesis and reduces transmission to mosquitoes.
MICROBIOLOGY SPECTRUM
(2022)
Review
Biochemistry & Molecular Biology
Juan Antonio Gimenez-Bastida, Antonio Gonzalez-Sarrias, Jose Moises Laparra-Llopis, Claus Schneider, Juan Carlos Espin
Summary: Dietary (poly)phenols demonstrate anti-inflammatory effects by targeting the 5-LOX pathway, although research in this area is limited and requires further exploration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Yaoyao Du, Jie Chen, Lan Shen, Bing Wang
Summary: This article reviews the potential roles of transient receptor potential (TRP) channels in inflammatory bowel disease (IBD). TRP channels are widely distributed in the gastrointestinal tract and visceral sensory nervous systems and play various roles in physiological and pathological processes. Studies have shown that TRP channels could be novel drug targets for treating IBD.
BIOCHEMICAL PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Alfredo Ulloa-Aguirre, Teresa Zarinan, Eduardo Jardon-Valadez
Summary: This review discusses the mechanisms by which mutations in GPCRs involved in endocrine function in humans lead to misfolding, decreased plasma membrane expression of the receptor protein, and loss-of-function diseases. Special attention is given to misfolded GPCRs that regulate reproductive function, and promising therapeutic interventions targeting trafficking of these defective proteins to rescue their normal function are also described.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Haoran Jiang, Daniella Galtes, Jialu Wang, Howard A. Rockman
Summary: This review explores the signaling pathways, dynamic structures, and physiological relevance of the three most important GPCR signaling effectors in the cardiovascular system: heterotrimeric G proteins, GPCR kinases (GRKs), and 8-arrestins. It summarizes their prominent roles in GPCR pharmacology before transitioning into less well-explored areas. The application of new technologies has contributed to an increasing understanding of GPCR structure and downstream effectors.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
J. Thomas Brenna, Marina G. Sergeeva, Nikolay B. Pestov, Tatyana V. Korneenko, Mikhail S. Shchepinov
Summary: This article discusses a new approach, using oxidation-resistant hexadeuterated arachidonic acid (D-ARA), to attenuate pathological inflammatory reactions by buffering the eicosanoid pathways. Enzymatic processing of released arachidonic acid by phospholipase A2 yields bioactive eicosanoids, some of which have pro-inflammatory, pro-angiogenesis, and pro-thrombosis effects. D-ARA, resistant to both enzymatic and non-enzymatic oxidation pathways, may play a role in mitigating inflammation-related disorders.
FREE RADICAL RESEARCH
(2023)
Article
Chemistry, Analytical
Cai-Feng Xiong, Quan-Fei Zhu, Yao-Yu Chen, Dong-Xiao He, Yu-Qi Feng
Summary: In this study, a highly sensitive and specific method for screening and annotating epoxy/dihydroxy-oxylipins in biological samples was established using chemical labeling-assisted liquid chromatography coupled with high-resolution mass spectrometry. The analysis revealed the presence of potential epoxy/dihydroxy-oxylipins, including previously unreported compounds, in human serum and high-fat diet mouse heart samples. Moreover, the method showed a significant decrease in the levels of certain epoxy/dihydroxy-oxylipins in the heart of mice with high-fat diet, particularly those derived from linoleic acid or alpha-linolenic acid.
ANALYTICAL CHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Estefania Moreno, Nil Casajuana-Martin, Michael Coyle, Baruc Campos Campos, Ewa Galaj, Claudia Llinas del Torrent, Arta Seyedian, William Rea, Ning-Sheng Cai, Alessandro Bonifazi, Benjamin Floran, Zheng-Xiong Xi, Xavier Guitart, Vicent Casado, Amy H. Newman, Christopher Bishop, Leonardo Pardo, Sergi Ferre
Summary: This study provides evidence that heteromerization of G protein-coupled receptors (GPCRs), specifically dopamine D1 and D3 receptors, can influence the pharmacological properties of selective ligands. In vivo experiments support the involvement of D1R-D3R heteromers in the development of L-DOPA-induced dyskinesia in Parkinson's disease, suggesting the potential of targeting GPCR heteromers for drug development.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Juergen Einsiedel, Maximilian F. Schmidt, Harald Huebner, Peter Gmeiner
Summary: A broadly applicable synthesis method was developed for peptides incorporating mixed disulfides between cysteine and homocysteine and cysteamine. The method was successfully applied to pharmacologically relevant GPCR ligands and showed covalent binding to neurotensin receptor 1 in a radioligand depletion study.
BIOORGANIC & MEDICINAL CHEMISTRY
(2022)
Review
Pharmacology & Pharmacy
Bui San Thai, Ling Yeong Chia, Anh T. N. Nguyen, Chengxue Qin, Rebecca H. Ritchie, Dana S. Hutchinson, Andrew Kompa, Paul J. White, Lauren T. May
Summary: Heart failure remains a significant cause of morbidity and mortality worldwide. Current treatment options have limitations, leading to many patients progressing to advanced stages. Exploration of novel therapeutics targeting G protein-coupled receptors (GPCRs) has shown promise, but efficacy and unwanted effects remain as challenges.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Georg Gruenbacher, Hubert Gander, Gabriele Dobler, Andrea Rahm, Dominik Klaver, Martin Thurnher
Summary: The study used transcriptome and secretome profiling to analyze the signaling and function of ectopic P2Y(11) receptors, which were validated in human monocyte-derived M2 macrophages. The results showed that targeting P2Y(11) receptors can activate IL-1 receptor signaling to promote sTNFR2 release and suppress TLR4 signaling, facilitating resolution of inflammation.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Review
Pharmacology & Pharmacy
Mydirah Littlepage-Saunders, Michael J. Hochstein, Doris S. Chang, Kari A. Johnson
Summary: Dopamine transmission in the striatum is regulated by various G protein-coupled receptors (GPCRs) that bind neuromodulators, including dopamine itself. These GPCRs can modulate dopamine release by acting on different components of the dopaminergic circuitry and can have distinct effects on behavior and psychoactive drug actions. This review discusses the mechanisms by which GPCRs regulate dopaminergic transmission and their relevance to the effects of psychoactive drugs on physiology and behavior.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Fisheries
Yangguang Bao, Yuedong Shen, Zhaoxun Wu, Shunshun Tao, Bingqian Yang, Tingting Zhu, Wenli Zhao, Yingying Zhang, Xiaoyi Zhao, Lefei Jiao, Ziyi Wang, Qicun Zhou, Min Jin
Summary: In this study, an eight-week feeding trial was conducted to evaluate the regulatory effects of dietary Arachidonic acid (ARA) and its metabolites on inflammation, oxidative stress, and apoptosis in Acanthopagrus schlegelii. Results showed that high levels of dietary ARA induced inflammation by activating the gene expression levels of nuclear factor kappa B (nf-kappa b) and oxidative stress by reducing antioxidant parameters. Additionally, excess ARA levels promoted cell apoptosis by up-regulating pro-apoptotic gene expression levels.
AQUACULTURE REPORTS
(2023)
Article
Chemistry, Multidisciplinary
Takuya Yanagisawa, Takumi Misaka
Summary: This study investigated the bitterness of sesquiterpene lactones in Asteraceae species and found that adjusting the pH can reduce the response of bitter taste receptors, providing a potential method for regulating the bitterness of these vegetables.
Article
Biochemistry & Molecular Biology
Yuri Hayashi, Hyeon-Cheol Lee-Okada, Eri Nakamura, Norihiro Tada, Takehiko Yokomizo, Yoko Fujiwara, Ikuyo Ichi
Summary: This study found that >= C20 PUFAs synthesized by FADS2 are crucial in regulating hepatic triacylglycerol and cholesterol accumulation during PUFA deficiency.
Article
Multidisciplinary Sciences
Nanase Takahashi, Toshiaki Okuno, Hiroki Fujii, Shintaro Makino, Masaya Takahashi, Mai Ohba, Kazuko Saeki, Atsuo Itakura, Satoru Takeda, Takehiko Yokomizo
Summary: The study revealed that the production of PGE(2) in fetal-membrane is influenced by COXs, cPGES, and SLCO2A1, which play roles in the accumulation of PGE(2) in amniotic fluid.
Editorial Material
Dermatology
Kahbing Jasmine Tan, Satoshi Nakamizo, Hyeon-Cheol Lee-Okada, Reiko Sato, Zachary Chow, Saeko Nakajima, John E. A. Common, Kazuko Saeki, Takehiko Yokomizo, Florent Ginhoux, Kenji Kabashima
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Nutrition & Dietetics
Kenji Uchida, Mina Fujitani, Takafumi Mizushige, Fuminori Kawabata, Kohsuke Hayamizu, Keisuke Uozumi, Yuma Hara, Mariko Sawai, Ryota Uehigashi, Shinji Okada, Naoko Goto-Inoue, Mizuki Morisasa, Taro Kishida
Summary: This study found that dietary intake of Alaska pollack protein (APP) can induce acute and sustainable skeletal muscle hypertrophy in rats, regardless of dietary fat content. APP can be an approach for maintaining or increasing muscle mass.
Article
Biochemistry & Molecular Biology
Yoko Hoshino, Toshiaki Okuno, Daisuke Saigusa, Kuniyuki Kano, Shota Yamamoto, Hideo Shindou, Junken Aoki, Kanji Uchida, Takehiko Yokomizo, Nobuko Ito
Summary: The study revealed the significant role of the LPA-LPA(1) signaling pathway in acute nociceptive pain, particularly in modulating neuronal sensitivity and pain behavior. The results indicate that LPA produced in innervated DRGs promotes the activation of SGCs, increasing neuronal sensitivity, and modulating pain behavior.
Article
Multidisciplinary Sciences
Miho Asahara, Nobuko Ito, Yoko Hoshino, Takaharu Sasaki, Takehiko Yokomizo, Motonao Nakamura, Takao Shimizu, Yoshitsugu Yamada
Summary: The study examined the role of LTB4-BLT1 signaling in postoperative incisional pain and found that LTB4 exacerbates pain responses through promoting local infiltration of inflammatory monocytes and cytokine production. Therefore, LTB4-BLT1 signaling could be a potential therapeutic target for acute and persistent pain induced by tissue injury.
Article
Biochemistry & Molecular Biology
Ryotaro Shioda, Airi Jo-Watanabe, Toshiaki Okuno, Kazuko Saeki, Maiko Nakayama, Yusuke Suzuki, Takehiko Yokomizo
Summary: Leukotriene B-4 (LTB4) and its receptor BLT1 are the key factors in the pathogenesis of crescentic glomerulonephritis, and targeting them may be a potential therapeutic strategy for this disease.
Article
Biochemistry & Molecular Biology
Ken Yasukawa, Toshiaki Okuno, Narihito Ogawa, Yuichi Kobayashi, Takehiko Yokomizo
Summary: This study reveals that 12-HHT is metabolized into 12-KHT and 10,11dh-12-KHT by 15-PGDH and PTGR1, respectively, without losing its agonistic activity on BLT2.
JOURNAL OF BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Ryusei Goda, Soichi Watanabe, Takumi Misaka
Summary: In vertebrates, nutritional tastants are recognized by taste receptor type 1 (T1R) family. Zebrafish and medaka fish have oral receptors highly sensitive to amino acids, especially l-proline. Functional assays confirmed the presence of specific T1Rs in these fish, reflecting the physiological importance of l-proline in teleosts.
Review
Immunology
Takehiko Yokomizo, Takao Shimizu
Summary: Leukotriene B-4 (LTB4) is a chemotactic factor for inflammatory cells derived from arachidonate, and an important drug target. The high-affinity LTB4 receptor, BLT1, is involved in the pathogenesis of various inflammatory and immune diseases. The low-affinity receptor, BLT2, is a receptor for 12-hydroxyheptadecatrienoic acid and is involved in maintaining barrier function and promoting wound healing. BLT1 antagonists and BLT2 agonists are potential candidates for treating inflammatory diseases.
IMMUNOLOGICAL REVIEWS
(2023)
Article
Physiology
Masataka Narukawa, Rina Matsuda, Ippei Watari, Takashi Ono, Takumi Misaka
Summary: In this study, we investigated the effect of decreased salivary secretion on taste preference using a mouse model. We found that saliva is necessary to maintain normal taste preference, and changes in protein concentration and composition in the saliva may contribute to the changes in taste preferences observed in the desalivated mice.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Tomoya Nakagita, Takumi Matsuya, Masataka Narukawa, Takuya Kobayashi, Takatsugu Hirokawa, Takumi Misaka
Summary: This study created a docked model of the transmembrane domain (TMD) of the T1R3 subunit of the human sweet taste receptor with neohesperidin dihydrochalcone (NHDC) and identified important residues for NHDC recognition. The docking mode of NHDC with T1R3 TMD was distinct from that of lactisole, a sweet taste inhibitor.
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Yoichi Kasahara, Masataka Narukawa, Shinji Kanda, Makoto Tominaga, Keiko Abe, Takumi Misaka, Tomiko Asakura
Summary: Human susceptibility to NaCl is influenced by temperature and pH, with TMC4 playing a potential role in human salt taste reception due to its activation at 40 degrees C and suppression at pH 5.5, which are similar to human sensory evaluations.
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Hyeon-Cheol Lee-Okada, Kotaro Hama, Kazuaki Yokoyama, Takehiko Yokomizo
Summary: This study introduces a strategy for measuring FFAs in complex biological samples, using key methods such as isocratic LC separation, postcolumn base addition, and pseudo-multiple reaction monitoring. The method enables the measurement of various FFA species, including ultra-long-chain fatty acids.
JOURNAL OF BIOCHEMISTRY
(2021)
