Review
Immunology
Chao Yang, Dan Li, Dehong Teng, Yueru Zhou, Lei Zhang, Zhangfeng Zhong, Guan-Jun Yang
Summary: This review discusses the research on the pathogenesis of rheumatoid arthritis (RA) in the past five years based on epigenetic modifications, providing new methods and strategies for the diagnosis and treatment of this disease.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Oncology
Ryo Shiraishi, Daisuke Kawauchi
Summary: Recent studies have classified medulloblastoma into four molecular subgroups, each with distinct oncogenic drivers and cellular origins. Understanding the molecular signals driving tumorigenesis is still lacking, necessitating further research into the etiology of tumors to establish effective treatment strategies.
Review
Immunology
Cen Chang, Lingxia Xu, Runrun Zhang, Yehua Jin, Ping Jiang, Kai Wei, Linshuai Xu, Yiming Shi, Jianan Zhao, Momiao Xiong, Shicheng Guo, Dongyi He
Summary: MicroRNAs (miRNAs) play crucial roles in the pathogenesis, diagnosis, and therapeutic intervention of rheumatoid arthritis (RA). They regulate gene expression, immune system differentiation, and serve as potential biomarkers and therapeutic targets.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Ruo-Nan Zhang, Zhi-Qian Jing, Lu Zhang, Zhi-Jun Sun
Summary: Immune checkpoint blockade therapy has revolutionized cancer treatment by providing durable responses in advanced and metastatic cancers. However, immune suppressive cells and molecules in the tumor microenvironment can hinder the efficacy of immune checkpoint inhibitors. Pyroptosis, a type of programmed cell death, can transform "cold" tumors to "hot" tumors, enhancing the immune response and preventing tumor growth. Recent evidence suggests that epigenetic regulation of pyroptosis could be a promising therapeutic strategy. This review discusses the mechanism of pyroptosis and summarizes the role of three common epigenetic factors in regulating pyroptosis in cancer. Targeting epigenetic regulation of pyroptosis could provide new insights and advances in cancer therapy.
Article
Oncology
Mahendra Pratap Kashyap, Rajesh Sinha, M. Shahid Mukhtar, Mohammad Athar
Summary: Advancements in cutting-edge technological tools and bioinformatics have revolutionized the understanding and research of cancer. This review focuses on the epigenetic regulation of non-melanoma skin cancer, emphasizing the roles of genetic mutations, epigenetic regulation, and novel therapeutic interventions in cancer progression.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Oncology
Reem Khaled M. E. Alsayed, Abdul Q. Khan, Fareed Ahmad, Abdul Wahid Ansari, Majid Ali Alam, Jorg Buddenkotte, Martin Steinhoff, Shahab Uddin, Aamir Ahmad
Summary: The signaling involving chemokine receptor CXCR4 and its ligand SDF-1/CXL12 has been studied in relation to cancer progression and pathogenesis, with evidence supporting its diagnostic and prognostic importance. Epigenetic regulation, including non-coding RNAs and methylation/acetylation, plays a key role in the upregulation of CXCR4 in primary and metastatic cancers.
SEMINARS IN CANCER BIOLOGY
(2022)
Review
Immunology
Fan Xiao, Ke Rui, Xiaofei Shi, Haijing Wu, Xiaoyan Cai, Kathy O. Lui, Qianjin Lu, Esteban Ballestar, Jie Tian, Hejian Zou, Liwei Lu
Summary: B cells play a crucial role in autoimmune diseases, and epigenetic research has revealed new mechanisms leading to B cell hyperactivation. Dysregulation of epigenetic mechanisms may contribute to the pathogenesis of autoimmune diseases.
CELLULAR & MOLECULAR IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Kajetan Kielbowski, Mariola Herian, Estera Bakinowska, Boleslaw Banach, Tomasz Sroczynski, Andrzej Pawlik
Summary: Osteoarthritis (OA) is a progressive disease characterized by cartilage degradation, subchondral bone remodelling, and inflammation of the synovium. The disease is associated with obesity, mechanical load, and age. Multiple pro-inflammatory immune mediators regulate the expression of metalloproteinases involved in cartilage degradation. In addition, genetic factors and epigenetic mechanisms play a role in the susceptibility and pathogenesis of OA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Bianca Vezzani, Marianna Carinci, Maurizio Previati, Stefania Giacovazzi, Mario Della Sala, Roberta Gafa, Giovanni Lanza, Mariusz R. Wieckowski, Paolo Pinton, Carlotta Giorgi
Summary: Epigenetics refers to a group of dynamic, reversible, and heritable modifications within cells that are not caused by gene mutations. These modifications are highly influenced by the surrounding environment and the internal microenvironments of tissues and cells. Understanding the interaction between the tumor microenvironment and cancer cells in terms of epigenetic networks may reveal new targetable mechanisms to prevent tumor progression.
Article
Oncology
Diego M. Avella Patino, Vijay Radhakrishnan, Kanve N. Suvilesh, Yariswamy Manjunath, Guangfu Li, Eric T. Kimchi, Kevin F. Staveley-O'Carroll, Wesley C. Warren, Jussuf T. Kaifi, Jonathan B. Mitchem
Summary: This review article summarizes the role of epigenetic regulation in immune response in a wide range of cancers, including the epigenetic changes in immune cells such as T cells, macrophages, and natural killer cells.
SEMINARS IN CANCER BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Irina Bure, Marina Nemtsova, Ekaterina B. Kuznetsova
Summary: In recent years, scientists have increasingly suggested and confirmed that epigenetic regulators are closely linked and form a comprehensive network of regulatory pathways and feedback loops. This is particularly important for a better understanding of the development and progression of various diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Fang Wang, Greg Malnassy, Wei Qiu
Summary: This article summarizes the current understanding of epigenetic regulation in the HCC microenvironment and reviews recent studies on the role of specific epigenetic mechanisms in HCC development.
FRONTIERS IN ONCOLOGY
(2021)
Article
Immunology
Ravesh Singh, Veron Ramsuran, Vivek Naranbhai, Nonhlanhla Yende-Zuma, Nigel Garrett, Koleka Mlisana, Krista L. Dong, Bruce D. Walker, Salim S. Abdool Karim, Mary Carrington, Thumbi Ndungu
Summary: Elevated levels of BST-2 may be associated with viral control in HIV-infected females, and DNA methylation plays a role in regulating BST-2 levels.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Rachel J. Kehrberg, Namita Bhyravbhatla, Surinder K. Batra, Sushil Kumar
Summary: Cancer-associated fibroblasts (CAFs), a significant component of the tumor microenvironment (TME), contribute to cancer progression through the secretion of extracellular matrix (ECM), growth factors, and metabolites. It is now well recognized that CAFs are a heterogenous population with ablation experiments leading to reduced tumor growth and single-cell RNA sequencing demonstrating CAF subgroups. CAFs lack genetic mutations yet substantially differ from their normal stromal precursors.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2023)
Article
Chemistry, Multidisciplinary
Jiahao Hu, Yuchan You, Luwen Zhu, Jucong Zhang, Yanling Song, Jingyi Lu, Xinyi Xu, Xiaochuan Wu, Xiajie Huang, Xiaoling Xu, Yongzhong Du
Summary: In this study, sialic acid-functionalized pyroptosis nanotuners are developed to improve the efficacy of immune checkpoint blockade therapy in tumors with low GSDME expression through epigenetic alteration and immunogenic cell death mechanism. The coloaded liposomes encapsulating decitabine and triclabendazole show promising synergistic effects in tumor immunotherapy.
Article
Substance Abuse
Luis R. Vaz, Paul Aveyard, Sue Cooper, Jo Leonardi-Bee, Tim Coleman
NICOTINE & TOBACCO RESEARCH
(2016)
Article
Biochemistry & Molecular Biology
X. Mao, C. Gauche, M. W. H. Coughtrie, C. Bui, S. Gulberti, F. Merhi-Soussi, N. Ramalanjaona, I. Bertin-Jung, A. Diot, D. Dumas, N. De Freitas Caires, A. M. Thompson, J-C Bourdon, M. Ouzzine, S. Fournel-Gigleux
Article
Pharmacology & Pharmacy
Gurinder Walia, Alexander D. Smith, Zoe Riches, Abby C. Collier, Michael W. H. Coughtrie
Meeting Abstract
Pharmacology & Pharmacy
Zoe Riches, Gurinder Walia, Jacob Berman, Michael Coughtrie, Abby Collier
JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS
(2017)
Review
Pharmacology & Pharmacy
Yuejian Liu, MichaelW. H. Coughtrie
Article
Biochemistry & Molecular Biology
Zhe Xie, Mostafa Khair, Irfan Shaukat, Patrick Netter, Didier Mainard, Lydia Barre, Mohamed Ouzzine
CELL DEATH AND DIFFERENTIATION
(2018)
Article
Biochemistry & Molecular Biology
Marine Houdou, Elodie Lebredonchel, Anne Garat, Sandrine Duvet, Dominique Legrand, Valerie Decool, Andre Klein, Mohamed Ouzzine, Bruno Gasnier, Sven Potelle, Francois Foulquier
Article
Chemistry, Multidisciplinary
Alexander D. Smith, Brent D. G. Page, Abby C. Collier, Michael W. H. Coughtrie
Article
Cell Biology
Sajida Khan, Malak Sbeity, Francois Foulquier, Lydia Barre, Mohamed Ouzzine
Summary: TMEM165 deficiency leads to skeletal disorder characterized by skeletal dysplasia and dwarfism. The study found that TMEM165 deficiency impairs the synthesis of proteoglycans, resulting in shorter glycosaminoglycan chains. Additionally, TMEM165 deficiency affects TGF beta and BMP signaling pathways in chondrocytes and accelerates chondrogenic differentiation.
CELL DEATH & DISEASE
(2022)
Article
Cell Biology
Zoe Durin, Marine Houdou, Willy Morelle, Lydia Barre, Aurore Layotte, Dominique Legrand, Mohamed Ouzzine, Francois Foulquier
Summary: Glycosylation is a universal cellular process that can lead to severe genetic diseases. Oral D-Galactose therapy shows promise in treating specific CDG, while MnCl2 supplementation can fully rescue glycosylation defects caused by TMEM165 deficiency. However, D-Galactose only affects N-linked glycosylation while MnCl2 supplementation rescues all glycosylation types.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Michael J. J. Doerksen, Denny Seo, Alexander D. D. Smith, Robert S. S. Jones, Michael W. H. Coughtrie, Abby C. C. Collier
Summary: In this study, hepatic GST conjugation was investigated in mouse and rat strains compared to humans. The results showed that all mouse strains had higher activities of total cytosolic GST, GST-M, GST-T, and microsomal GST compared to humans, with some strains also having higher GST-P activities. Sex differences were observed in all strains for several GST activities. Similarly, rats exhibited higher activities of GST-M and GST-T compared to humans, with some strains also showing higher activities of GST-P, total cytosolic GST, and microsomal GST. Sex differences were also observed in some strains for certain GST activities. These findings highlight the importance of careful selection of animal models in pre-clinical studies where GSTs are involved in drug metabolism.
Article
Cell Biology
Mahdia Taieb, Dima Ghannoum, Lydia Barre, Mohamed Ouzzine
Summary: Genetic mutations in the Xylt1 gene are associated with Desbuquois dysplasia type II syndrome characterized by sever prenatal and postnatal short stature. The study reveals the specific role of XylT-I in the growth plate and its importance in the synthesis of proteoglycans.
CELL DEATH & DISEASE
(2023)
Article
Chemistry, Multidisciplinary
Isabelle Bertin-Jung, Anne Robert, Nick Ramalanjaona, Sandrine Gulberti, Catherine Bui, Jean-Baptiste Vincourt, Mohamed Ouzzine, Jean-Claude Jacquinet, Chrystel Lopin-Bon, Sylvie Fournel-Gigleux
CHEMICAL COMMUNICATIONS
(2020)
Article
Pharmacology & Pharmacy
Sjoerd de Hoogd, Pyry A. J. Valitalo, Albert Dahan, Simone van Kralingen, Michael M. W. Coughtrie, Eric P. A. van Dongen, Bert van Ramshorst, Catherijne A. J. Knibbe
CLINICAL PHARMACOKINETICS
(2017)