Review
Environmental Sciences
Jing Wei, Xinying Zhang, Longlong Xia, Wenping Yuan, Zhanyan Zhou, Nicolas Brueggmann
Summary: Evidence has shown that chemical reactions play a significant role in the terrestrial nitrogen cycle, contributing to N2O and NO emissions as well as N retention. Abiotic processes contribute substantially to global terrestrial N2O emission and retention, with factors such as pH, TOC, TN, C/N ratio, and transition metals influencing these reactions. This study expands our understanding of chemical N reactions and provides insights into their contribution to nitrogenous trace gas emission and N retention, contributing to the further study of interactions between biologically and chemically mediated reactions in the biogeochemical N cycle.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Engineering, Biomedical
Lingdong Jiang, Danyang Chen, Zhaokui Jin, Chao Xia, Qingqing Xu, Mingjian Fan, Yunlu Dai, Jia Liu, Yuanpei Li, Qianjun He
Summary: In this study, a peptide-based nanoparticle was developed for tumor-targeted delivery of nanomedicine. The nanoparticle could release nitric oxide (NO) and undergo structural transformation upon light irradiation, leading to enhanced intratumoral retention and sensitizing photodynamic therapy (PDT).
BIOACTIVE MATERIALS
(2022)
Article
Multidisciplinary Sciences
Hongyuan Zhang, Zhiqiang Zhao, Shengnan Sun, Sen Zhang, Yuequan Wang, Xuanbo Zhang, Jin Sun, Zhonggui He, Shenwu Zhang, Cong Luo
Summary: In this study, the authors developed a self-propelling nano-penetrator assembled with a photothermal photosensitizer and a photothermal-activable NO donor. The nano-penetrator showed advantages in terms of NO productivity and autonomous motion under laser irradiation. In animal models, it successfully navigated to thrombus, penetrated deep into the clot, and achieved effective thrombolysis and prevention of thrombosis recurrence and ischemic stroke.
NATURE COMMUNICATIONS
(2023)
Article
Engineering, Environmental
Seung-Woon Baek, Da-Seul Kim, Jun-Kyu Lee, Jun Hyuk Kim, Semi Lee, Jeong Min Park, So-Yeon Park, Duck Hyun Song, Chun Gwon Park, Dong Keun Han
Summary: A novel nanoparticle with enhanced nitric oxide (NO) generating ability was synthesized to improve the biodegradable vascular scaffold (BVS) intervention for coronary artery diseases. The BVS containing the synthesized nanoparticles demonstrated potent functional recovery ability of unhealthy vessels by inhibiting platelet adhesion and activation, increasing endothelial cell proliferation, and decreasing smooth muscle cell proliferation. The BVS also showed scavenging ability of reactive oxygen species and inhibition of toxic NO production, with suppressed inflammatory response and induced healthy blood vessel formation when implanted in mice. This offers a new tool for designing cardiovascular stents and various biological applications.
CHEMICAL ENGINEERING JOURNAL
(2023)
Review
Biochemistry & Molecular Biology
Amir Asgari, Paul Jurasz
Summary: Megakaryocytes are important members of the hematopoietic system, responsible for regulating vascular homeostasis through platelets. The process of megakaryopoiesis generates mature megakaryocytes which release proplatelets into blood vessels. Nitric oxide (NO) plays a modulatory role in hematopoiesis and hemostasis. This review summarizes the effect of NO and its signaling on megakaryopoiesis and thrombopoiesis under physiological and pathophysiological conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Maria Rosaria Melis, Antonio Argiolas
Summary: Nitric oxide plays a crucial role in the central nervous system, regulating erectile function and sexual behavior by interacting with neurotransmitters. It acts not only in specific areas of the hypothalamus, but also in extrahypothalamic brain regions, contributing to a neural circuit controlling both consummatory and appetitive components of sexual behavior through interplay with various neurotransmitters.
Article
Biochemistry & Molecular Biology
John Ukeri, Michael T. Wilson, Brandon J. Reeder
Summary: Cytoglobin has physiological roles that are not clearly understood, but may include regulation of nitric oxide, oxygen sensing, and protection against oxidative stress. Specific mutations can affect the nitric oxide binding and metabolism activities of cytoglobin, helping to understand its precise role under physiological and pathophysiological conditions.
Article
Chemistry, Multidisciplinary
Yanwen Zhang, Zefeng Wang, Mei Li, Can Xu, Ning Gao, Zhuping Yin, Kemin Wang, Stephen Mann, Jianbo Liu
Summary: The design and construction of synthetic protocells capable of stimuli response and homeostatic regulation is an important challenge for synthetic protobiology. In this study, we demonstrate a reconfigurable model protocell based on osmotic reconfiguration of lipid-coated coacervate droplets into multicompartmentalized coacervate vesicles that can exhibit hypotonic stress-induced volume response and enhance enzyme reactions. The increased nitric oxide (NO) within the swollen vesicles can induce blood vessel vasodilation, showing potential applications in biomedicine, cellular diagnostics, and bioengineering.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Medicine, Research & Experimental
Joao Victor Silva-Silva, Carla J. Moragas-Tellis, Maria S. S. Chagas, Paulo Victor R. Souza, Davyson L. Moreira, Celeste S. F. de Souza, Kerolain F. Teixeira, Arthur R. Cenci, Aldo S. de Oliveira, Fernando Almeida-Souza, Maria D. Behrens, Katia S. Calabrese
Summary: This study evaluated the leishmanicidal activity of a crude extract and anthocyanidin-rich fractions from Arrabidaea chica, as well as three isolated anthocyanidins. The results showed promising anti-leishmanial effects of these compounds, indicating their potential as therapeutic agents for leishmaniasis.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Editorial Material
Biochemistry & Molecular Biology
Henry Jay Forman
Summary: This invited paper addresses the question of whether the superoxide radical can exert deleterious effects independently of its participation with H2O2 in the production of the hydroxyl radical. The author, Irwin Fridovich, provides a correct affirmative answer, although subsequent research on peroxynitrite has added more complexity.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2022)
Review
Biochemistry & Molecular Biology
Jinghua Chen, Lulu Liu, Weiwei Wang, Haichun Gao
Summary: This article discusses the important role of nitric oxide in the microbe-driven nitrogen biogeochemical cycle, as well as its significance in medicine and the biological sciences. The article explores the importance of nitric oxide in early energy generation and its effects on various biological processes within bacterial physiology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Engineering, Biomedical
Jordan Beurton, Ariane Boudier, Amedea Barozzi Seabra, Nihal Engin Vrana, Igor Clarot, Philippe Lavalle
Summary: This article provides an overview of the design of nitric oxide (NO) delivering surfaces for biomedical purposes, focusing on the advances made in the past 5 years. The localized supply of NO is of interest due to its various biological effects. Depending on the generated NO flux, the surface can mimic physiological release profiles to provide activity on the vascular endothelium or antibacterial activity. The article emphasizes the importance of selecting the appropriate coating for the substrate, matching the kinetics of NO release/generation to the targeted biological application, and considering the biocompatibility and stability of the surface. It provides a critical perspective to assist readers in designing NO delivering surfaces according to their specific requirements and therapeutic purposes.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Medicine, Research & Experimental
George J. Dugbartey
Summary: Kidney transplantation is the preferred treatment for patients with kidney failure. However, ischemia-reperfusion injury (IRI) poses a significant challenge to the long-term success of this intervention. Nitric oxide (NO) has emerged as a potential candidate for mitigating IRI and preventing graft rejection in kidney transplantation. This review provides an overview of the sources and protective effects of endogenous and exogenous NO in kidney transplantation.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Multidisciplinary Sciences
Shixun Liu, Anming Xu, Bin Xie, Fengxue Xin, Weiliang Dong, Jie Zhou, Min Jiang
Summary: This study reveals the importance of c-di-GMP in coordinating the synthesis of biofilm exopolysaccharides and RLs in Pseudomonas aeruginosa. By comparing different strains and analyzing the genome, it is found that the regulation of c-di-GMP level is crucial for switching between these two synthesis processes.
Article
Pharmacology & Pharmacy
Tatsiana Suvorava, Sara Metry, Stephanie Pick, Georg Kojda
Summary: Vascular tone regulation by nitric oxide is a crucial physiological function, with endothelial dysfunction potentially being an underlying cause of hypertension. Increasing eNOS activity reduces blood pressure, while decreasing activity has the opposite effect. These findings have important implications for pre-hypertensive treatment.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Cell Biology
Eun Hee Ahn, Seong Su Kang, Xia Liu, Guiqin Chen, Zhentao Zhang, Bindu Chandrasekharan, Ashfaqul M. Alam, Andrew S. Neish, Xuebing Cao, Keqiang Ye
Article
Gastroenterology & Hepatology
Anais Larabi, Guillaume Dalmasso, Julien Delmas, Nicolas Barnich, Hang Thi Thu Nguyen
Article
Microbiology
Anais Larabi, Laurene Salesse, Charlotte Cordonnier, Lucie Etienne-Mesmin, Nicolas Barnich, Guillaume Dalmasso, Hang Thi Thu Nguyen
Review
Microbiology
Mickael Desvaux, Guillaume Dalmasso, Racha Beyrouthy, Nicolas Barnich, Julien Delmas, Richard Bonnet
FRONTIERS IN MICROBIOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Bindu Chandrasekharan, Claudia Montllor-Albalate, Alyson E. Colin, Joshua L. Andersen, Young C. Jang, Amit R. Reddi
Summary: Cu/Zn superoxide dismutase (Sod1) catalyzes the breakdown of superoxide radicals into oxygen and hydrogen peroxide, which acts as a signaling molecule. In yeast, Sod1 is involved in a redox signaling pathway that connects nutrient availability to energy metabolism control. This pathway stabilizes plasma membrane kinases Yck1/2, promoting glycolytic growth and repressing respiration.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Guillaume Dalmasso, Hang Thi Thu Nguyen, Tiphanie Fais, Sebastien Massier, Caroline Chevarin, Emilie Vazeille, Nicolas Barnich, Julien Delmas, Richard Bonnet
Summary: The study revealed that the yersiniabactin siderophore of AIEC provides an advantage for growth in competitive environments, but it also activates autophagy leading to bacterial clearance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Laurene Salesse, Cecily Lucas, My Hanh Thi Hoang, Pierre Sauvanet, Alexandra Rezard, Philip Rosenstiel, Christelle Damon-Soubeyrand, Nicolas Barnich, Catherine Godfraind, Guillaume Dalmasso, Hang Thi Thu Nguyen
Summary: Colorectal cancer patients show changes in intestinal flora with an increase in harmful bacteria such as Escherichia coli, which can cause DNA damage. Autophagy is a crucial cell defense mechanism that inhibits tumorigenesis. Targeting autophagy may be a promising strategy to counteract the protumoral effects of bacteria like E. coli producing colibactin.
Article
Microbiology
Richard Bonnet, Racha Beyrouthy, Marisa Haenni, Marie-Helene Nicolas-Chanoine, Guillaume Dalmasso, Jean-Yves Madec
Summary: This study investigated the presence of multidrug-resistant Escherichia coli ST131 in animal reservoirs and identified genetic features associated with different hosts, including virulence factors and metabolic functions. The research revealed a link between host, ST131 population structure, and virulence factor content, indicating that host adaptation plays a key role in the evolution of ST131.
Article
Multidisciplinary Sciences
Bindu Chandrasekharan, Andrew S. Neish
Summary: CLARITY technique is a valuable method for imaging different cell types interacting in the gut environment. Through steps including fixation, embedding, and staining, it allows tracking of cell types such as epithelia, enteroendocrine cells, and neurons.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2021)
Article
Gastroenterology & Hepatology
Bindu Chandrasekharan, Darra Boyer, Joshua A. Owens, Alexandra A. Wolfarth, Bejan J. Saeedi, Tanvi Dhere, Heba Iskandar, Andrew S. Neish
Summary: Selective blocking of NPY receptors using small molecule antagonists can attenuate intestinal inflammation by lowering TNF levels, suggesting a promising therapeutic value for NPY1R inhibition in alleviating inflammation in ulcerative colitis.
INFLAMMATORY BOWEL DISEASES
(2022)
Correction
Gastroenterology & Hepatology
Bindu Chandrasekharan, Darra Boyer, Joshua A. Owens, Alexandra A. Wolfarth, Bejan J. Saeedi, Tanvi Dhere, Heba Iskandar, Andrew S. Neish
INFLAMMATORY BOWEL DISEASES
(2022)
Article
Biochemical Research Methods
Maissa M. M. Gaye, Christina M. M. Ward, Andrew J. J. Piasecki, Vanessa L. L. Stahl, Aikaterini Karagianni, Catherine E. E. Costello, Katya Ravid
Summary: This study found that the JAK2V617F mutation leads to changes in glycosylation, particularly in the beta 1 integrin, in patients with primary myelofibrosis. The glycosylation changes in alpha 2 integrin were more substantial and may also affect activation. The methodology employed in this study has the potential to provide insights into the consequences of integrin activation in MKs at the peptide level.
MOLECULAR & CELLULAR PROTEOMICS
(2022)
Article
Microbiology
Dalmasso Guillaume, Beyrouthy Racha, Brugiroux Sandrine, Ruppe Etienne, Guillouard Laurent, Bonnin Virginie, Saint-Sardos Pierre, Ghozlane Amine, Gaumet Vincent, Barnich Nicolas, Delmas Julien, Bonnet Richard
Summary: Without the use of antibiotics, the plasmid-mediated resistance gene mcr-1 enhances the colonization ability of Escherichia coli in the gut, but impairs its lethal effect. This improvement in gut fitness is associated with a downregulation of intestinal inflammatory markers and the preservation of intestinal microbiota composition.
Meeting Abstract
Gastroenterology & Hepatology
Bindu P. Chandrasekharan, Alexandra Wolfarth, Richard Eboka, Darra Boyer, Andrew S. Neish
Article
Immunology
Racha Beyrouthy, Guillaume Dalmasso, Aurelien Birer, Frederic Robin, Richard Bonnet
EMERGING INFECTIOUS DISEASES
(2020)
