Article
Cell Biology
Feng He, Hang Xiao, Yixin Cai, Ni Zhang
Summary: Unlike angiogenesis in normal tissues, tumor angiogenesis is dysregulated and the HIF1/VEGFA signaling pathway plays an important role. NSD1 transcriptionally regulates HIF1 alpha expression by recruiting STAT3 molecule into the HIF1 alpha promoter, thereby regulating tumor progression and angiogenesis.
CELL BIOLOGY AND TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Marie-Albane Minati, Maxime Libert, Hajar Dahou, Patrick Jacquemin, Mohamad Assi
Summary: Pancreatitis, especially when combined with Kras mutations, is a main driver of pancreatic cancer. Treatment with thiol-containing compound N-acetylcysteine (NAC) can increase pancreatic glutathione levels, reduce oxidative damages, and inhibit the production of inflammatory and tumor-related factors.
Article
Biochemistry & Molecular Biology
Pavel Nedvetsky, Ivo Cornelissen, Thomas Mathivet, Claire Bouleti, Phalla Ou, Pieter Baatsen, Xiaocheng Zhao, Frans Schuit, Fabio Stanchi, Keith E. Mostov, Holger Gerhardt
Summary: Endothelial cAMP-dependent protein kinase A (PKA) plays a crucial role in vascular development and homeostasis. Inhibition of PKA in endothelial cells leads to excessive angiogenesis and severe systemic effects, including edema, hypoalbuminemia, hypoglycemia and premature death. Specifically, PKA inhibition causes disorganization of liver vasculature and abnormal angiogenic response in multiple tissues.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Jia Liu, Zhuojun Liu, Jing Zhang, Xiaofang Chen, Junge Chen, Linlin Sui, Jian Yu
Summary: In this study, the researchers found that Ibrutinib has a stronger cytotoxic effect on endothelial cells compared to Zanubrutinib, while Acalabrutinib has a very weak cytotoxic effect. Ibrutinib was also found to induce endothelial dysfunction through the stimulation of BMP4 expression. The findings suggest the potential use of Ibrutinib in the treatment of angiogenesis-dependent cancers.
Article
Cell Biology
Xiaonian Cao, Wei Wu, Dao Wang, Wei Sun, Senyan Lai
Summary: GSK3 alpha overexpression in non-small cell lung cancer (NSCLC) is associated with shorter survival time in patients. GSK3 alpha overexpression promotes proliferation, migration, invasion, and clone formation ability of NSCLC cells, while its inhibition has the opposite effect. GSK3 alpha regulates the HIF1/VEGFA signaling pathway independently through the PHDs-pVHL pathway, thereby influencing tumor angiogenesis in NSCLC.
CELL COMMUNICATION AND SIGNALING
(2022)
Review
Oncology
Valentina Diehl, Lisa Sophie Huber, Jonel Trebicka, Malgorzata Wygrecka, Renato V. Iozzo, Liliana Schaefer
Summary: Decorin and biglycan play critical roles in tumor biology by influencing key processes that affect tumor growth and progression. Despite their structural homology, these proteoglycans interact with different cell surface receptors, modulating distinct signaling pathways that ultimately impact cancer development.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Lu Zhang, Hongxin Cao, Guanghui Gu, Dehui Hou, Yunhao You, Xiang Li, Yunzhen Chen, Guangjun Jiao
Summary: miR-199a-5p can be transported from osteosarcoma cells to HUVECs through exosomes, subsequently targeting VEGFA and inhibiting the growth and angiogenesis of osteosarcoma. Therefore, miR-199a-5p may act as a biomarker in the diagnosis and treatment of osteosarcoma.
FRONTIERS IN ONCOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Jurjan Aman, Coert Margadant
Summary: The endothelium is a dynamic layer lining blood vessels, regulating blood vessel formation and barrier function. Dysregulation of endothelial barrier properties can lead to severe clinical conditions. Recent research has highlighted the important role of integrin-mediated cell-matrix adhesion and signaling in endothelial barrier regulation. Understanding these mechanisms may provide novel treatment targets for diseases characterized by vascular leak.
CIRCULATION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Rushendhiran Kesavan, Timo Froemel, Sven Zukunft, Bernhard Bruene, Andreas Weigert, Ilka Wittig, Ruediger Popp, Ingrid Fleming
Summary: Studies suggest that the absence of soluble epoxide hydrolase (sEH) accelerates primary tumor growth and increases tumor macrophage count and angiogenesis in animals. However, there is no impact of sEH inhibition on the formation of metastases in the lymph node or lung.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Ameen A. Salahudeen, Jose A. Seoane, Kanako Yuki, Amanda T. Mah, Amber R. Smith, Kevin Kolahi, M. de la O. Sean, Daniel J. Hart, Jie Ding, Zhicheng Ma, Sammy A. Barkal, Navika D. Shukla, Chuck H. Zhang, Michael A. Cantrell, Arpit Batish, Tatsuya Usui, David E. Root, William C. Hahn, Christina Curtis, Calvin J. Kuo
Summary: This study utilized organoid modeling to evaluate candidate oncogenic loci and functionally assess them during early tumorigenesis. The study identified DYRK2 and FGF3 as oncogenes in specific cancer types.
Review
Toxicology
Hardeep Singh Tuli, Jagjit Kaur, Kanupriya Vashishth, Katrin Sak, Ujjawal Sharma, Renuka Choudhary, Tapan Behl, Tejveer Singh, Sheetu Sharma, Adesh K. Saini, Kuldeep Dhama, Mehmet Varol, Gautam Sethi
Summary: ROS plays important roles in living organisms, with moderate levels affecting disease development and excessive levels leading to cell death. Current research is focused on using chemotherapy drugs and herbal agents to induce cancer cell death, while maintaining ROS homeostasis is crucial for cell development and survival.
ARCHIVES OF TOXICOLOGY
(2023)
Article
Oncology
Behnam Rashidieh, Amanda Louise Bain, Simon Manuel Tria, Sowmya Sharma, Cameron Allan Stewart, Jacinta Ley Simmons, Pirjo M. Apaja, Pascal H. G. Duijf, John Finnie, Kum Kum Khanna
Summary: Through the Cryab overexpression knock-in mouse model, it was found that CRYAB overexpression led to the formation of various lethal tumors, correlated with upregulation of epithelial-to-mesenchymal transition markers, angiogenesis, and some oncogenic proteins. Further experiments showed that CRYAB overexpression promoted cell survival by upregulating Akt signaling and downregulating JNK-mediated pro-apoptotic pathway, inhibiting apoptosis.
EXPERIMENTAL HEMATOLOGY & ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ping Mao, Tuo Wang, Chang-Wang Du, Xiao Yu, Mao-De Wang
Summary: The overexpression of CXCL5 is associated with cell proliferation, angiogenesis, and poor prognosis in glioblastoma. Inhibition of CXCL5 effectively suppresses these processes and improves survival rates in animal models. Targeting CXCL5 may be a potential therapeutic approach for glioblastoma.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Engineering, Biomedical
Wenxi Li, Jie Yan, Hao Tian, Bei Li, Guohao Wang, Wei Sang, Zhan Zhang, Xuanjun Zhang, Yunlu Dai
Summary: The interaction between PD-1 and PD-L1 in malignant melanoma cells promotes tumorigenesis, angiogenesis, and radio-resistance through mTOR hyperactivation. Blocking PD-L1 and mTOR signaling concurrently, along with radiotherapy, can alleviate tumor burden. A three-pronged platinum@polymer-catechol nanobraker, delivering mTOR inhibitor TAK228 and anti-PD-L1 antibody, effectively inhibits melanoma-PD-1-driven aggression and enhances melanoma eradication, while also amplifying the efficacy of radiotherapy.
BIOACTIVE MATERIALS
(2023)
Article
Medicine, Research & Experimental
Cosmin Ene, Ilinca Nicolae, Corina Daniela Ene
Summary: This study aimed to investigate the altered angiogenetic mechanisms in prostate tumor patients under hypoxic conditions and its correlation with common clinicopathologic variables. The results showed increased inflammation levels, upregulation of HIF1 & alpha;, and angiogenesis abnormalities in both prostate cancer and benign prostatic hyperplasia patients. These findings are of great importance for early diagnosis of prostate pathology and individualized therapeutic approaches.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2023)
Article
Food Science & Technology
Rachel E. Kopec, Jonathan Schick, Kathleen L. Tober, Ken M. Riedl, David M. Francis, Gregory S. Young, Steven J. Schwartz, Tatiana M. Oberyszyn
MOLECULAR NUTRITION & FOOD RESEARCH
(2015)
Article
Biochemistry & Molecular Biology
Katherine L. Gressel, F. Jason Duncan, Tatiana M. Oberyszyn, Krista M. La Perle, Helen B. Everts
PHOTOCHEMISTRY AND PHOTOBIOLOGY
(2015)
Article
Food Science & Technology
Matthew D. Teegarden, Amanda R. Campbell, Jessica L. Cooperstone, Kathleen L. Tober, Steven J. Schwartz, Tatiana M. Oberyszyn
MOLECULAR NUTRITION & FOOD RESEARCH
(2017)
Article
Biochemistry & Molecular Biology
S. Beesetti, J. Mavuluri, R. P. Surabhi, T. M. Oberyszyn, K. Tober, R. S. Pitani, L. D. Joseph, G. Venkatraman, S. K. Rayala
Article
Oncology
Rebecca C. Hennessey, Andrea M. Holderbaum, Anamaria Bonilla, Conor Delaney, James E. Gillahan, Kathleen L. Tober, Tatiana M. Oberyszyn, Jonathan H. Zippin, Christin E. Burd
PIGMENT CELL & MELANOMA RESEARCH
(2017)
Article
Dermatology
Kelly E. Johnson, Brian C. Wulff, Tatiana M. Oberyszyn, Traci A. Wilgus
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2013)
Article
Oncology
Erin M. Burns, Kathleen L. Tober, Judith A. Riggenbach, Jonathan S. Schick, Keith N. Lamping, Donna F. Kusewitt, Gregory S. Young, Tatiana M. Oberyszyn
Article
Dermatology
Nicholas J. Sullivan, Kathleen L. Tober, Erin M. Burns, Jonathan S. Schick, Judith A. Riggenbach, Thomas A. Mace, Matthew A. Bill, Gregory S. Young, Tatiana M. Oberyszyn, Gregory B. Lesinski
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2012)
Letter
Dermatology
Carlos J. Perez, Joyce E. Rundhaug, David G. Johnson, Tatiana M. Oberyszyn, Kathleen L. Tober, Donna F. Kusewitt
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2014)
Article
Oncology
Priyadharsini Nagarajan, Kathleen L. Tober, Judith A. Riggenbach, Donna F. Kusewitt, Amy M. Lehman, Thais Sielecki, James Pruitt, Abhay R. Satoskar, Tatiana M. Oberyszyn
MOLECULAR CANCER RESEARCH
(2014)
Article
Food Science & Technology
Gregory V. Bricker, Kenneth M. Riedl, Robin A. Ralston, Kathleen L. Tober, Tatiana M. Oberyszyn, Steven J. Schwartz
MOLECULAR NUTRITION & FOOD RESEARCH
(2014)
Article
Multidisciplinary Sciences
Firdaus S. Dhabhar, Alison N. Saul, Tyson H. Holmes, Christine Daugherty, Eric Neri, Jean M. Tillie, Donna Kusewitt, Tatiana M. Oberyszyn
Article
Multidisciplinary Sciences
Erin M. Burns, Kathleen L. Tober, Judith A. Riggenbach, Donna F. Kusewitt, Gregory S. Young, Tatiana M. Oberyszyn
Article
Multidisciplinary Sciences
Natasha T. Hill, Gabriel H. Gracia-Maldonado, Mary K. Leonard, Amanda R. Harper, Kathleen L. Tober, Tatiana M. Oberyszyn, Madhavi P. Kadakia
Article
Multidisciplinary Sciences
Jessica L. Cooperstone, Kathleen L. Tober, Ken M. Riedl, Matthew D. Teegarden, Morgan J. Cichon, David M. Francis, Steven J. Schwartz, Tatiana M. Oberyszyn
SCIENTIFIC REPORTS
(2017)