Article
Immunology
Alba Llibre, Nikaia Smith, Vincent Rouilly, Munyaradzi Musvosvi, Elisa Nemes, Celine Posseme, Simbarashe Mabwe, Bruno Charbit, Stanley Kimbung Mbandi, Elizabeth Filander, Hadn Africa, Violaine Saint-Andre, Vincent Bondet, Pierre Bost, Humphrey Mulenga, Nicole Bilek, Matthew L. Albert, Thomas J. Scriba, Darragh Duffy
Summary: This study reveals the differences in immune responses at the transcriptomic, proteomic, and metabolomic levels between tuberculosis and latent tuberculosis infection. Dysregulated IL-1 responses were observed in tuberculosis patients after BCG stimulation, while differences in IL-1 alpha/IL-1 beta secretion were associated with downstream differences in granzyme mediated cleavage in latent tuberculosis infection/tuberculosis after BCG stimulation. Furthermore, IL-1 beta driven signalling was significantly perturbed in tuberculosis disease but was completely restored after successful treatment.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Plant Sciences
Xiaohui Su, Bei Yuan, Xueying Tao, Wanyi Guo, Xia Mao, Anguo Wu, Qian Wang, Chunfang Liu, Yanqiong Zhang, Xiangying Kong, Lan Han, Na Lin
Summary: In this study, the Chinese patent medicine Yuxuebi was found to have anti-angiogenic effects in collagen-induced arthritis and VEGF-induced HUVECs. Yuxuebi reduced disease severity and ameliorated pathological features in arthritis models, suppressed angiogenesis, and inhibited the LOX/Ras/Raf-1 signaling pathway. These findings suggest that Yuxuebi may be a potential therapeutic option for rheumatoid arthritis.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Food Science & Technology
Zhuangzhuang Liu, Ximeng Li, Wenjing Li, Min Cai, Jingjing Yan, Chenchen Zang, Runlan Cai, Yuan Gao, Yun Qi
Summary: Osmanthus fragrans flower, a common edible plant in China, has been used as a food ingredient and traditional Chinese medicine for centuries. Research has shown that its extract has anti-inflammatory effects by suppressing the production of pro-inflammatory mediators and inhibiting the activation of NF-kappa B and AP-1 signaling pathways.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Review
Biochemistry & Molecular Biology
Beatriz Burger, Roberta Nicolli Sagiorato, Isabella Cavenaghi, Hosana Gomes Rodrigues
Summary: Psoriasis is an immune-mediated skin disorder, and alterations in sphingolipids synthesis have been observed in psoriatic skin. By analyzing gene expression in psoriatic skin, several genes related to lipid metabolism, specifically sphingolipids, were found to be up-regulated in lesioned skin. These genes could potentially serve as prognostic biomarkers and therapeutic targets for psoriasis treatment.
Article
Medicine, Research & Experimental
Xiaoyu Zhang, Yuan Kang, Ximeng Li, Yunfeng Huang, Ruijuan Qi, Yixin Han, Runlan Cai, Yuan Gao, Yun Qi
Summary: Potentilla discolor Bunge (PD) is a traditional Chinese medicine with strong anti-inflammatory effects by suppressing the expressions of iNOS, TNF-α, and MCP-1, as well as inhibiting the activation of NF-kappa B and AP-1. The ethanol extract of the whole herbs of PD (EPD) shows promising therapeutic potential for inflammatory diseases, especially intestinal inflammation, through its ability to modulate inflammatory mediators and signaling pathways.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Immunology
Ioannis Kienes, Ella L. Johnston, Natalie J. Bitto, Maria Kaparakis-Liaskos, Thomas A. Kufer
Summary: This article summarizes the subversion strategies used by bacterial pathogens to evade host immune detection, focusing on the well-studied NLRs NOD1/2, NLRP3, and NLRC4. The authors discuss how bacterial pathogens activate these NLRs to promote inflammation and disease, as well as mechanisms used by bacteria to attenuate NLR activation and interfere with host immunity. They also highlight the role of NLRs in facilitating immunotolerance and persistence of bacteria in the host, and the therapeutic potential of harnessing bacterial immune subversion strategies for chronic inflammatory conditions.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Jessica Filtjens, Anais Roger, Linda Quatrini, Elisabeth Wieduwild, Jordi Gouilly, Guillaume Hoeffel, Rafaelle Rossignol, Clara Daher, Guilhaume Debroas, Sandrine Henri, Claerwen M. Jones, Bernard Malissen, Laura K. Mackay, Aziz Moqrich, Francis R. Carbone, Sophie Ugolini
Summary: The study demonstrates that Nav(1.8)(+) sensory neurons play a crucial role in regulating CD8 T cell immune responses against HSV-1 infection, affecting skin damage severity and cytokine production. Sensory neurons are also involved in controlling neutrophil infiltration and dendritic cell responses, highlighting their potential as a therapeutic target.
NATURE COMMUNICATIONS
(2021)
Review
Virology
Eman Teer, Nyasha C. Mukonowenzou, M. Faadiel Essop
Summary: This article explores the relationship between immune metabolism and HIV pathogenesis, revealing that metabolic reprogramming plays a crucial role in HIV-1 pathogenesis. The shift from quiescent immune cells to activation leads to metabolic perturbations that drive immune cell dysfunction and altered phenotype.
Review
Neurosciences
Fiona Weiss, Adahir Labrador-Garrido, Nicolas Dzamko, Glenda Halliday
Summary: Immune changes occur in neurodegenerative conditions, with significant differences between diseases. In Parkinson's disease, there is increased inflammation and elevated pro-inflammatory cytokines in the brain. Astrocytes in Parkinson's disease exhibit a dysfunctional phenotype, contributing to disease progression. Peripheral immune cells, such as T cells and monocytes, also infiltrate the Parkinson's disease brain.
NEUROBIOLOGY OF DISEASE
(2022)
Review
Cell Biology
Lili Qu, Baihai Jiao
Summary: Kidney disease affects approximately 10% of the global population and encompasses a range of disorders with different underlying causes. These disorders are characterized by immune system dysregulation and metabolic disturbances, which contribute to kidney inflammation and progressive fibrosis. Recent studies have highlighted the importance of the interplay between immune and metabolic pathways in kidney diseases, revealing potential therapeutic targets for intervention.
Review
Oncology
Sharmistha Dey, Abhay Kumar Singh, Abhinay Kumar Singh, Kartik Rawat, Joyita Banerjee, Vertica Agnihotri, Deepak Upadhaya
Summary: The rapid growth of oral cancer is a significant concern, especially in developing countries. Early detection and development of novel therapies can improve patient survival. This review explores the key pathways in oral cancer and analyzes the association between protein expression level, genetic mutation, and therapeutic intervention.
Article
Cell Biology
Jiao Liu, Shan Zhu, Ling Zeng, Jingbo Li, Daniel J. Klionsky, Guido Kroemer, Jianxin Jiang, Daolin Tang, Rui Kang
Summary: This study reveals that the proteoglycan decorin (DCN) serves as an alarm signal during ferroptosis, triggering immune responses through the DCN-AGER axis to induce pro-inflammatory cytokines. Inhibition of the DCN-AGER axis protects against ferroptotic death-related acute pancreatitis and limits the tumor-protective immune response induced by ferroptotic cancer cells. Thus, DCN is shown to be a crucial mediator of the inflammatory and immune consequences of ferroptosis.
Review
Genetics & Heredity
Aoife A. Nolan, Nourhan K. Aboud, Walter Kolch, David Matallanas
Summary: Oncogenic RAS mutations are key drivers of human cancers, making RAS inhibition a crucial goal in oncology. Efforts to block effector pathways like RAF-MEK-ERK have been largely disappointing, leading researchers to investigate RAF-dependent pathways independent of catalytic activity as potential targets for blocking oncogenic RAS signaling. The roles of RAF kinase-independent functions in apoptosis, cell cycle progression, and cell migration have been well documented.
Review
Immunology
Yohei Maki, Satoshi Kashiwagi, Yoshifumi Kimizuka
Summary: Laser vaccine adjuvants, utilizing the physical energy of light, have emerged as a promising alternative to conventional adjuvants. They have the potential to enhance vaccine efficacy, salvage abandoned candidate vaccines, and aid in global vaccine distribution.
Review
Neurosciences
Jialing Liu, Yoshimichi Sato, Jaime Falcone-Juengert, Kota Kurisu, Jian Shi, Midori A. Yenari
Summary: Recent studies on stroke have found significant differences between sexes in terms of risk and outcome. Although earlier research has focused on differences in sex hormones, the reasons for these differences are more complex. This review examines differences in sex-related immune responses, highlighting disparities in immune cell composition and function. While females are more susceptible to immune-related diseases, experimental findings suggest they have better outcomes from stroke with reduced pro-inflammatory responses.
NEUROBIOLOGY OF DISEASE
(2022)
Article
Cell Biology
Laura Mercurio, Daniela Lulli, Francesca Mascia, Elena Dellambra, Claudia Scarponi, Martina Morelli, Carola Valente, Maria Luigia Carbone, Sabatino Pallotta, Giampiero Girolomoni, Cristina Albanesi, Saveria Pastore, Stefania Madonna
Article
Multidisciplinary Sciences
Laura Mercurio, Cristina M. Failla, Lorena Capriotti, Claudia Scarponi, Francesco Facchiano, Martina Morelli, Stefania Rossi, Gianluca Pagnanelli, Cristina Albanesi, Andrea Cavani, Stefania Madonna
Review
Immunology
Bapi Pahar, Stefania Madonna, Arpita Das, Cristina Albanesi, Giampiero Girolomoni
Article
Biotechnology & Applied Microbiology
Martina Morelli, Marco Galluzzo, Stefania Madonna, Claudia Scarponi, Giovanni Luca Scaglione, Tiziana Galluccio, Marco Andreani, Sabatino Pallotta, Giampiero Girolomoni, Luca Bianchi, Marina Talamonti, Cristina Albanesi
Summary: This pharmacogenomic study examined the impact of genetic variants of psoriasis-risk loci on the clinical response to secukinumab, identifying specific SNPs associated with excellent response and defining patterns of SNPs related to different responses in HLA-Cw6(+) and HLA-Cw6(-) patients. Assessment of HLA-Cw6 and other allelic variants may help to identify patients who benefit most from anti-IL-17 therapy.
EXPERT OPINION ON BIOLOGICAL THERAPY
(2021)
Review
Medicine, General & Internal
Laura Mercurio, Cristina Albanesi, Stefania Madonna
Summary: PI3K represents a family of kinases that control multiple biological processes in mammalian cells and is associated with various skin pathologies. The dysregulation of PI3K/AKT/mTOR pathway contributes to uncontrolled cell proliferation and resistance to apoptosis in skin cancers, while also leading to enhanced proliferation, defective differentiation, and anti-apoptosis in psoriasis. The role of PI3K/AKT/mTOR in atopic dermatitis is less characterized, with recent evidence highlighting its function in epidermal barrier formation and stratification.
FRONTIERS IN MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Laura Mercurio, Martina Morelli, Claudia Scarponi, Giovanni Luca Scaglione, Sabatino Pallotta, Daniele Avitabile, Cristina Albanesi, Stefania Madonna
Summary: The study reveals that NAMPT-mediated NAD salvage pathway plays a role in psoriasis by amplifying immune responses in the skin. NAMPT induces hyper-proliferation in keratinocytes and impairs their terminal differentiation, contributing to inflammatory responses associated with psoriasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Laura Mercurio, Martina Morelli, Claudia Scarponi, Giovanni Luca Scaglione, Sabatino Pallotta, Cristina Albanesi, Stefania Madonna
Summary: The study found that PI3K delta is overexpressed in psoriatic plaques, promoting keratinocyte hyperproliferation and impaired terminal differentiation, as well as inducing epithelial inflammation. Inhibiting PI3K delta with seletalisib attenuates the severity of psoriasiform phenotype and restores physiological proliferation and differentiation programs in epidermal keratinocytes.
Article
Biochemistry & Molecular Biology
Luca Fania, Gaia Moretta, Flaminia Antonelli, Enrico Scala, Damiano Abeni, Cristina Albanesi, Stefania Madonna
Summary: Atopic dermatitis (AD) is a common chronic inflammatory skin disease characterized by intense itching and recurrent eczematous lesions. The pathogenesis of AD involves genetic background, skin barrier dysfunction, immune responses, and itch. Skin dehydration caused by filaggrin mutations is a key feature of AD. Cytokines play an important role in the pathogenesis of AD, and the cytokine patterns vary in patients with different clinical phenotypes. Understanding the correlation between cytokine patterns and clinical forms of AD is crucial for personalized therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Fernanda Scopelliti, Laura Mercurio, Caterina Cattani, Valentina Dimartino, Cristina Albanesi, Gianfranco Costanzo, Concetta Mirisola, Stefania Madonna, Andrea Cavani
Summary: PI3K p110 delta plays a crucial role in regulating the functions of human dendritic cells, and selective inhibition with seletalisib can reduce the maturation and antigen-presenting functions of DCs, leading to a decreased immune response and increased cell migration.
JOURNAL OF LEUKOCYTE BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Angela Cappello, Mara Mancini, Stefania Madonna, Serena Rinaldo, Alessio Paone, Claudia Scarponi, Antonio Belardo, Lello Zolla, Alessandro Zuccotti, Emanuele Panatta, Sabatino Pallotta, Margherita Annicchiarico-Petruzzelli, Cristina Albanesi, Francesca Cutruzzola, Lu Wang, Wei Jia, Gerry Melino, Eleonora Candi
Summary: This study reveals the importance of SHMT2 activity and the availability of serine/glycine as a metabolic hub controlling both keratinocyte proliferation and inflammatory cell expansion in psoriasis, providing potential new approaches for the treatment of skin diseases.
Article
Immunology
Martina Morelli, Marco Galluzzo, Claudia Scarponi, Stefania Madonna, Giovanni Luca Scaglione, Giampiero Girolomoni, Marina Talamonti, Luca Bianchi, Cristina Albanesi
Summary: Ustekinumab is an effective biologic therapy for psoriasis, but patient responses vary. This study identified 12 SNPs associated with excellent response to ustekinumab and found that HLA-C gene variations could help determine which patients would benefit from anti-IL-12/IL-23 therapy.
Article
Pathology
Luca Fania, Martina Morelli, Claudia Scarponi, Laura Mercurio, Fernanda Scopelliti, Caterina Cattani, Giovanni Luca Scaglione, Tiziano Tonanzi, Maria Antonietta Pilla, Gianluca Pagnanelli, Cinzia Mazzanti, Giampiero Girolomoni, Andrea Cavani, Stefania Madonna, Cristina Albanesi
JOURNAL OF PATHOLOGY CLINICAL RESEARCH
(2020)