Article
Pharmacology & Pharmacy
Yoshihiro Oaku, Akinari Abe, Yohei Sasano, Fuka Sasaki, Chika Kubota, Naoki Yamamoto, Tohru Nagahama, Noriaki Nagai
Summary: In this study, we found that MXD-NPs prepared using the bead mill method demonstrated better hair follicle delivery and hair growth promotion compared to commercially available CA-MXD solution. MXD-NPs enabled the accumulation of MXD in the upper hair follicles more efficiently and activated HFSC, leading to hair growth.
Article
Agriculture, Dairy & Animal Science
Chunhui Duan, Lechao Zhang, Kun Gao, Yunxia Guo, Yueqin Liu, Yingjie Zhang
Summary: This study investigated the differences in cashmere traits, yield, hair follicle characteristics, and fiber-style-related genes between Yanshan cashmere goats with non-crimped and crimped fleece. The results revealed that goats with crimped fleece produced a higher yield of cashmere with finer diameter fibers compared to goats with non-crimped fleece. Mutations in the KRT1 and KRT6A genes may be associated with these differences in fiber properties.
Article
Multidisciplinary Sciences
Koya Suzuki, Kosuke Yamaga, Reitaro Tokumasu, Tatsuya Katsuno, Hiroo Tanaka, Shuhei Chiba, Takeshi Yagi, Ichiro Katayama, Atsushi Tamura, Hiroyuki Murota, Sachiko Tsukita
Summary: Hair retention in infant mice is regulated by Claudin (CLDN)-1 and CLDN3, which maintain the appropriate layered architecture of hair follicles. Deficiencies in these proteins can lead to hair loss.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2023)
Article
Dermatology
Carlos J. Perez, Lars Mecklenburg, Almudena Fernandez, Marta Cantero, Tiago Antonio de Souza, Kevin Lin, Sharon Y. R. Dent, Lluis Montoliu, Alexander Awgulewitsch, Fernando Benavides
Summary: Loss of function mutations in the HOXC13 gene have been linked to Ectodermal Dysplasia-9, Hair/Nail Type (ECTD9). The spontaneous mouse mutation Naked (N) is identified as a terminal truncation in the Hoxc13 gene. The N/N mice exhibit generalized alopecia with abnormal nails, while N/+ mice show partial alopecia and normal lifespan, indicating a potentially dominant-negative mutation.
EXPERIMENTAL DERMATOLOGY
(2022)
Article
Pathology
Kyoko Kobayashi, Susumu Iwaide, Hiroki Sakai, Fuyuki Kametani, Tomoaki Murakami
Summary: This study identified the presence of cutaneous keratinic amyloid deposition in dogs and identified CK5 as an amyloid precursor protein. There was a significantly higher incidence of amyloid deposition in Shiba dogs, and CK5 amino acid polymorphisms were identified in these dogs.
VETERINARY PATHOLOGY
(2023)
Article
Engineering, Biomedical
Mafalda Correia, Joana Lopes, Daniela Lopes, Ana Melero, Pooyan Makvandi, Francisco Veiga, Jorge F. J. Coelho, Ana C. Fonseca, Ana Claudia Paiva-Santos
Summary: This review discusses nanotechnology-based strategies for hair follicle (HF) regeneration, including controlled drug release and HF-specific targeting. In addition to traditional hair repair methods, wound-induced hair neogenesis (WIHN) has gained attention as a research focus. HF regeneration involves various modalities and technologies, including modulation of the hair cycle, stimulation of progenitor cells and signaling pathways, tissue engineering, WIHN, and gene therapy.
Article
Biochemistry & Molecular Biology
Min-Kyung Nam, Hyun-Ah Shin, HeeJae Yun, Seung-Ah Yoo, Hyangshuk Rhim
Summary: The inactivation of HtrA2 leads to changes in skin color and delayed hair growth cycle in mice, caused by the retardation of adipocyte growth.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Review
Cell Biology
Sangbum Park
Summary: Hair follicles undergo continuous growth and regression cycles driven by the regulation of stem cells and niche components. Complex morphogenesis is required to build the structure of hair follicles during embryonic development. Understanding the formation and maintenance of hair follicles, as well as the mechanisms for hair follicle generation and skin regeneration, is crucial.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Medicine, General & Internal
Wei Tu, Yu-Wei Cao, Mang Sun, Qian Liu, Heng-Guang Zhao
Summary: This review examines the function of mTOR signaling in hair follicles and hair diseases, and discusses the underlying molecular mechanisms that mTOR signaling regulates.
FRONTIERS IN MEDICINE
(2023)
Article
Multidisciplinary Sciences
Carla M. Abreu, Mariana T. Cerqueira, Rogerio P. Pirraco, Luca Gasperini, Rui L. Reis, Alexandra P. Marques
Summary: The conditioned medium from interfollicular keratinocytes (KCs-CM) has been shown to improve the hair inductive ability of DP cells, with significant effects on DP cell growth and restoration of activity. Additionally, DP cells cultured with KCs-CM in spheroids demonstrated superior activity and supported the formation of hair follicle- and sebaceous gland-like structures in mice when co-grafted with human keratinocytes.
JOURNAL OF ADVANCED RESEARCH
(2021)
Review
Cell Biology
Min Yang, Tingting Weng, Wei Zhang, Manjia Zhang, Xiaojie He, Chunmao Han, Xingang Wang
Summary: Alopecia is a commonly seen issue affecting various age groups, with hair follicle regeneration considered as a strategy to address this problem. Non-coding RNAs, particularly microRNAs and long ncRNAs, play crucial regulatory roles in hair follicle development and regeneration.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemical Research Methods
Allen W. Lynch, Christina Theodoris, Henry Long, Myles Brown, X. Shirley Liu, Clifford A. Meyer
Summary: MIRA is a comprehensive methodology that compares gene expression and chromatin accessibility in single cells to infer regulatory mechanisms driving cell fate transitions. It models cell states and regulatory potential of gene loci to represent cell states in an efficient and interpretable latent space, and reveals the variable influence of local accessibility on transcription at different gene loci.
Review
Biochemistry & Molecular Biology
Matej Znidaric, Zan Michel Zurga, Uros Maver
Summary: The field of hair research has advanced significantly in recent decades, particularly in the development of in vitro hair follicle models. The focus has been on manipulating cellular and molecular features to grow functional in vitro hair follicles. Challenges still remain in fully understanding follicle behavior and successfully creating different types of hair through in vitro methods.
Article
Cell & Tissue Engineering
Yuyang Gan, Hailin Wang, Lijuan Du, Zhexiang Fan, Pingping Sun, Kaitao Li, Qian Qu, Jin Wang, Ruosi Chen, Zhiqi Hu, Yong Miao
Summary: A large number of pelage HF-MSCs can be quickly and conveniently isolated from adult mice using a two-step Ficoll density gradient sedimentation method. These cells possess similar characteristics and functions as whisker HF-MSCs and can promote hair growth by secreting exosomes.
STEM CELL RESEARCH & THERAPY
(2022)
Review
Cell Biology
Sunil S. Adav, Kee Woei Ng
Summary: Aging is a complex process that affects physiological functions, including hair graying, thinning, and loss. These changes in hair can have a significant impact on an individual's self-esteem and mental health. Omics technologies have helped lead to the discovery of hair aging biomarkers and potential therapies.
AGEING RESEARCH REVIEWS
(2023)
Article
Biochemistry & Molecular Biology
Kanako Shiratori, Kaori Kanemaru, Takahiro Ogura, Aya Nakajima, Yuko Sugizaki, Takatsugu Fukuyama, Yoichiro Iwakura, Yoshikazu Nakamura, Kiyoko Fukami
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2019)
Article
Dermatology
Takatsugu Fukuyama, Yoshikazu Nakamura, Kaori Kanemaru, Chiho Toyoda, Hyun-Jun Jang, Pann-Ghill Suh, Kiyoko Fukami
EXPERIMENTAL DERMATOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Atsuko Yoneda, Kaori Kanemaru, Ai Matsubara, Erika Takai, Makoto Shimozawa, Reiko Satow, Hideki Yamaguchi, Yoshikazu Nakamura, Kiyoko Fukami
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2020)
Article
Multidisciplinary Sciences
Yoshikazu Nakamura, Kaori Kanemaru, Madoka Shoji, Kengo Totoki, Karen Nakamura, Hidemasa Nakaminami, Keisuke Nakase, Norihisa Noguchi, Kiyoko Fukami
SCIENTIFIC REPORTS
(2020)
Article
Oncology
Tatsuya Kobayashi, Makoto Miyazaki, Nobuyoshi Sasaki, Shun Yamamuro, Eita Uchida, Daisuke Kawauchi, Masamichi Takahashi, Yohei Otsuka, Kosuke Kumagai, Satoru Takeuchi, Terushige Toyooka, Naoki Otani, Kojiro Wada, Yoshitaka Narita, Hideki Yamaguchi, Yoshihiro Muragaki, Takakazu Kawamata, Kentaro Mori, Koichi Ichimura, Arata Tomiyama
Article
Neurosciences
Sung Jin Park, Kirk D. Haan, Yoshikazu Nakamura, Kiyoko Fukami, Thomas E. Fisher
Summary: The study revealed that the PLC delta 1 isoform plays a crucial role in the activation of Delta N-TRPV1 channels and osmosensory transduction in MNCs, with its absence leading to impaired MNC function. This research advances our understanding of the molecular mechanisms of osmoregulation in mammals.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Oncology
Yuko Nagamura, Makoto Miyazaki, Yoshiko Nagano, Masako Yuki, Kiyoko Fukami, Kazuyoshi Yanagihara, Kazuki Sasaki, Ryuichi Sakai, Hideki Yamaguchi
Summary: This study identified PLEKHA5 as a protein downstream of Met that is tyrosine-phosphorylated in DGC cells with Met gene amplification. Knockdown of PLEKHA5 selectively suppressed the growth of these cells by inducing apoptosis and abrogated malignant phenotypes, suggesting its essential role in Met-addicted DGC progression. Mechanistically, PLEKHA5 dysregulation of glycolytic metabolism activates the JNK pathway to promote apoptosis.
Article
Oncology
Yuko Nagamura, Makoto Miyazaki, Yoshiko Nagano, Arata Tomiyama, Rieko Ohki, Kazuyoshi Yanagihara, Ryuichi Sakai, Hideki Yamaguchi
Summary: Diffuse-type gastric carcinoma (DGC) is characterized by aggressive progression associated with rapid infiltrative growth, massive fibrosis, and peritoneal dissemination. In this study, SHP2 was identified as a critical regulator downstream of the amplified Met and FGFR2 receptor tyrosine kinases (RTKs) in DGC cell lines. Targeting SHP2 selectively suppressed the growth and malignant phenotypes of RTK-addicted DGC, highlighting its potential as a therapeutic target for DGC treatment.
Article
Oncology
Shingo Miyamoto, Yoshiko Nagano, Makoto Miyazaki, Yuko Nagamura, Kazuki Sasaki, Takeshi Kawamura, Kazuyoshi Yanagihara, Toshio Imai, Rieko Ohki, Masakazu Yashiro, Masato Tanaka, Ryuichi Sakai, Hideki Yamaguchi
Summary: The study revealed that integrin alpha 5 plays a crucial role in mediating the heterotypic cancer cell-fibroblast interaction during peritoneal dissemination of DGC, suggesting it may be a potential therapeutic target.
Article
Multidisciplinary Sciences
Kazuya Tsujita, Reiko Satow, Shinobu Asada, Yoshikazu Nakamura, Luis Arnes, Keisuke Sako, Yasuyuki Fujita, Kiyoko Fukami, Toshiki Itoh
Summary: Changes in cell mechanics contribute to cancer cell dissemination. High plasma membrane (PM) tension inhibits cancer dissemination by counteracting mechanosensitive BAR family protein assembly, while restoration of PM tension phenotypically convert malignant cells into a non-motile epithelial cell state.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Takuya Shirakihara, Hideki Yamaguchi, Tadashi Kondo, Masakazu Yashiro, Ryuichi Sakai
Summary: The study reveals that in diffuse-type gastric cancer cells, transferrin receptor 1 (TfR1) binds and phosphorylates with fibroblast growth factor receptor 2 (FGFR2), promoting cell proliferation and tumorigenicity. This suggests that controlling TfR1 function could serve as a therapeutic target in diffuse-type gastric cancer with activated FGFR2.
Article
Multidisciplinary Sciences
Kaori Kanemaru, Makoto Shimozawa, Manabu Kitamata, Rikuto Furuishi, Hinako Kayano, Yui Sukawa, Yuuki Chiba, Takatsugu Fukuyama, Junya Hasegawa, Hiroki Nakanishi, Takuma Kishimoto, Kazuya Tsujita, Kazuma Tanaka, Toshiki Itoh, Junko Sasaki, Takehiko Sasaki, Kiyoko Fukami, Yoshikazu Nakamura
Summary: This study reveals the critical role of phospholipid phosphatidylinositol (4,5)-bisphosphate in maintaining the characteristics of epithelial cells.
NATURE COMMUNICATIONS
(2022)
Review
Oncology
Hideki Yamaguchi, Yuko Nagamura, Makoto Miyazaki
Summary: Gastric cancer is a leading cause of cancer-related death globally, with diffuse-type gastric carcinoma exhibiting aggressive progression and high recurrence rate. Gene amplification and aberrant activation of receptor tyrosine kinase signaling play a crucial role in the development and peritoneal metastasis of diffuse-type gastric carcinoma.
Meeting Abstract
Oncology
Makoto Miyazaki, Shingo Miyamoto, Kazuyoshi Yanagihara, Kiyoko Fukami, Hideki Yamaguchi