Review
Ophthalmology
Jorge L. Alio, Andrea Montesel, Fouad El Sayyad, Rafael Ignacio Barraquer, Francisco Arnalich-Montiel, Jorge Luis Alio Del Barrio
Summary: Corneal graft surgery is a successful form of tissue transplantation, but still faces relevant risk of failure due to factors like immunological rejection, late endothelial failure, and ocular surface disorders. Different surgical techniques have varying rates of failure, with penetrating keratoplasty having higher failure rates than lamellar keratoplasty.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2021)
Review
Ophthalmology
Clarissa E. H. Fang, Rashmi G. Mathew, Peng T. Khaw, Christin Henein
Summary: This study comprehensively analyzed the effects of various common glaucoma surgeries on corneal endothelial cell density (ECD). The results showed that surgeries involving long-term implants led to greater ECD loss compared to surgeries without implants. These findings are important for assessing ECD loss and corneal decompensation after glaucoma drainage implantation.
Article
Ophthalmology
Yumiko Murakami, Kazuyuki Hirooka, Yuki Yuasa, Hideaki Okumichi, Kana Tokumo, Reo Kawano, Yoshiaki Kiuchi
Summary: Factors such as a history of prior surgery and higher preoperative IOP were significantly associated with a time-dependent decrease in corneal endothelial cell density (CECD) after sulcus placement during Ahmed and Baerveldt drainage device surgery. In 41 eyes of 41 patients, postsurgical CECD measurements showed a decrease of 14.6 +/- 5.4% at 24 months post-operation, with the mean intraocular pressure (IOP) decreasing from 28.4 +/- 11.6 mmHg to 12.2 +/- 5.3 mmHg.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2021)
Review
Medicine, General & Internal
Clarissa E. H. Fang, Peng Tee Khaw, Rashmi G. Mathew, Christin Henein
Summary: The study aims to assess and compare corneal endothelial cell density (ECD) loss in patients following glaucoma surgery and cataract surgery. Inclusion criteria involve adult patients with various types of glaucoma who have undergone specific types of surgeries, while excluding those with pre-existing corneal disease. The study will search electronic databases for relevant literature, extract data, and analyze outcomes to be published and disseminated in ophthalmic networks.
Article
Multidisciplinary Sciences
Manami Ohta, Makiko Wakuta, Ayano Sakuma, Mina Hasegawa, Waka Hamada, Fumiaki Higashijima, Takuya Yoshimoto, Tadahiko Ogata, Yuka Kobayashi, Kazuhiro Kimura
Summary: This study compared the early effects of cataract surgery alone and cataract surgery combined with pars plana vitrectomy (PPV) on corneal biomechanics. The results showed that corneal hysteresis temporarily decreased after cataract surgery combined with PPV, independent of intraocular pressure and central corneal thickness.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, General & Internal
Felix Mathias Wagner, Alexander Karl-Georg Schuster, Franz Grehn, Lukas Urbanek, Norbert Pfeiffer, Julia Verena Stingl, Esther Maria Hoffmann
Summary: A retrospective cohort study was conducted at the Childhood Glaucoma Center, University Medical Center Mainz in Germany to evaluate the long-term outcomes of childhood glaucoma treatment in different types of childhood glaucoma. The study found that the majority of pediatric glaucoma patients who underwent surgical intervention achieved effective intraocular pressure control postoperatively, with some patients not requiring additional medication to maintain normal eye pressure.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Yitak Kim, Won Jeong Cho, Jung Dong Kim, Hyuna Cho, Hyoung Won Bae, Chan Yun Kim, Wungrak Choi
Summary: This study investigated risk factors for corneal endothelial cell density decline and determined optimal cut-off values. Tube-iris distance was found to be the only statistically significant factor in both univariable and multivariable linear regressions.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Joanna Konopinska, Emil Saeed, Lukasz Lisowski, Kinga Golaszewska, Pawel Krasnicki, Diana Anna Dmuchowska, Iwona Obuchowska
Summary: The study compared the effects of combined surgery and cataract surgery in patients with open-angle glaucoma, and found that iStent implantation had no significant difference in terms of CECL compared to the control group 18-24 months after surgery. Therefore, iStent bypass implantation is safe for the treatment of mild-to-moderate open-angle glaucoma in terms of CECL.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Vianney Malleron, Florian Bloch, Yinka Zevering, Jean-Charles Vermion, Axelle Semler-Collery, Christophe Goetz, Jean-Marc Perone
Summary: This retrospective cohort study assessed the evolution of corneal transplantation and its indications in a specialized ophthalmology department in France over the past 21 years. The results showed an increase in the number of corneal transplantations, introduction of new surgical techniques, and changes in the prevalence of different indications. The study confirms previous findings and provides further insights into the trends in corneal transplantation.
Article
Medicine, General & Internal
Ya-Hui Wei, Yu Cai, Bonnie N. K. Choy, Bai-Bing Li, Ruo-Shi Li, Chen Xing, Xia Wang, Tian Tian, Yuan Fang, Mei Li, Ying-Zi Pan
Summary: NTG patients showed higher DCR values compared to controls, with some DCRs being negatively correlated with CCT and IOP, while others were positively correlated with these factors. The cornea was more deformable in NTG compared to HTG or controls, indicating a potential biomechanical mechanism underlying glaucomatous optic neuropathy in NTG patients.
CHINESE MEDICAL JOURNAL
(2021)
Article
Ophthalmology
Ana M. Roldan, Nazlee Zebardast, Maxwell Pistilli, Naira Khachatryan, Abhishek Payal, Hosne Begum, Pichaporn Artornsombudh, Siddharth S. Pujari, James T. Rosenbaum, H. Nida Sen, Eric B. Suhler, Jennifer E. Thorne, Nirali P. Bhatt, C. Stephen Foster, Douglas A. Jabs, Grace A. Levy-Clarke, Robert B. Nussenblatt, Jeanine M. Buchanich, John H. Kempen
Summary: This retrospective cohort study aimed to estimate the incidence of corneal endothelial transplantation (CET) and identify risk factors among patients with noninfectious ocular inflammation. The results showed that CET occurred infrequently in patients with ocular inflammation, but was associated with factors such as tube shunt surgery, hypotony, and band keratopathy.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Medicine, General & Internal
Michael X. Fu, Eduardo M. Normando, Sheila M. H. Luk, Mira Deshmukh, Faisal Ahmed, Laura Crawley, Sally Ameen, Niten Vig, Maria Francesca Cordeiro, Philip A. Bloom
Summary: This study compared the efficacy, safety, and postoperative burden of MicroShunt versus trabeculectomy in treating glaucoma. Results showed that MicroShunt had inferior efficacy in lowering IOP and medications compared to trabeculectomy, but provided a better safety profile and postoperative burden.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Tuo Meng, Jinhua Zheng, Min Chen, Yang Zhao, Hadi Sudarjat, M. R. Aji Alex, Vineet Kulkarni, Yumin Oh, Shiyu Xia, Zheng Ding, Hyounkoo Han, Nicole Anders, Michelle A. Rudek, Woon Chow, Walter Stark, Laura M. Ensign, Justin Hanes, Qingguo Xu
Summary: A high drug loading (8 to 10 wt%) and sustained release dexamethasone sodium phosphate-loaded poly(lactic acid) nanoparticle formulation was developed in this study. It successfully reversed early signs of corneal rejection and extended graft survival for up to 6 months without affecting intraocular pressure or causing ocular toxicity. Subconjunctival injection of this nanoparticle formulation shows promise for preventing and treating corneal graft rejection with improved patient adherence.
Article
Multidisciplinary Sciences
Alexandru Lavric, Valentin Popa, Hidenori Takahashi, Rossen M. Hazarbassanov, Siamak Yousefi
Summary: This study aimed to identify the association between corneal parameters and visual field damage using machine learning. Results showed that corneal parameters can predict visual functional loss caused by glaucoma, providing insights for glaucoma prediction.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Antonio Maria Fea, Martina Menchini, Alessandro Rossi, Chiara Posarelli, Lorenza Malinverni, Michele Figus
Summary: The study investigated the efficacy and safety of the XEN63 implant in open-angle glaucoma patients, showing significant reduction in intraocular pressure and the need for hypotensive medications, with good short-term safety profile.
JOURNAL OF CLINICAL MEDICINE
(2021)
