Review
Biophysics
Wei Xin Guo, Liu Fu Hu, Yun Hao Feng, Bo Zhi Chen, Xin Dong Guo
Summary: This article reviews the use of DPD in simulating the self-assembly process of pH-sensitive drug-loaded nanoparticles, exploring the factors affecting self-assembly structure and drug release. It is important for researchers to stay updated on the latest advances in DPD simulation and pH-sensitive drug nanocarrier and to investigate further applications of DPD simulation in biomedical science.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Polymer Science
Moises Bustamante-Torres, Victor H. Pino-Ramos, David Romero-Fierro, Sandra P. Hidalgo-Bonilla, Hector Magana, Emilio Bucio
Summary: The design of a new pH-sensitive hydrogel for localized prophylactic release of ciprofloxacin and silver nanoparticles was presented in this study. The hydrogel was copolymerized using gamma rays and characterized using various analytical techniques. The antimicrobial activity of the hydrogel against E. coli and MRSA was evaluated in vitro.
Article
Materials Science, Multidisciplinary
Hengxi He, Guirong Qiu, Weixiang Wang, Haibin Gu
Summary: A new amphipathic triblock polynorbornene-based copolymer was successfully synthesized using ring-opening metathesis polymerization, which exhibited dual-cargo loading capacity and oxidation/pH stimuli-responsive behavior. The polymer could release two different cargos sequentially, showing excellent biocompatibility and great potential for controllable drug release in the medical field.
Review
Polymer Science
Fabrice Ofridam, Mohamad Tarhini, Noureddine Lebaz, Emilie Gagniere, Denis Mangin, Abdelhamid Elaissari
Summary: Stimuli-responsive materials, specifically pH-responsive polymers, have attracted increasing interest due to their ability to undergo sharp and reversible changes in response to environmental pH conditions, leading to a wide range of applications in various fields.
POLYMERS FOR ADVANCED TECHNOLOGIES
(2021)
Article
Chemistry, Physical
Lu Pan, Jiahao Yang, Lan Xu
Summary: In this study, SIM-loaded bead-on-string nanofibers with core-shell structures (SBNFs) were fabricated using a coaxial electrospinning. The SBNFs showed advantages in drug release performance and biocompatibility, providing a potential application in the biomedical field. The optimal spinning parameters were determined by studying the morphology, structure, wettability, drug release performance and biocompatibility of SBNFs prepared under different spinning parameters.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2023)
Article
Engineering, Environmental
Wenxu Zhang, Xuyang Mu, Yan Xu, Sijie Li, Xiaoming Liu, Ziqiang Lei
Summary: In this study, a temperature/pH-responsive core-shell hydrogel was prepared by static template polymerization. The hydrogel exhibited good temperature responsiveness in the range of 25-55 degrees C and pH responsiveness from pH= 4 to pH= 13, with a short response time. The design of the core-shell structure enhanced the stability performance of the shell temperature-sensitive hydrogel, making it suitable for agricultural and pharmaceutical applications.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2023)
Article
Materials Science, Multidisciplinary
Chaoqun Pei, Bo Zhang, Jiuyuan Xie, Zongde Kou, Xuesong Li, Tao Feng, Baoan Sun, Weihua Wang
Summary: This study proposes a superlattice-shelled nanocrystalline core structural design to develop highly sensitive GMI sensors. Continuous Co-based amorphous microwires are fabricated using a scalable modified Taylor-Ulitovsky method and processed by picosecond lasering heat treatment. The GMI sensors made from the nanostructured Co-based microwires exhibit high sensitivity and a wide linear range, with an improved performance compared to the amorphous counterparts. The highly sensitive GMI sensor is successfully applied in geomagnetic communication to detect underground energy transmission metal pipes with a detection resolution down to pT-level weak magnetic fields.
Article
Polymer Science
Qin Zhang, Xinying Yang, Yifang Wu, Chang Liu, Hongmei Xia, Xiaoman Cheng, Yongfeng Cheng, Ying Xia, Yu Wang
Summary: The aim of this study was to prepare and evaluate kaempferol-loaded carbopol polymer hydrogel, investigate its antioxidant activity, and compare drug release under different pH conditions.
Article
Environmental Sciences
Muhammad Usman Akram, Naseem Abbas, Muhammad Farman, Suryyia Manzoor, Muhammad Imran Khan, Sameh M. Osman, Rafael Luque, Abdallah Shanableh
Summary: A therapeutic system is designed to release drugs at specific target tissues without damaging healthy cells, by using chitosan-based polymeric nanoparticles containing N-isopropyl acrylamide and 2-(di -isopropyl amino) ethyl methacrylate.
Article
Polymer Science
Marcin Mackiewicz, Serife Dagdelen, Muhammad Sagir Abubakar, Jan Romanski, Ewelina Waleka-Bargiel, Marcin Karbarz
Summary: Novel hollow hydrogel capsules were synthesized using a precipitation polymerization method, making them stimuli-sensitive and degradable. The capsules were prepared by crosslinking N-isopropylacrylamide with -N,N'-bis(acryloyl)cystine on-C = C-modified sacrificial dimethyldie-thoxysilane emulsion templates, and the silica core was removed to form the capsules. The capsules showed stability and pH sensitivity due to the presence of carboxylic groups from the crosslinking agent. The polymer network of the capsules was susceptible to degradation by the reducing agent glutathione, which allowed for controlled release of the loaded anticancer drug Doxorubicin.
POLYMER DEGRADATION AND STABILITY
(2023)
Article
Medicine, Research & Experimental
Samara Bonesso dos Reis, Juliana de Oliveira Silva, Fernanda Garcia-Fossa, Elaine Amaral Leite, Angelo Malachias, Gwenaelle Pound-Lana, Vanessa Carla Furtado Mosqueira, Monica Cristina Oliveira, Andre Luis Branco de Barros, Marcelo Bispo de Jesus
Summary: pH-sensitive liposomes showed fast accumulation and intracellular release of doxorubicin in tumor cells, leading to apoptosis. The cytotoxicity of pH-sensitive liposomes can be enhanced by chloroquine and E64d.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Polymer Science
Tahereh Najafi Ghaghelestani, Nafiseh Farhadian, Nafiseh Binesh
Summary: A core-shell lipid/polymer nanoparticle was developed for oral drug delivery with pH sensitivity and controllable drug release. Coating the nanoparticles with lipid altered their surface properties, leading to controlled drug release rates.
JOURNAL OF APPLIED POLYMER SCIENCE
(2021)
Review
Pharmacology & Pharmacy
Deniz Ceylan Tuncaboylu, Christian Wischke
Summary: Switchable polymeric materials are a major focus for parenteral controlled delivery systems, allowing for externally induced drug release adaptive to in vivo stimuli. While offering new functionalities, challenges may arise in their clinical use.
Article
Engineering, Chemical
Jie Song, Xi Li, Yuhua Niu, Lijun Chen, Zhiqiang Wei, Yidan Li, Youqian Wang
Summary: To enhance drug utilization and minimize side effects, researchers prepared (KHA/CMC-Fe3+)@CS hydrogel spheres using natural potassium humate (KHA), carboxymethyl cellulose (CMC), and chitosan (CS) as raw materials. The spheres exhibited pH-sensitivity, higher swelling in alkaline conditions, and followed Schott second-order swelling kinetics. The drug release mechanism was found to be Fickian delivery mode.
Article
Biochemistry & Molecular Biology
Lan Yi, Lu Cui, Linrui Cheng, Janos Moczo, Bela Pukanszky
Summary: Electrospun fibers containing levocetirizine were prepared from water-soluble polymers. The drug was homogeneously distributed within the fibers and showed amorphous characteristics. The release rate of the drug could be adjusted by selecting the carrier polymer, and the encapsulation efficiency was 80-90%.
