Molecular mechanisms of genomic imprinting and clinical implications for cancer

A microarray-based DNA methylation study of glioblastoma multiforme

(2014) Ramon Martinez et al.   Epigenetics

A new link between epigenetic progenitor lesions in cancer and the dynamics of signal transduction

(2011) Winston Timp et al.   CELL CYCLE

Silent beginning: Early silencing of the MED1/MBD4 gene in colorectal tumorigenesis

(2010) Giovanni Neri et al.   CANCER BIOLOGY & THERAPY

Oncogenic Role of miR-483-3p at the IGF2/483 Locus

(2010) A. Veronese et al.   CANCER RESEARCH

Systematic Protein Location Mapping Reveals Five Principal Chromatin Types in Drosophila Cells

(2010) Guillaume J. Filion et al.   CELL

Epigenetic Regulation of miR-184 by MBD1 Governs Neural Stem Cell Proliferation and Differentiation

(2010) Changmei Liu et al.   Cell Stem Cell

The transcriptional interactome: gene expression in 3D

(2010) Stefan Schoenfelder et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Gene expression profiling of drug-resistant small cell lung cancer cells by combining microRNA and cDNA expression analysis

(2010) Linlang Guo et al.   EUROPEAN JOURNAL OF CANCER

Genomic imprinting mechanisms in embryonic and extraembryonic mouse tissues

(2010) Q J Hudson et al.   HEREDITY

Transforming Growth Factor β Promotes Complexes between Smad Proteins and the CCCTC-binding Factor on theH19Imprinting Control Region Chromatin

(2010) Rosita Bergström et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Imprinted GenePEG3Inhibits Wnt Signaling and Regulates Glioma Growth

(2010) Xiuli Jiang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

G9a and Glp Methylate Lysine 373 in the Tumor Suppressor p53

(2010) Jing Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transcriptome genetics using second generation sequencing in a Caucasian population

(2010) Stephen B. Montgomery et al.   NATURE

Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis

(2010) Rajnish A. Gupta et al.   NATURE

Active DNA demethylation: many roads lead to Rome

(2010) Susan C. Wu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Regulation of imprinted expression by macro non-coding RNAs

(2010) Paulina A. Latos et al.   RNA Biology

The p53 orchestra: Mdm2 and Mdmx set the tone

(2010) Mark Wade et al.   TRENDS IN CELL BIOLOGY

Chromosome Territories

(2010) T. Cremer et al.   Cold Spring Harbor Perspectives in Biology

Distinguishing epigenetic marks of developmental and imprinting regulation

(2010) Kirsten R McEwen et al.   Epigenetics & Chromatin

Does CTCF mediate between nuclear organization and gene expression?

(2009) Rolf Ohlsson et al.   BIOESSAYS

ARHI (DIRAS3), an imprinted tumour suppressor gene, binds to importins and blocks nuclear import of cargo proteins

(2009) Shaoyi Huang et al.   BIOSCIENCE REPORTS

Yolk sac tumor but not seminoma or teratoma is associated with abnormal epigenetic reprogramming pathway and shows frequent hypermethylation of various tumor suppressor genes

(2009) Shinsuke Furukawa et al.   CANCER SCIENCE

Oncofetal H19-derived miR-675 regulates tumor suppressor RB in human colorectal cancer

(2009) Wing Pui Tsang et al.   CARCINOGENESIS

LSD1 Is a Subunit of the NuRD Complex and Targets the Metastasis Programs in Breast Cancer

(2009) Yan Wang et al.   CELL

The long noncoding RNA Kcnq1ot1 organises a lineage-specific nuclear domain for epigenetic gene silencing

(2009) L. Redrup et al.   DEVELOPMENT

Maternally-inherited Grb10 reduces placental size and efficiency

(2009) Marika Charalambous et al.   DEVELOPMENTAL BIOLOGY

Architectural roles of multiple chromatin insulators at the human apolipoprotein gene cluster

(2009) Tsuyoshi Mishiro et al.   EMBO JOURNAL

SASP reflects senescence

(2009) Andrew R J Young et al.   EMBO REPORTS

Loss of neuronatin expression is associated with promoter hypermethylation in pituitary adenoma

(2009) K Revill et al.   ENDOCRINE-RELATED CANCER

Hypermethylation of the IGF2 differentially methylated region 2 is a specific event in insulinomas leading to loss-of-imprinting and overexpression

(2009) Emelyne Dejeux et al.   ENDOCRINE-RELATED CANCER

Maternally Expressed Gene 3 (MEG3) Noncoding Ribonucleic Acid: Isoform Structure, Expression, and Functions

(2009) Xun Zhang et al.   ENDOCRINOLOGY

Beckwith–Wiedemann syndrome

(2009) Rosanna Weksberg et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Pathogenesis of choriocarcinoma: clinical, genetic and stem cell perspectives

(2009) Annie NY Cheung et al.   Future Oncology

CDKN2A,NF2, andJUNare dysregulated among other genes by miRNAs in malignant mesothelioma-A miRNA microarray analysis

(2009) Mohamed Guled et al.   GENES CHROMOSOMES & CANCER

Loss of IGF2 imprinting is associated with abrogation of long-range intrachromosomal interactions in human cancer cells

(2009) Thanh H. Vu et al.   HUMAN MOLECULAR GENETICS

Reciprocal imprinting of human GRB10 in placental trophoblast and brain: evolutionary conservation of reversed allelic expression

(2009) David Monk et al.   HUMAN MOLECULAR GENETICS

Hypomethylation of the P3 promoter is associated with up-regulation of IGF2 expression in human osteosarcoma

(2009) Yi Li et al.   HUMAN PATHOLOGY

Loss of imprinting and marked gene elevation are 2 forms of aberrant IGF2 expression in colorectal cancer

(2009) Yu-Wei Cheng et al.   INTERNATIONAL JOURNAL OF CANCER

Aberrant epigenetic modifications in the CTCF binding domain of the IGF2/H19 gene in prostate cancer compared with benign prostate hyperplasia

(2009) Paradowska   INTERNATIONAL JOURNAL OF ONCOLOGY

On the Mechanism of Multiple Lysine Methylation by the Human Mixed Lineage Leukemia Protein-1 (MLL1) Core Complex

(2009) Anamika Patel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Non-coding RNAs: regulators of disease

(2009) Ryan J Taft et al.   JOURNAL OF PATHOLOGY

CpG methylation analysis of the MEG3 and SNRPN imprinted genes in acute myeloid leukemia and myelodysplastic syndromes

(2009) Leonidas Benetatos et al.   LEUKEMIA RESEARCH

Imprinting and epigenetic changes in the early embryo

(2009) Jamie R. Weaver et al.   MAMMALIAN GENOME

Chromatin mechanisms in genomic imprinting

(2009) Slim Kacem et al.   MAMMALIAN GENOME

Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals

(2009) Mitchell Guttman et al.   NATURE

KDM1B is a histone H3K4 demethylase required to establish maternal genomic imprints

(2009) David N. Ciccone et al.   NATURE

JAK2 phosphorylates histone H3Y41 and excludes HP1α from chromatin

(2009) Mark A. Dawson et al.   NATURE

Parental origin of sequence variants associated with complex diseases

(2009) Augustine Kong et al.   NATURE

In Brief

(2009)   NATURE REVIEWS NEUROSCIENCE

PRMT5-mediated methylation of histone H4R3 recruits DNMT3A, coupling histone and DNA methylation in gene silencing

(2009) Quan Zhao et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Histone macroH2A isoforms predict the risk of lung cancer recurrence

(2009) J C Sporn et al.   ONCOGENE

Aberrant promoter methylation and expression of the imprinted PEG3 gene in glioma

(2009) Susumu OTSUKA et al.   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

Regulation of DNMT1 stability through SET7-mediated lysine methylation in mammalian cells

(2009) P.-O. Esteve et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression

(2009) Ahmad M. Khalil et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1

(2009) M. Tahiliani et al.   SCIENCE

The Human Retinoblastoma Gene Is Imprinted

(2009) Deniz Kanber et al.   PLoS Genetics

Cohesin Is Required for Higher-Order Chromatin Conformation at the Imprinted IGF2-H19 Locus

(2009) Raffaella Nativio et al.   PLoS Genetics

The atypical mammalian ligand Delta-like1 (Dlk1) can regulate Notch signalling in Drosophila

(2008) Sarah J Bray et al.   BMC DEVELOPMENTAL BIOLOGY

Loss of imprinting of IGF2 correlates with hypermethylation of the H19 differentially methylated region in hepatoblastoma

(2008) S Honda et al.   BRITISH JOURNAL OF CANCER

Imprinted tumor suppressor genesARHI andPEG3 are the most frequently down-regulated in human ovarian cancers by loss of heterozygosity and promoter methylation

(2008) Weiwei Feng et al.   CANCER

CTCFL/BORIS Is a Methylation-Independent DNA-Binding Protein That Preferentially Binds to the Paternal H19 Differentially Methylated Region

(2008) P. Nguyen et al.   CANCER RESEARCH

A Phase I Biological Study of MG98, an Oligodeoxynucleotide Antisense to DNA Methyltransferase 1, in Patients with High-Risk Myelodysplasia and Acute Myeloid Leukemia

(2008) R. B. Klisovic et al.   CLINICAL CANCER RESEARCH

Mature miR-184 as Potential Oncogenic microRNA of Squamous Cell Carcinoma of Tongue

(2008) T.-S. Wong et al.   CLINICAL CANCER RESEARCH

Altered MicroRNA Expression in Cervical Carcinomas

(2008) J.-W. Lee et al.   CLINICAL CANCER RESEARCH

A Maternal-Zygotic Effect Gene, Zfp57, Maintains Both Maternal and Paternal Imprints

(2008) Xiajun Li et al.   DEVELOPMENTAL CELL

Polycomb Group Proteins Ezh2 and Rnf2 Direct Genomic Contraction and Imprinted Repression in Early Mouse Embryos

(2008) Rémi Terranova et al.   DEVELOPMENTAL CELL

A mono-allelic bivalent chromatin domain controls tissue-specific imprinting at Grb10

(2008) Lionel A Sanz et al.   EMBO JOURNAL

G9a/GLP complexes independently mediate H3K9 and DNA methylation to silence transcription

(2008) Makoto Tachibana et al.   EMBO JOURNAL

PR-SET7 and SUV4-20H regulate H4 lysine-20 methylation at imprinting control regions in the mouse

(2008) Maëlle Pannetier et al.   EMBO REPORTS

Changes in genomic imprinting and gene expression associated with transformation in a model of human osteosarcoma

(2008) Yi Li et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

A novel 6C assay uncovers Polycomb-mediated higher order chromatin conformations

(2008) V. K. Tiwari et al.   GENOME RESEARCH

Hypomethylated and hypermethylated profiles of H19DMR are associated with the aberrant imprinting of IGF2 and H19 in human hepatocellular carcinoma

(2008) Jing Wu et al.   GENOMICS

Somatically acquired hypomethylation of IGF2 in breast and colorectal cancer

(2008) Yoko Ito et al.   HUMAN MOLECULAR GENETICS

Frequent biallelic inactivation and transcriptional silencing of theDIRAS3 gene at 1p31 in oligodendroglial tumors with 1p loss

(2008) Markus J. Riemenschneider et al.   INTERNATIONAL JOURNAL OF CANCER

TIP60 Represses Transcriptional Activity of p73β via an MDM2-bridged Ternary Complex

(2008) Jung-Woong Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selective Loss ofMEG3Expression and Intergenic Differentially Methylated Region Hypermethylation in theMEG3/DLK1Locus in Human Clinically Nonfunctioning Pituitary Adenomas

(2008) Roger Gejman et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

DNA methylation profiles in diffuse large B-cell lymphoma and their relationship to gene expression status

(2008) B L Pike et al.   LEUKEMIA

Imprinted noncoding RNAs

(2008) Jo Peters et al.   MAMMALIAN GENOME

Origin, Evolution, and Biological Role of miRNA Cluster in DLK-DIO3 Genomic Region in Placental Mammals

(2008) E. A. Glazov et al.   MOLECULAR BIOLOGY AND EVOLUTION

Frequency and Timing of Loss of Imprinting at 11p13 and 11p15 in Wilms' Tumor Development

(2008) K. W. Brown et al.   MOLECULAR CANCER RESEARCH

Kcnq1ot1 Antisense Noncoding RNA Mediates Lineage-Specific Transcriptional Silencing through Chromatin-Level Regulation

(2008) Radha Raman Pandey et al.   MOLECULAR CELL

The impact of microRNAs on protein output

(2008) Daehyun Baek et al.   NATURE

IGFBP-4 is an inhibitor of canonical Wnt signalling required for cardiogenesis

(2008) Weidong Zhu et al.   NATURE

Epigenetic silencing of tumour suppressor gene p15 by its antisense RNA

(2008) Wenqiang Yu et al.   NATURE

Induced ncRNAs allosterically modify RNA-binding proteins in cis to inhibit transcription

(2008) Xiangting Wang et al.   NATURE

Histone H2A.Z and DNA methylation are mutually antagonistic chromatin marks

(2008) Daniel Zilberman et al.   NATURE

Endogenous siRNAs from naturally formed dsRNAs regulate transcripts in mouse oocytes

(2008) Toshiaki Watanabe et al.   NATURE

Pseudogene-derived small interfering RNAs regulate gene expression in mouse oocytes

(2008) Oliver H. Tam et al.   NATURE

Hypomethylation of multiple imprinted loci in individuals with transient neonatal diabetes is associated with mutations in ZFP57

(2008) Deborah J G Mackay et al.   NATURE GENETICS

Distinct Methylation Changes at the IGF2-H19 Locus in Congenital Growth Disorders and Cancer

(2008) Adele Murrell et al.   PLoS One

The H19 locus acts in vivo as a tumor suppressor

(2008) T. Yoshimizu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Air Noncoding RNA Epigenetically Silences Transcription by Targeting G9a to Chromatin

(2008) T. Nagano et al.   SCIENCE

Bidirectional Transcription Directs Both Transcriptional Gene Activation and Suppression in Human Cells

(2008) Kevin V. Morris et al.   PLoS Genetics

Epigenetics and Complex Disease: From Etiology to New Therapeutics

(2007) Carolyn Ptak et al.   Annual Review of Pharmacology and Toxicology