Can we intervene in human ageing?

Longevity pathways converge on autophagy genes to regulate life span inCaenorhabditis elegans

(2014) Márton L. Tóth et al.   Autophagy

Telomerase-Based Pharmacologic Enhancement of Antiviral Function of Human CD8+ T Lymphocytes

(2014) S. R. Fauce et al.   JOURNAL OF IMMUNOLOGY

Separating cause from effect: how does insulin/IGF signalling control lifespan in worms, flies and mice?

(2010) M. D. W. Piper et al.   JOURNAL OF INTERNAL MEDICINE

How Does Proliferative Homeostasis Change With Age? What Causes It and How Does It Contribute to Aging?

(2009) J. Campisi et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Kleemeier Award Lecture 2008--The Canary in the Coal Mine: Telomeres and Human Healthspan

(2009) R. B. Effros   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Vaccine Prevention of Maternal Cytomegalovirus Infection

(2009) Robert F. Pass et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cellular senescence, ageing and disease

(2008) D. G. A. Burton   AGE

Microwave-assisted synthesis of 5-aminopyrazol-4-yl ketones and the p38MAPK inhibitor RO3201195 for study in Werner syndrome cells

(2008) Mark C. Bagley et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A transcriptomic analysis of the EK1.Br strain of human fibroblastoid keratocytes: The effects of growth, quiescence and senescence

(2008) David Kipling et al.   EXPERIMENTAL EYE RESEARCH

Reversal of age-associated thymic atrophy: Treatments, delivery, and side effects

(2008) Richard Aspinall et al.   EXPERIMENTAL GERONTOLOGY

Against the oxidative damage theory of aging: superoxide dismutases protect against oxidative stress but have little or no effect on life span in Caenorhabditis elegans

(2008) R. Doonan et al.   GENES & DEVELOPMENT

Progressive Telomere Shortening of Epstein‐Barr Virus–Specific Memory T Cells during HIV Infection: Contributor to Exhaustion?

(2008) Debbie van Baarle et al.   JOURNAL OF INFECTIOUS DISEASES

Energy Restriction Impairs Natural Killer Cell Function and Increases the Severity of Influenza Infection in Young Adult Male C57BL/6 Mice

(2008) Barry W. Ritz et al.   JOURNAL OF NUTRITION

Combined treatment with statins and aminobisphosphonates extends longevity in a mouse model of human premature aging

(2008) Ignacio Varela et al.   NATURE MEDICINE

Phenotype and Course of Hutchinson–Gilford Progeria Syndrome

(2008) Melissa A. Merideth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Critical pathways in cellular senescence and immortalization revealed by gene expression profiling

(2008) A L Fridman et al.   ONCOGENE

A farnesyltransferase inhibitor prevents both the onset and late progression of cardiovascular disease in a progeria mouse model

(2008) B. C. Capell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

FOXO3A genotype is strongly associated with human longevity

(2008) B. J. Willcox et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Feeding, fecundity and lifespan in female Drosophila melanogaster

(2008) A. I Barnes et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice

(2007) Colin Selman et al.   FASEB JOURNAL