期刊
EXPERT REVIEW OF VACCINES
卷 12, 期 10, 页码 1173-1193出版社
TAYLOR & FRANCIS LTD
DOI: 10.1586/14760584.2013.836909
关键词
antigen presenting cells; cancer vaccines; HBV; HPV; ISCOMs; liposomes; nanoparticles; polymers; virus-like particles
类别
资金
- Italian Ministry for University and Research [2010H834LS]
- European Community [201433]
Effective delivery of tumor antigens to APCs is one of the key steps for eliciting a strong and durable immune response to tumors. Several cancer vaccines have been evaluated in clinical trials, based on soluble peptides, but results have not been fully satisfactory. To improve immunogenicity particles provide a valid strategy to display and/or incorporate epitopes which can be efficiently targeted to APCs for effective induction of adaptive immunity. In the present review, we report some leading technologies for developing particulate vaccines employed in cancer immunotherapy, highlighting the key parameters for a rational design to elicit both humoral and cellular responses.
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