Article
Chemistry, Medicinal
Chao Yang, Wansheng Xie, Heqian Zhang, Wenjian Xie, Tiantian Tian, Zhiwei Qin
Summary: Dengue is an acute tropical infectious disease transmitted by mosquitoes, posing a major challenge to global public health. The lack of clinically proven specific drugs for prevention and treatment is mainly due to the incomplete understanding of the pathogenesis of dengue fever.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Public, Environmental & Occupational Health
Gabriela Paz-Bailey, Laura Adams, Joshua M. Wong, Katherine A. Poehling, Wilbur H. Chen, Veronica McNally, Robert L. Atmar, Stephen H. Waterman
Summary: Dengue is a vectorborne infectious disease caused by closely related dengue viruses, transmitted mainly by Aedes mosquitoes. The Dengvaxia vaccine is recommended by ACIP for children aged 9-16 with previous dengue infection in endemic areas, as it is safe and effective in preventing severe dengue. Prior natural infection is important, as vaccination may increase the risk of severe dengue in individuals experiencing their first natural infection after vaccination.
MMWR RECOMMENDATIONS AND REPORTS
(2021)
Article
Multidisciplinary Sciences
Amalia Soares Vieira de Vasconcelos, Josenildo Silva de Lima, Rodrigo Tomas Nogueira Cardoso
Summary: Epidemiological models that consider arthropod vectors can help reduce the use of insecticides and social costs, and studying dengue is important in this context.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Shinji Kasai, Kentaro Itokawa, Nozomi Uemura, Aki Takaoka, Shogo Furutani, Yoshihide Maekawa, Daisuke Kobayashi, Nozomi Imanishi-Kobayashi, Michael Amoa-Bosompem, Katsunori Murota, Yukiko Higa, Hitoshi Kawada, Noboru Minakawa, Tran Chi Cuong, Nguyen Thi Yen, Tran Vu Phong, Sath Keo, Kroesna Kang, Kozue Miura, Lee Ching Ng, Hwa-Jen Teng, Samuel Dadzie, Sri Subekti, Kris Cahyo Mulyatno, Kyoko Sawabe, Takashi Tomita, Osamu Komagata
Summary: Aedes aegypti, the main mosquito vector for dengue and other arboviral infectious diseases, has developed high levels of pyrethroid resistance in populations collected from Vietnam and Cambodia. This resistance could pose a serious threat to the control of dengue fever and other Aedes-borne infectious diseases.
Review
Virology
Romchat Kraivong, Nuntaya Punyadee, M. Kathryn Liszewski, John P. Atkinson, Panisadee Avirutnan
Summary: Dengue is a mosquito-borne viral disease that can lead to significant health and economic burdens globally. The dengue virus has four serotypes, with primary infections often being asymptomatic or causing mild symptoms, while secondary infections with a different serotype can result in severe disease. The complement system and lectin pathway play key roles in the pathogenesis of dengue, with differences in viral glycan recognition influencing the efficiency of virus binding and neutralization.
Article
Medicine, Research & Experimental
Ruixue Hou, Lewis E. Tomalin, Jessica Pintado Silva, Seunghee Kim-Schulze, Stephen S. Whitehead, Ana Fernandez-Sesma, Anna P. Durbin, Mayte Suarez-Farinas
Summary: Understanding the immune response to dengue virus is crucial for dengue vaccine development. This study showed that the tetravalent vaccine has better protective effects against DENV compared to the trivalent admixture. Additionally, differences in immune responses between Black and White participants were observed.
Article
Microbiology
Roenick P. Olmo, Yaovi M. H. Todjro, Eric R. G. R. Aguiar, Joao Paulo P. de Almeida, Flavia V. Ferreira, Juliana N. Armache, Isaque J. S. de Faria, Alvaro G. A. Ferreira, Siad C. G. Amadou, Ana Teresa S. Silva, Katia P. R. de Souza, Ana Paula P. Vilela, Antinea Babarit, Cheong H. Tan, Mawlouth Diallo, Alioune Gaye, Christophe Paupy, Judicael Obame-Nkoghe, Tessa M. M. Visser, Constantianus J. M. Koenraadt, Merril A. Wongsokarijo, Ana Luiza C. Cruz, Mariliza T. Prieto, Maisa C. P. Parra, Mauricio L. Nogueira, Vivian Avelino-Silva, Renato N. N. Mota, Magno A. Z. Borges, Betania P. Drumond, Erna G. G. Kroon, Mario Recker, Luigi Sedda, Eric Marois, Jean-Luc Imler, Joao T. Marques
Summary: The study analyzed the mechanism by which insect-specific viruses affect mosquito vector competence to transmit dengue virus to humans. Two mosquito-specific viruses, Phasi Charoen-like virus (PCLV) and Humaita Tubiacanga virus (HTV), were found to be the most abundant in Aedes aegypti worldwide. The presence of HTV and PCLV increased the ability of mosquitoes to transmit dengue virus and Zika virus to a vertebrate host.
NATURE MICROBIOLOGY
(2023)
Article
Multidisciplinary Sciences
Talya Shragai, Juliana Perez-Perez, Marcela del Pilar Quimbayo-Forero, Raul Rojo, Laura C. Harrington, Guillermo Rua-Uribe
Summary: Dengue is becoming an increasing global threat in rapidly growing urban areas. This study analyzes nine years of dengue case data in Medellin, Colombia and finds that changes in accessibility and usage of public transit are correlated with changes in the spread and magnitude of localized outbreaks. Locations closer to and with greater utilization of public transit have higher dengue incidence, with a stronger effect observed in lower socioeconomic status areas. These results emphasize the importance of public health services in conjunction with urban growth.
SCIENTIFIC REPORTS
(2022)
Article
Infectious Diseases
Lauren A. Castro, Nicholas Generous, Wei Luo, Ana Pastore y Piontti, Kaitlyn Martinez, Marcelo F. C. Gomes, Dave Osthus, Geoffrey Fairchild, Amanda Ziemann, Alessandro Vespignani, Mauricio Santillana, Carrie A. Manore, Sara Y. Del Valle
Summary: Dengue virus poses a significant public health challenge in Brazil, with seasonal dynamics hindering preparation efforts. A framework was presented to characterize weekly dengue activity in Brazil from 2010-2016, with climate factors playing a key role in seasonal outbreaks. Remote sensing and movement patterns were found to be useful proxies for predicting outbreak properties.
PLOS NEGLECTED TROPICAL DISEASES
(2021)
Article
Entomology
Wondemeneh Mekuriaw, Solomon Kinde, Bezabih Kindu, Yibeyin Mulualem, Girma Hailu, Araya Gebresilassie, Chalachw Sisay, Fitsum Bekele, Hiwot Amare, Mesfin Wossen, Adugna Woyessa, Chad L. Cross, Louisa A. Messenger
Summary: Dengue Fever (DF) is a viral disease transmitted by mosquitoes, and an outbreak occurred in the Afar Region, Ethiopia in 2019. The study found that Aedes aegypti mosquitoes were responsible for transmitting DF, and most cases occurred in individuals aged 15-49. The results emphasize the need for control measures targeting Aedes mosquitoes and improved entomological surveillance to prevent future outbreaks.
Article
Multidisciplinary Sciences
Mona Gaber, Alzahraa Abdelraouf Ahmad, Asmaa M. El-Kady, Mohammed Tolba, Yutaka Suzuki, Shereen M. Mohammed, Nahed Ahmed Elossily
Summary: This study aimed to investigate the prevalence of dengue virus infection in Upper Egypt in 2016 and identify the mosquito vector involved. The results showed that dengue virus was circulating in both human and mosquito populations, with DENV-1 being the most prevalent serotype. It was the first report of serotyping of dengue virus infection in an outbreak in Egypt using the RT-LAMP assay.
Article
Environmental Sciences
Cory W. Morin, Samuel Sellers, Kristie L. Ebi
Summary: This study explored the relationship between seasonal climate variability and dengue fever (DF) in Brazil using temperature-based models. The results showed that areas with higher mosquito survival probabilities and shorter extrinsic incubation periods (EIPs) were more likely to have DF case reports, but with significant intra-annual variability. The study also extrapolated the findings to the Americas, mapping the seasonal change in the range of areas suitable for dengue virus transmission and the population living in those areas using climate data from the past decade (2010-2019).
ENVIRONMENTAL RESEARCH LETTERS
(2022)
Article
Infectious Diseases
Van-Hau Nguyen, Tran Thi Tuyet-Hanh, James Mulhall, Hoang Van Minh, Trung Duong, Nguyen Van Chien, Nguyen Thi Trang Nhung, Vu Hoang Lan, Hoang Ba Minh, Do Cuong, Nguyen Ngoc Bich, Nguyen Huu Quyen, Tran Nu Quy V. Linh, Nguyen Thi Tho, Ngu Duy V. Nghia, Le Van Quoc Anh, Diep T. M. V. Phan, Nguyen Quoc Viet Hung, Mai Thai V. Son
Summary: This study developed a deep learning model for weather-based prediction of dengue fever in Vietnam. The LSTM-ATT model demonstrated the highest performance and accurately predicted dengue fever incidence and outbreak months. This study highlights the importance of using deep learning models for disease forecasting in the context of climate change.
PLOS NEGLECTED TROPICAL DISEASES
(2022)
Editorial Material
Medicine, General & Internal
Senanayake Abeysinghe Kularatne, Chamara Dalugama
Summary: Dengue is a mosquito-borne infection that is highly prevalent in tropical and subtropical climates. It can range from asymptomatic infection to severe infection with multi-organ failure. Dengue haemorrhagic fever is a clinical subtype characterized by plasma leak, which requires careful monitoring and fluid resuscitation. Dengue fever can also affect various organs, including the heart, liver, kidney, and brain. Ongoing research on vaccines and vector control aims to prevent this globally significant infection.
Article
Infectious Diseases
Ana Paula Razal Dalvi, Gerusa Gibson, Alberto Novaes Ramos Jr, Katia V. Bloch, Geziel dos Santos de Sousa, Thiago Luiz Nogueira da Silva, Jose Ueleres Braga, Marcia C. Castro, Guilherme Loureiro Werneck
Summary: This study aimed to identify sociodemographic and environmental risk factors for the occurrence of Zika, dengue, and chikungunya in adolescents. The study found that adolescents with better socioeconomic conditions had a lower risk of infection. Additionally, a higher risk of arboviral diseases was associated with a high mosquito infestation index in the school's region. These findings can contribute to the implementation of control measures in population groups and priority locations.
PLOS NEGLECTED TROPICAL DISEASES
(2023)
