☆ 4.2 Review

Current frontiers in clinical research application of MALDI imaging mass spectrometry

EXPERT REVIEW OF PROTEOMICS (2013)

期刊

EXPERT REVIEW OF PROTEOMICS

卷 10, 期 3, 页码 259-273

出版社

TAYLOR & FRANCIS LTD

DOI: 10.1586/EPR.13.19

关键词

clinical proteomics; imaging mass spectrometry; MALDI imaging mass spectrometry; molecular pathology; tissue protein analysis

类别

Biochemical Research Methods

资金

BMBF [0315508A, 01IB10004E]
Deutsche Forschungsgemeinschaft [SFB 824 TP B1, SFB 824 TP Z2, WA 1656/3-1]

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摘要

Imaging mass spectrometry (IMS) is still a relatively young imaging technique that allows molecular mapping of diverse biomolecules in their natural environment. Furthermore, IMS allows for the direct correlation of tissue histology and proteomic, metabolomic or lipidomic information. In recent years, increasing efforts have been made in the development and improvement of IMS, which aid its application in clinical research. In this article, current frontiers of clinical research applications of IMS are discussed in the context of recent developments of IMS technology. Critical stages in planning and realizing clinical studies are highlighted. Finally, a selection of recent prominent examples for successful clinical applications of IMS is presented.

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