期刊
EXPERT REVIEW OF NEUROTHERAPEUTICS
卷 14, 期 1, 页码 9-18出版社
TAYLOR & FRANCIS LTD
DOI: 10.1586/14737175.2014.864952
关键词
multiple sclerosis; primary prevention; prospective biobank studies; randomized controlled trials; ultraviolet B (UVB) radiation; vitamin D
资金
- Biogen Idec
- Merck Serono
- Sanofi-Aventis
- Swedish Association of Neurologically Disabled
This article briefly introduces the basics of multiple sclerosis' (MS) clinical hallmarks and pathophysiology. Vitamin D is presented, including its metabolism and effects on the immune system. The epidemiological observations linking vitamin D to MS range from a half century old findings of latitude gradients and migrational risk patterns to modern, nested, case-control biobank studies. These observations show an association without doubt although causation has yet to be proven. Vitamin D as a treatment for MS is an emerging concept and both current and anticipated data will be covered. Lastly, we discuss future challenges, ideas on how to move from association to causation, and the prospect of primary prevention of this disabling disease.
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