期刊
EXPERT REVIEW OF NEUROTHERAPEUTICS
卷 13, 期 3, 页码 251-260出版社
TAYLOR & FRANCIS LTD
DOI: 10.1586/ERN.13.12
关键词
birth; breastfeeding; disease-modifying drugs; multiple sclerosis; pregnancy; safety
资金
- Canadian Institutes of Health Research
- Multiple Sclerosis Society of Canada
- University of British Columbia (Faculty of Medicine)
- Albert and Mary Steiner Summer Research Award
- MS Society of Canada Scientific Research Foundation
- CIHR
- Biogen-Idec
- Teva Neurosciences
- Michael Smith Foundation for Health Research
- Canada Research Chair for Neuroepidemiology and Multiple Sclerosis
- US National Multiple Sclerosis Society
- UK MS Trust
Expert Rev. Neurother. 13(3), 251-261 (2013) When contemplating a pregnancy, women treated for multiple sclerosis (MS) with a disease-modifying drug must decide to discontinue their medication before conception or risk exposing their unborn child to potential drug toxicity. Few studies exist as reference for patients and physicians, and of those available, the majority are less than ideal due to real-world constraints, ethical issues and methodological shortcomings. The authors provide a brief summary of existing animal and human data with current recommendations regarding the safety of IFN-beta, glatiramer acetate, natalizumab, mitoxantrone, fingolimod and teriflunomide during pregnancy and lactation in women with MS. We also assess the quality, strengths and limitations of the existing studies including challenges with study design. The investigation of outcomes such as spontaneous abortion and congenital anomalies are highlighted with potential methodological improvements for future studies on drug safety in pregnancy suggested. The authors explore the pharmacokinetics and pharmacodynamics of the MS disease-modifying drugs for their possible mechanistic role in fetal harm and discuss the potential role of clinical trials. Future pharmacovigilance studies should continue to pursue multicenter collaboration with an emphasis on appropriate study design.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据