期刊
EXPERT REVIEW OF NEUROTHERAPEUTICS
卷 12, 期 11, 页码 1339-1350出版社
TAYLOR & FRANCIS LTD
DOI: 10.1586/ERN.12.127
关键词
Alzheimer's disease; biomarker; cytokine; dementia; depression; inflammation; mild cognitive impairment
资金
- Health Resources and Services Administration [6UB4HP19215]
Depression, mild cognitive impairment (MCI) and dementia are highly prevalent conditions that are increasing exponentially with similarly expanding social, medical and economic burdens. While there is a clear clinical connection between these three disorders, the mechanism of action that links them is less well understood. The lack of well-accepted biomarkers results in high levels of diagnostic subjectivity, which then greatly impacts research results when attempting to further explore their association. There is also a variety of clinical presentations of depressive syndromes, particularly in the elderly; each one may be associated with a different risk in the progression from MCI to different types of dementia. The diagnostic challenges, the importance of biomarkers and the discussion of inflammation as a possible link between depression, MCI and dementia are examined in this article.
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