期刊
EXPERT REVIEW OF NEUROTHERAPEUTICS
卷 12, 期 3, 页码 297-306出版社
TAYLOR & FRANCIS LTD
DOI: 10.1586/ERN.12.13
关键词
animal models; hormones; ion channels; migraine; prophylaxis; spreading depression
资金
- NIH [NS061505]
- Harvard Catalyst - The Harvard Clinical and Translational Science Center (NIH) [UL1 RR 025758]
- Harvard University
- American Heart Association [SDG 2610275]
Migraine, particularly with aura, is a genetically heterogeneous disorder of ion channels, pumps or transporters associated with increased cortical excitability. Spreading depression, as one reflection of hyperexcitability, is the electrophysiological event underlying aura symptoms and a trigger for headache. Endogenous (e.g., genes and hormones) and exogenous factors (e.g., drugs) modulating migraine susceptibility have also been shown to modulate spreading depression susceptibility concordantly, suggesting that spreading depression can be a relevant therapeutic target in migraine. In support of this, several migraine prophylactic drugs used in clinical practice have been shown to suppress spreading depression susceptibility as a probable mechanism of action, despite belonging to widely different pharmacological classes. Hence, susceptibility to spreading depression can be a useful preclinical model with good positive and negative predictive value for drug screening.
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