Article
Clinical Neurology
Daphne Voineskos, Daniel M. Blumberger, Nigel C. Rogasch, Reza Zomorrodi, Faranak Farzan, George Foussias, Tarek K. Rajji, Zafiris J. Daskalakis
Summary: The study found that repetitive transcranial magnetic stimulation (rTMS) can reduce neurophysiological markers of inhibition and excitability in treating treatment resistant depression (TRD), revealing potential important neurophysiological mechanisms of action for rTMS.
CLINICAL NEUROPHYSIOLOGY
(2021)
Article
Behavioral Sciences
Andrew M. Fukuda, Jee Won Diane Kang, Asi Polly Gobin, Eric Tirrell, Fatih Kokdere, Linda L. Carpenter
Summary: The study found that TMS treatment significantly improved anhedonia in depressed patients and that the severity of anhedonia was significantly correlated with other depressive symptoms. However, baseline severity of anhedonia was not a significant predictor of clinical outcome.
BRAIN AND BEHAVIOR
(2021)
Review
Neurosciences
Weronika Debowska, Magdalena Wiedlocha, Marta Debowska, Zuzanna Kownacka, Piotr Marcinowicz, Agata Szulc
Summary: Drug-resistant mental disorders are a significant medical and social issue. Modern psychiatry is exploring novel treatment methods, such as combining transcranial magnetic stimulation and ketamine, to address this challenge and enhance treatment efficacy.
FRONTIERS IN NEUROSCIENCE
(2023)
Review
Medicine, General & Internal
Robert L. Folmer
Summary: Transcranial magnetic stimulation (TMS) has been studied for 20 years as a potential treatment for chronic tinnitus. Many studies have shown that repetitive TMS (rTMS) can effectively reduce the severity of tinnitus and its associated conditions. However, there is a debate about the effectiveness of rTMS compared to sham rTMS. There are several unresolved issues in this field that need to be addressed.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Clinical Neurology
Marta Cano, Erik Lee, Christopher Polanco, Tracy Barbour, Kristen K. Ellard, Blake Andreou, Sofia Uribe, Michael E. Henry, Stephen Seiner, Narcis Cardoner, Carles Soriano-Mas, Joan A. Camprodon
Summary: In this study, the authors compared the brain volumetric changes in patients with treatment-resistant depression (TRD) after receiving electroconvulsive therapy (ECT) or repetitive transcranial magnetic stimulation (rTMS). The results showed that patients who received ECT exhibited greater volumetric increase in certain brain regions compared to those who received rTMS. However, the changes in brain volume were not associated with clinical improvement.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Clinical Neurology
Hannah Ford, Lisa Hahn, Patrick Clarke, Shane Gill, Ben Carnell, Cherrie Galletly
Summary: In this study, it was found that 15-minute and 30-minute rTMS treatments showed no significant difference in partial response, response, and remission rates for treatment resistant depression, indicating that shorter treatment sessions were just as effective as longer sessions.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Clinical Neurology
Peter Stohrmann, Godber Mathis Godbersen, Murray Bruce Reed, Jakob Unterholzner, Manfred Klobl, Pia Baldinger-Melich, Thomas Vanicek, Andreas Hahn, Rupert Lanzenberger, Siegfried Kasper, Georg S. Kranz
Summary: This longitudinal study investigated the effect of bilateral sequential theta-burst stimulation (TBS) on functional connectivity (FC) in treatment-resistant depression (TRD). Results showed that both active and sham stimulation groups exhibited reductions in depression scores, with no significant difference between the two groups. Baseline FC between the left dorsolateral prefrontal cortex (DLPFC) and the subgenual cingulate cortex (sgACC) was correlated with changes in depression severity. TBS significantly reduced FC between the left stimulation target and bilateral anterior insula, highlighting the effect on the salience network.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Review
Clinical Neurology
Adam Harris, John Reece
Summary: This meta-analysis found an overall effect size of d = 1.17, 95% CI [0.89-1.45] for TMS as a treatment for PTSD. Analysis of moderators showed that high frequency TMS (d = 1.44) had a significantly larger treatment effect compared to low frequency TMS (d = 0.72), but there was no significant difference between TMS targeting the left dorsolateral prefrontal cortex (DLPFC) and the right DLPFC, and larger treatment doses were not associated with stronger treatment effects.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Psychiatry
Qi Wang, Hongfei Huang, Dongdong Li, Yitong Wang, Na Qi, Yihong Ci, Tianchao Xu
Summary: This study investigated the antidepressant and antisuicidal effects of an intensive rTMS protocol for treatment-resistant depression patients with suicidal ideation. The results showed significant improvement in depression symptoms and a high response rate for suicidal ideation. The protocol also showed promise as a treatment for military veteran populations.
ASIAN JOURNAL OF PSYCHIATRY
(2022)
Article
Clinical Neurology
Bhedita J. Seewoo, Jennifer Rodger, Mark A. Demitrack, Karen L. Heart, John D. Port, Jeffrey R. Strawn, Paul E. Croarkin
Summary: The neurobiology of treatment-resistant depression (TRD) in adolescents and the impact of treatment on this neurobiology is poorly understood. This study found that adolescents with TRD and major depressive disorder (MDD) had reduced amygdala volumes compared to healthy adolescents. However, six weeks of active transcranial magnetic stimulation (TMS) increased amygdala volumes and the volume of the stimulated dorsolateral prefrontal cortex in adolescents with TRD.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2022)
Review
Clinical Neurology
Saydra Wilson, Paul E. Croarkin, Scott T. Aaronson, Linda L. Carpenter, Michelle Cochran, Debra J. Stultz, F. Andrew Kozel
Summary: The existing literature on preservation TMS shows low quality in terms of efficacy, but provides clear support for effectiveness and safety. Due to the lack of effective alternatives, patients who respond to acute TMS therapy may require preservation TMS. More studies on preservation TMS are urgently needed.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Clinical Neurology
Igor Filipcic, Ivona Simunovic Filipcic, Strahimir Sucic, Zeljko Milovac, Natko Geres, Katarina Matic, Mirela Celic-Ruzic, Sandra Zecevic Penic, Ivana Orgulan, Vladimir Pozgaj, Zarko Bajic
Summary: The study found that twice-daily adTMS for 10 days seems to be safe and effective, with rapid clinical benefits during the first week of treatment. These promising results warrant further investigation in larger randomized clinical trials comparing adTMS with the standard dTMS protocol.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2021)
Article
Materials Science, Biomaterials
Hamzah Magsood, R. L. Hadimani
Summary: Transcranial magnetic stimulation (TMS) is a non-invasive technique used for diagnosis and treatment of neurological conditions, but the lack of realistic physical models has hindered the development of new protocols. A research team has developed an accurate brain and head phantom for testing TMS effects, created through segmentation of MRI images and filling with conductive polymer, with SEM images and voltage measurements confirming its anatomical accuracy.
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2021)
Article
Clinical Neurology
Carl Johan Ekman, Katarzyna Popiolek, Robert Boden, Axel Nordenskjold, Johan Lundberg
Summary: This study investigated the effectiveness and tolerability of intermittent Theta-burst stimulation (iTBS) in a clinical setting. The results showed that iTBS was safe and well-tolerated, and the response rate was similar to that reported in clinical trials. Older age and milder illness predicted a better treatment response.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Review
Cell Biology
Davide Cappon, Tim den Boer, Caleb Jordan, Wanting Yu, Eran Metzger, Alvaro Pascual-Leone
Summary: This review examines the efficacy of transcranial magnetic stimulation (TMS) for the treatment of geriatric depression (GD), highlighting the heterogeneity among studies in terms of TMS dosage and observed clinical efficacy. The findings underscore the need for optimizing TMS dosage by considering the unique clinical features of GD. Novel approaches for optimizing TMS protocols for depression are showcased, and the possibility of a standardized TMS protocol tailored for GD treatment is discussed.
AGEING RESEARCH REVIEWS
(2022)
Article
Behavioral Sciences
McLeod Frampton Gwynette, Danielle W. Lowe, Erin A. Henneberry, Gregory L. Sahlem, Melanie Gail Wiley, Hussam Alsarraf, Sarah Brice Russo, Jane E. Joseph, Philipp M. Summers, Laura Lohnes, Mark S. George
Article
Clinical Neurology
Daniel N. Cook, Sean Thompson, Sasha Stomberg-Firestein, Marom Bikson, Mark S. George, Dorothea D. Jenkins, Bashar W. Badran
Article
Clinical Neurology
Mark S. George
Article
Neurosciences
Bashar W. Badran, Dorothea D. Jenkins, Daniel Cook, Sean Thompson, Morgan Dancy, William H. DeVries, Georgia Mappin, Philipp Summers, Marom Bikson, Mark S. George
FRONTIERS IN HUMAN NEUROSCIENCE
(2020)
Article
Clinical Neurology
Kevin A. Caulfield, Bashar W. Badran, William H. DeVries, Philipp M. Summers, Emma Kofmehl, Xingbao Li, Jeffrey J. Borckardt, Marom Bikson, Mark S. George
Article
Clinical Neurology
Ryan D. Webler, Carmen Hamady, Chris Molnar, Kevin Johnson, Leo Bonilha, Berry S. Anderson, Claartje Bruin, Daryl E. Bohning, Mark S. George, Ziad Nahas
Letter
Clinical Neurology
Kevin A. Caulfield, Bashar W. Badran, Xingbao Li, Marom Bikson, Mark S. George
Review
Clinical Neurology
Simone Rossi, Andrea Antal, Sven Bestmann, Marom Bikson, Carmen Brewer, Jurgen Brockmoller, Linda L. Carpenter, Massimo Cincotta, Robert Chen, Jeff D. Daskalakis, Vincenzo Di Lazzaro, Michael D. Fox, Mark S. George, Donald Gilbert, Vasilios K. Kimiskidis, Giacomo Koch, Risto J. Ilmoniemi, Jean Pascal Lefaucheur, Letizia Leocani, Sarah H. Lisanby, Carlo Miniussi, Frank Padberg, Alvaro Pascual-Leone, Walter Paulus, Angel Peterchev, Angelo Quartarone, Alexander Rotenberg, John Rothwell, Paolo M. Rossini, Emiliano Santarnecchi, Mouhsin M. Shafi, Hartwig R. Siebner, Yoshikatzu Ugawa, Eric M. Wassermann, Abraham Zangen, Ulf Ziemann, Mark Hallett
Summary: This article is based on a consensus conference held in Siena, Italy in October 2018, aiming to update safety guidelines for the application of transcranial magnetic stimulation (TMS). New emerging issues discussed include safety concerns with recently developed stimulation devices, novel scenarios of TMS applications, and ethical considerations regarding neuroenhancement.
CLINICAL NEUROPHYSIOLOGY
(2021)
Article
Psychiatry
Leanne M. Williams, John T. Coman, Patrick C. Stetz, Nicole C. Walker, F. Andrew Kozel, Mark S. George, Jong Yoon, Laura M. Hack, Michelle R. Madore, Kelvin O. Lim, Noah S. Philip, Paul E. Holtzheimer
Summary: This study aims to evaluate the relationship between neural targets, cognitive-behavioral performance, and symptom severity, suicidality, and quality of life outcomes in pharmacoresistant depression patients undergoing TMS treatment. The results will help providers select suitable candidates for TMS treatment and predict treatment response more accurately.
Review
Clinical Neurology
Peter J. Fried, Emiliano Santarnecchi, Andrea Antal, David Bartres-Faz, Sven Bestmann, Linda L. Carpenter, Pablo Celnik, Dylan Edwards, Faranak Farzan, Shirley Fecteau, Mark S. George, Bin He, Yun-Hee Kim, Letizia Leocani, Sarah H. Lisanby, Colleen Loo, Bruce Luber, Michael A. Nitsche, Walter Paulus, Simone Rossi, Paolo M. Rossini, John Rothwell, Alexander T. Sack, Gregor Thut, Yoshikazu Ugawa, Ulf Ziemann, Mark Hallett, Alvaro Pascual-Leone
Summary: This article provides recommendations for training practitioners in the safe and effective administration of NIBS techniques, covering three different types of practitioners. It discusses the basic and advanced knowledge and skills that practitioners need to possess, as well as recommendations for curriculum components. The article also encourages licensing and governing bodies to implement these guidelines.
CLINICAL NEUROPHYSIOLOGY
(2021)
Article
Medicine, Research & Experimental
Kevin A. Caulfield, Aprinda Indahlastari, Nicole R. Nissim, James W. Lopez, Holly H. Fleischmann, Adam J. Woods, Mark S. George
Summary: Using reverse-calculation modeling to individualize tDCS doses can reduce electric field variance at the cortex, potentially leading to more effective treatments for working memory.
Letter
Clinical Neurology
Samantha L. Cohen, Marom Bikson, Bashar W. Badran, Mark S. George
Article
Clinical Neurology
Ryan D. Webler, James Fox, Lisa M. McTeague, Philip C. Burton, Logan Dowdle, Edward Baron Short, Jeffrey J. Borckardt, Xingbao Li, Mark S. George, Ziad Nahas
Summary: In this study, the researchers used interleaved TMS-fMRI to manipulate and observe neural activity during high cognitive load conditions. They found that TMS delivered during high cognitive load strengthened cognitive processing and increased activation in FPN nodes and deactivation in DMN nodes. These results suggest that exogenous perturbation of the DLPFC via single pulse TMS can enhance high cognitive demand processing.
Review
Medicine, General & Internal
Claudia A. A. Salazar, Wuwei Feng, Leonardo Bonilha, Steven Kautz, Jens H. H. Jensen, Mark S. S. George, Nathan C. Rowland
Summary: During rehabilitation, transcranial direct current stimulation (tDCS) can be used to prime the motor system of stroke patients and potentially enhance therapy outcomes. However, the efficacy of tDCS varies among patients, which may be influenced by factors such as cortical infarct regions, motor tract injury, and connectivity changes. Neuroimaging techniques are needed to quantify these factors and understand the impact on tDCS delivery. This review summarizes the development of tDCS for stroke from a neuroimaging perspective and discusses potential strategies for personalized tDCS based on anatomy, connectivity, and brain activation dynamics.
JOURNAL OF CLINICAL MEDICINE
(2023)
Editorial Material
Clinical Neurology
Melanie W. Gail, Catrina Sims-Robinson, Heather Boger, Adviye Ergul, Rupak Mukherjee, Dorothea D. Jenkins, Mark S. George