期刊
EXPERT REVIEW OF NEUROTHERAPEUTICS
卷 9, 期 2, 页码 197-210出版社
TAYLOR & FRANCIS LTD
DOI: 10.1586/14737175.9.2.197
关键词
CADASIL; notch3; reactive oxygen species; sirtuin; stroke; vascular dementia; vascular smooth muscle cell
资金
- stroke research network (RENEVAS)
- Vall d'Hebron Research Institute
- Instituto de Salud Carlos III [FI05/00081]
- Ramon Areces Fundation
- RENEVAS
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a rare disease that leads to migraine, mood disorders, recurrent lacunar strokes and early vascular dementia. This autosomal-dominant condition is caused by mutations in the NOTCH3 gene and is characterized by degeneration of vascular smooth muscle cells. At present, no evidence-based treatment for CADASIL is available and only relief of symptoms can be offered to patients. This review focuses on an update of CADASIL management, based on the recent clinical and basic evidence, and discusses possible new treatment targets for CADASIL.
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