Article
Immunology
Ji-Jun Mo, Wei Zhang, Qin-Wen Wen, Ting -Hui Wang, Wen Qin, Zhen Zhang, Hua Huang, Han Cen, Xiu-Di Wu
Summary: The study identified a significant association between the ATG16L1 rs2241880 polymorphism and rheumatoid arthritis (RA) in the Chinese population, as well as a genetic interaction between ATG16L1 and ATG16L2 in determining the development of RA, suggesting the involvement of autophagy in the pathogenesis of RA.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Gastroenterology & Hepatology
Suk Yee Lam, Michiel C. Mommersteeg, Bingting Yu, Linda Broer, Manon C. W. Spaander, Fabian Frost, Stefan Weiss, Henry Voelzke, Markus M. Lerch, Ben Schoettker, Yan Zhang, Hannah Stocker, Hermann Brenner, Daniel Levy, Shih-Jen Hwang, Alexis C. Wood, Stephen S. Rich, Jerome I. Rotter, Kent D. Taylor, Russell P. Tracy, Edmond K. Kabagambe, Marcis Leja, Janis Klovins, Raitis Peculis, Dace Rudzite, Liene Nikitina-Zake, Girts Skenders, Vita Rovite, Andre Uitterlinden, Ernst J. Kuipers, Gwenny M. Fuhler, Georg Homuth, Maikel P. Peppelenbosch
Summary: The association between anti-H pylori IgG titers and the TLR1/6/10 locus was not replicated across different populations, and the variation at this locus affected TLR1-mediated cytokine production and TLR1 surface expression on monocytes and neutrophils.
Article
Agriculture, Dairy & Animal Science
Qixin Guo, Lan Huang, Yong Jiang, Zhixiu Wang, Yulin Bi, Guohong Chen, Hao Bai, Guobin Chang
Summary: Good feed efficiency is crucial for the economic output of the livestock and poultry industries. This study conducted a genome-wide association study to identify potential variants and genes associated with seven feed efficiency measures in ducks. The findings provide insights into the genetic mechanisms and genes involved in feed efficiency-related traits in ducks. Further investigations are warranted to validate these findings.
Article
Medical Laboratory Technology
Leila Jamali, Hossein Sadeghi, Mohammad-Reza Ghasemi, Roohollah Mohseni, Ehsan Nazemalhosseini-Mojarad, Vahid Reza Yassaee, Pegah Larki, Mohammad Reza Zali, Reza Mirfakhraie
Summary: This study evaluated the association between ATG16L1 rs2241880 and ATG5 rs1475270 variants with CRC risk in an Iranian population. The T allele of ATG16L1 rs2241880 was significantly associated with increased CRC risk, while no significant differences were found in ATG5 rs1475270 alleles and genotypes between cases and controls. Further investigations among different populations and ethnicities are needed to refine these conclusions.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2022)
Article
Plant Sciences
Huilong Hong, Mei Li, Yijie Chen, Haorang Wang, Jun Wang, Bingfu Guo, Huawei Gao, Honglei Ren, Ming Yuan, Yingpeng Han, Lijuan Qiu
Summary: This study analyzed the phenotypic diversity and genetic basis of epicotyl length (EL) in soybean using 951 cultivars and landraces from different regions. The study identified 180 QTNs and QEIs associated with EL, and predicted 10 candidate genes that may be involved in seed germination and seedling development.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Immunology
Shou-En Wu, Wei Liang Chen
Summary: The study investigated sarcopenia-related SNPs in Asian older adults and created a genotype score to test the combined effect of these SNPs on sarcopenia risk. Results revealed significant associations between SNPs and sarcopenic indices, with higher genotype scores linked to increased sarcopenia risk.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Veterinary Sciences
Keon Kim, Jung Eun Song, Jae Beom Joo, Hyeon A. Park, Chang Hyeon Choi, Chang Yun Je, Ock Kyu Kim, Sin Wook Park, Yoon Jung Do, Tai-Young Hur, Sang-Ik Park, Chang-Min Lee
Summary: This study conducted a GWAS analysis to investigate the genetic predisposition to mammary gland tumors (MGT) in Maltese dogs. Several significant SNPs associated with MGT phenotype were identified, providing a basis for further research on the genetic predisposition to MGTs in Maltese dogs.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Plant Sciences
Narayana Bhat Devate, Hari Krishna, Sunil Kumar V. Parmeshwarappa, Karthik Kumar Manjunath, Divya Chauhan, Shweta Singh, Jang Bahadur Singh, Monu Kumar, Ravindra Patil, Hanif Khan, Neelu Jain, Gyanendra Pratap Singh, Pradeep Kumar Singh
Summary: This study conducted a genome-wide association study to identify markers associated with traits under heat and drought stress in bread wheat. The results provide valuable markers that can be used for marker-assisted breeding to develop climate-resilient cultivars.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Medicine, General & Internal
Changqing Ma, Chad E. Storer, Uma Chandran, William A. LaFramboise, Patricia Petrosko, Madison Frank, Douglas J. Hartman, Liron Pantanowitz, Talin Haritunians, Richard D. Head, Ta-Chiang Liu
Summary: Individuals with the ATG16L1 T300A genotype in gastric carcinoma show suppressed EGFR and PPAR pathways, increased tumor apoptosis, and improved overall survival. Genotyping gastric cancer patients may offer additional insights for clinical stratification.
Article
Fisheries
W. K. M. Omeka, D. S. Liyanage, Sukkyoung Lee, Chaehyeon Lim, Hyerim Yang, W. M. Gayashani Sandamalika, H. M. V. Udayantha, Gaeun Kim, Subothini Ganeshalingam, Taehyug Jeong, Seong-Rip Oh, Seung-Hwan Won, Hyoung-Bum Koh, Mun-Kwan Kim, David B. Jones, Cecile Massault, Dean R. Jerry, Jehee Lee
Summary: Traits linked to growth performance in farmed fish are important for profitability in aquaculture. A genome-wide association study (GWAS) on olive flounder identified several single nucleotide polymorphisms (SNPs) associated with growth traits. These findings contribute to understanding the molecular basis of growth regulation and promote the use of SNP-based genomic selection in flounder culture.
Article
Dentistry, Oral Surgery & Medicine
Liwen Fan, Lan Ma, Guirong Zhu, Siyue Yao, Xiaofeng Li, Xin Yu, Yongchu Pan, Lin Wang
Summary: Our GWAS study identified chromosome 2 variants, including rs147680216, as well as three novel susceptibility loci, associated with the risk of premolar agenesis in the Chinese population.
Article
Agriculture, Dairy & Animal Science
Bowen Gu, Ruifan Sun, Xingqiang Fang, Jipan Zhang, Zhongquan Zhao, Deli Huang, Yuanping Zhao, Yongju Zhao
Summary: This study conducted a genome-wide association study on a Chinese indigenous goat breed, Dazu black goats, to identify the genetic variants associated with body conformation traits. A total of 53 significant single nucleotide polymorphisms and 42 candidate genes were detected. These findings have practical applications for genetic improvement and economic benefits in the goat meat industry.
Article
Biotechnology & Applied Microbiology
Charlotte E. Vollenbrock, Delnaz Roshandel, Melanie M. van der Klauw, Bruce H. R. Wolffenbuttel, Andrew D. Paterson
Summary: This study found that skin autofluorescence (SAF) has a high heritability and identified genetic variants associated with SAF through genome-wide association studies (GWAS). Further investigating the genetic architecture of SAF can improve its utility as a tool for screening and early detection of diseases.
Article
Medicine, General & Internal
Hyun-Ju An, Jae-Hwa Kim, Siyeong Yoon, Junwon Choi, Jeongmo Koo, Soonchul Lee
Summary: This study aimed to identify specific genes or genetic variants associated with rotator cuff tears through a genome-wide association study. More than 20 significantly associated SNPs were found. However, the study was limited by the small sample size and requires further validation. Nevertheless, the identification of potential genetic variants related to rotator cuff injury would aid in the early detection of individuals at risk and provide insight into future gene therapies.
Article
Medicine, Research & Experimental
Ching-Lung Ko, Wei-Zhi Lin, Meng-Ting Lee, Yu-Tien Chang, Hung-Che Lin, Yi-Syuan Wu, Jun-Fu Lin, Ke-Ting Pan, Yu-Chuan Chang, Ko-Han Lee, Yi-Lun Lee, Tsung-Ting Hsieh, Jia-Hsin Huang, Chih-Hung Wang, Sung-Sen Yang, Hsiang-Cheng Chen, Chi-Ming Chu
Summary: This study explored the race-specific SNP susceptibility of AS in Taiwanese individuals and found an association between HLA-B27 and AS susceptibility SNPs. The study also found differences in AS SNPs between Taiwanese individuals and other races, and that Taiwanese individuals with HLA-B27 positivity had a higher proportion of minor alleles. Additionally, AS polygenic risk score models were developed and individuals with high polygenic risk had a fivefold increased risk of developing AS.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)