期刊
EXPERT REVIEW OF CLINICAL IMMUNOLOGY
卷 10, 期 3, 页码 353-362出版社
TAYLOR & FRANCIS LTD
DOI: 10.1586/1744666X.2014.882232
关键词
immune regulation; intestine; mucosal immunity; Treg; Th17
类别
资金
- National Basic Research Program of China [2010CB945301, 2011CB710903]
- National Natural Science Foundation for General and Key Programs [81000189, C81130055, C81072396]
- Knowledge Innovation Program of Chinese Academy of Sciences [XDA04020202-19]
Balanced mucosal immunity in the gut is critical for host homeostasis and defense. Th17 cells are a subset of IL-17-producing CD4(+) T cells, which play a crucial role in clearing pathogens during host defense reactions and in inducing tissue inflammation in autoimmune diseases. CD4(+)CD25(+) Foxp3(+) regulatory T cells (Tregs) are recognized as one of the major regulatory factors in immune tolerance and inflammatory responses. Since both Tregs and Th17 cells pertain to the gut immune system, their inter-regulation and balance represent a novel mechanism for maintaining the intestinal immune and inflammatory homeostasis. Accordingly, the imbalance and dysregulation of Tregs and Th17 cells in the intestine is closely associated with intestinal autoimmune disorders like the inflammatory bowel diseases. In this review, we discuss the characteristics of gut Tregs and Th17 cells and their role in gut diseases.
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