Review
Genetics & Heredity
Jaehyeok Roh, Subbaya Subramanian, Neal J. Weinreb, Reena Kartha
Summary: Gaucher disease is a common lysosomal storage disease caused by gene mutations, which results in various pathological changes and associated complications such as skeletal manifestations and Parkinson's disease. This article provides an overview of lysosomal storage diseases, analyzes the factors contributing to oxidative stress and inflammation in the pathophysiology of Gaucher disease, discusses the current established treatments as well as potential treatment options targeting these factors.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2022)
Article
Gastroenterology & Hepatology
Asa H. Everhov, Gustaf Bruze, Jonas Soderling, Johan Askling, Jonas Halfvarson, Karin Westberg, Petter Malmborg, Caroline Nordenvall, Jonas F. Ludvigsson, Ola Olen
Summary: The study in Sweden found that patients with IBD had 5% lower earnings than siblings from the year of diagnosis and at least 5 years onwards, mainly explained by differences between women with IBD and their sisters. However, there were no differences in disposable income between patients and siblings during the investigated time period.
JOURNAL OF CROHNS & COLITIS
(2021)
Editorial Material
Biochemistry & Molecular Biology
Richard Huskey
Summary: Gossip is more than just trash talk, it can influence behavior, foster cooperation, and increase group affiliation.
Article
Biochemistry & Molecular Biology
Guillermo H. Jimenez Aleman, Venkatesh P. Thirumalaikumar, Georg Jander, Alisdair R. Fernie, Aleksandra Skirycz
Summary: The oxylipin 12-oxo-phytodienoic acid (OPDA) is a biosynthetic precursor of the plant hormone jasmonic acid, but also functions as a signaling molecule independent of jasmonates. OPDA is involved in various biological processes across plant species, including defense and stress responses, growth regulation, and development. This article summarizes what is known about OPDA metabolism and signaling, discussing its jasmonate dependent and independent roles, as well as open questions regarding the OPDA protein interactome and biological roles of OPDA conjugates.
Editorial Material
Hematology
Bethany T. Samuelson Bannow
Summary: In the largest meta-analysis to date on the topic, Valeriani et al identified 4 clear benefits of using anticoagulation to treat splanchnic vein thrombosis (SVT), including increased recanalization, decreased thrombosis progression, decreased major bleeding, and decreased mortality.
Review
Cell Biology
Tautvydas Paskevicius, Rabih Abou Farraj, Marek Michalak, Luis B. Agellon
Summary: Calnexin is an integral ER membrane protein with distinct domains in the ER lumen and cytosol. It acts as a chaperone for folding and quality control of proteins, similar to calreticulin. Recent studies have shown that the cytosolic domain of calnexin undergoes post-translational modifications and interacts with various proteins, suggesting its role in coordinating ER functions with cytosolic events.
Review
Biochemistry & Molecular Biology
Yu-Hsuan Lee, Daan Ren, Byungsun Jeon, Hung-wen Liu
Summary: This review summarizes recent advances in the study of S-adenosyl-l-methionine (SAM) utilizing enzymes. SAM is a naturally occurring molecule that is commonly associated with methyltransfer reactions. However, it has been found that SAM can also donate other moieties during natural product biosynthetic reactions. The review focuses on the discovery of novel SAM utilizing enzymes and the role of SAM in sulfonium chemistry.
NATURAL PRODUCT REPORTS
(2023)
Review
Endocrinology & Metabolism
Hannah A. Taylor, Lena Przemylska, Eva M. Clavane, Paul J. Meakin
Summary: This review focuses on the research of beta-site amyloid precursor protein cleaving enzyme-1 (BACE1) and its role in metabolic diseases. It discusses the regulation of BACE1, its effect on metabolism, and the possibility of using BACE1 inhibitors as a treatment for obesity and its comorbidities. The study finds that BACE1 is expressed not only in the brain but also in various cell types, and its dysregulation is implicated in the development of metabolic diseases. Additionally, BACE1 knockout models and clinical trials of BACE1 inhibitors suggest a physiological role of BACE1 in energy metabolism and weight regulation.
Review
Immunology
Yuanxin Chen, Zhijie Huang, Zhengming Tang, Yisheng Huang, Mingshu Huang, Hongyu Liu, Dirk Ziebolz, Gerhard Schmalz, Bo Jia, Jianjiang Zhao
Summary: Fusobacterium nucleatum is a common oral opportunistic bacterium associated with periodontal diseases, halitosis, dental pulp infection, oral cancer, and systemic diseases. This study evaluated the progress in research on epidemiological evidence, pathogenic mechanisms, and treatment methods related to F. nucleatum in oral and systemic diseases.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Editorial Material
Biochemistry & Molecular Biology
Sarah Mundt, Annika Keller, Melanie Greter
Summary: Recent research has found an active neuroimmune exchange at brain border regions, challenging the concept of the immune-privileged central nervous system; dural sinuses serve as a conduit for brain-derived antigens to interact with the immune system, allowing in situ immune surveillance.
Review
Medicine, General & Internal
Hong-Xing Li, Cui Zhang, Kai Zhang, Yi-Zhe Liu, Xiao-Xiao Peng, Qiang Zong
Summary: A meta-analysis was conducted to investigate the relationship between inflammatory bowel disease (IBD) and Parkinson's Disease (PD) risk. The results showed that patients with IBD have a moderately increased risk of PD, especially those aged 60 years or older.
FRONTIERS IN MEDICINE
(2023)
Article
Rheumatology
Aleksandra Halina Opinc, Joanna Samanta Makowska
Summary: Antisynthetase syndrome (ASS) is a heterogeneous disease with diverse clinical manifestations, requiring treatment based on glucocorticosteroids and immunosuppressive agents. Current classification criteria may not fully correspond with the clinical patterns of the disease.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2021)
Article
Immunology
Isabel Garrido, Susana Lopes, Manuel Sobrinho Simoes, Rodrigo Liberal, Joanne Lopes, Fatima Carneiro, Guilherme Macedo
Summary: The case of acute severe autoimmune hepatitis following COVID-19 vaccination highlights the importance of closely monitoring adverse reactions during the vaccination process to ensure safety. Healthcare providers must remain vigilant during mass COVID-19 vaccination to detect and manage potential complications promptly.
JOURNAL OF AUTOIMMUNITY
(2021)
Review
Biochemistry & Molecular Biology
Bilal Alashkar Alhamwe, Daniel P. Potaczek, Sarah Miethe, Fahd Alhamdan, Lukas Hintz, Arslan Magomedov, Holger Garn
Summary: Extracellular vesicles play a crucial role in asthma, influencing disease mechanisms and potential therapeutic interventions. EVs also show great potential in the diagnosis of asthma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Editorial Material
Biochemistry & Molecular Biology
Vanessa J. Flegler, Tim Rasmussen, Bettina Boettcher
Summary: The bacterial mechanosensitive channel of small conductance (MscS) enters a desensitized state when it loses all coordinated lipids under membrane tension, as visualized in a recent study by Zhang et al.
TRENDS IN BIOCHEMICAL SCIENCES
(2021)
