Article
Urology & Nephrology
Christian Morath, Matthias Schaier, Eman Ibrahim, Lei Wang, Christian Kleist, Gerhard Opelz, Caner Suesal, Gerald Ponath, Mostafa Aly, Cristiam M. Alvarez, Florian Kaelble, Claudius Speer, Louise Benning, Christian Nusshag, Luiza Pego da Silva, Claudia Sommerer, Angela Hueckelhoven-Krauss, David Czock, Arianeb Mehrabi, Constantin Schwab, Ruediger Waldherr, Paul Schnitzler, Uta Merle, Thuong Hien Tran, Sabine Scherer, Georg A. Boehmig, Carsten Mueller-Tidow, Jochen Reiser, Martin Zeier, Michael Schmitt, Peter Terness, Anita Schmitt, Volker Daniel
Summary: This study shows that using donor-derived modified immune cells (MICs)-PBMCs for specific immunosuppression treatment before kidney transplantation can result in an increase in CD19(+)CD24(hi)CD38(hi) transitional B lymphocytes by up to 68-fold compared to transplanted controls.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Review
Cell Biology
Weixiong Zheng, Lingxiang Yang, Shiming Jiang, Mingxiang Chen, Jinzheng Li, Zuojing Liu, Zhongjun Wu, Jianping Gong, Yong Chen
Summary: Liver transplantation is a effective treatment for end-stage liver disease and significantly prolongs the survival time of patients, but acute and chronic rejection still remain major obstacles. Investigating induced immune tolerance is of crucial theoretical significance and socio-economic value. This paper comprehensively summarizes the important roles of Kupffer cells in establishing immune tolerance after transplantation, including phagocytosis, cell polarization, antigen presentation, and cell membrane proteins, providing a theoretical basis for further study and clinical application of Kupffer cells in liver transplantation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Immunology
Hongfeng Huang, Qixia Shen, Jingyi Zhou, Xiuyan Yang, Qiuqin Cai, Jia Shen, Shi Feng, Wenqing Xie, Hong Jiang, Jianghua Chen
Summary: The clinical experience demonstrates the efficacy of non-myeloablative conditioning protocol in inducing tolerance in HLA identical patients, and complete chimerism may be a risk factor for GVHD.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Michelle F. Huffaker, Srinath Sanda, Sindhu Chandran, Sharon A. Chung, E. William St Clair, Gerald T. Nepom, Dawn E. Smilek
Summary: The article reviews concepts evolved from the clinical trial experience of the Immune Tolerance Network, focusing on lessons learned from innovative mechanistic studies and new strategies for tolerance induction.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Urology & Nephrology
David Wojciechowski, Alexander Wiseman
Summary: The long-term management of maintenance immunosuppression in kidney transplant recipients is complex, with various drug regimens having their own advantages and disadvantages. Balancing between treatment efficacy and adverse effects is crucial in decision-making for these patients.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Article
Cell Biology
Maria Florencia Tellechea, Flavia S. Donaires, Vinicius S. de Carvalho, Barbara A. Santana, Fernanda B. da Silva, Raissa S. Tristao, Lilian F. Moreira, Aline F. de Souza, Yordanka M. Armenteros, Lygia Pereira, Rodrigo T. Calado
Summary: This study used iPSCs to model immune aplastic anemia and found that the differentiation potential of hematopoietic cells in this disease is significantly reduced, suggesting that specific epigenetic changes in HSPCs caused by immune attack may limit cell proliferation and differentiation.
CELL DEATH & DISEASE
(2022)
Article
Immunology
Shuyao Qiu, Xiangqian Luo, Lihua Mo, Shuang Zhang, Yun Liao, Li Guan, Liteng Yang, Qinmiao Huang, Dabo Liu, Pingchang Yang
Summary: This study aims to enhance the therapeutic efficacy of allergen-specific immunotherapy (AIT) in experimental allergic rhinitis (AR) by using TAFA4 as an adjuvant. The results show that TAFA4 activates dendritic cells (DCs) in the airway tissues and induces the expression of IL-10, which attenuates the allergic response in mice.
Article
Cell & Tissue Engineering
Xiao-Yan Huang, Zhan-Kui Jin, Meng Dou, Bing-Xuan Zheng, Xiang-Rong Zhao, Qing Feng, Yang-Meng Feng, Xiang-Long Duan, Pu-Xun Tian, Cui-Xiang Xu
Summary: This study explored the potential of SN-iPSCs-imDCs for inducing immunotolerance in vitro and in vivo following organ transplantation.
WORLD JOURNAL OF STEM CELLS
(2022)
Review
Medicine, General & Internal
Naoya Sato, Shigeru Marubashi
Summary: Allogeneic islet transplantation is an effective treatment for Type 1 diabetes, but chronic rejection remains a challenge for long-term engraftment. Breakthroughs in tolerance induction using ADLs show great potential, but obstacles such as islet immunogenicity and instant blood-mediated response need to be addressed in the future.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Immunology
Jingyu Jiang, Haitao Huang, Ruihan Chen, Yimou Lin, Qi Ling
Summary: Hepatocellular carcinoma is a major cause of cancer-related death globally, and liver transplantation is the best treatment option. However, HCC recurrence after transplantation remains a challenge. Immune checkpoint inhibitors have revolutionized cancer treatment and offer a new strategy for HCC recurrence after transplantation. This review summarizes the use of immunotherapy for post-transplant HCC recurrence and evaluates its efficacy and safety.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Ji Lei, Maria M. Coronel, Esma S. Yolcu, Hongping Deng, Orlando Grimany-Nuno, Michael D. Hunckler, Vahap Ulker, Zhihong Yang, Kang M. Lee, Alexander Zhang, Hao Luo, Cole W. Peters, Zhongliang Zou, Tao Chen, Zhenjuan Wang, Colleen S. McCoy, Ivy A. Rosales, James F. Markmann, Haval Shirwan, Andres J. Garcia
Summary: We report a strategy of cotransplanting allogeneic islets and streptavidin (SA)-FasL-presenting microgels to the omentum under transient rapamycin monotherapy, which resulted in robust glycemic control, sustained C-peptide levels, and graft survival in diabetic nonhuman primates. This localized immunomodulatory strategy shows translational potential in beta cell replacement for treating type 1 diabetes.
Review
Biotechnology & Applied Microbiology
Guojiao Lin, Jialiang Wang, Yong-Guang Yang, Yuning Zhang, Tianmeng Sun
Summary: This paper reviews the research progress on how nano-delivery systems can be modulated for targeted delivery to dendritic cells and induce immune tolerance.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Filip Cvetkovski, J. Mark Hexham, Erik Berglund
Summary: Liver transplant recipients require lifelong immunosuppression therapy to preserve allograft function, which may lead to increased risks of malignancy, infection, renal impairment, and other toxicities. Although rare cases may achieve operational tolerance, predicting successful withdrawal of immunosuppression is difficult and requires long-term study.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Surgery
Katrin Peckert-Maier, Alfrun Schoenberg, Andreas B. Wild, Dmytro Royzman, Gabriele Braun, Lena Stich, Karina Hadrian, Philipp Tripal, Claus Cursiefen, Alexander Steinkasserer, Elisabeth Zinser, Felix Bock
Summary: The use of the immune modulator soluble CD83 (sCD83) to pre-incubate donor tissue significantly improves graft survival in a high-risk corneal transplantation model by modulating recipient M phi and DCs towards tolerance and establishing a tolerogenic microenvironment. This functional strategy opens up new therapeutic options in transplantation.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Review
Cell Biology
Xiaodong Du, Mingqian Li, Chen Huan, Guoyue Lv
Summary: This review discusses the origin, maturation, migration, and pathological effects of dendritic cell subsets in liver transplantation, as well as their roles in transplant rejection and tolerance. The latest progress in dendritic cell-based treatment regimens is also outlined.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Immunology
Annemarie Weissenbacher, Christina Bogensperger, Rupert Oberhuber, Andras Meszaros, Silvia Gasteiger, Hanno UlmkavyaBer, Valeria Berchtold, Felix J. Krendl, Margot Fodor, Franka Messner, Theresa Hautz, Giorgi Otarashvili, Thomas Resch, Christian Margreiter, Manuel Maglione, Christian Irsara, Andrea Griesmacher, Marc Raynaud, Robert Breitkopf, Jakob Troppmair, Dietmar Ofner, Benno Cardini, Stefan Schneeberger
Summary: This study found that perfusate parameters during normothermic machine perfusion (NMP) can predict early allograft dysfunction (EAD) after liver transplantation. Aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase, alkaline phosphatase, and sodium levels in the perfusate were correlated with EAD. Additionally, the number of perfusate platelets and von Willebrand Factor antigen were also important indicators for EAD occurrence. Lower perfusate pH was associated with a higher risk of EAD.
Article
Engineering, Biomedical
Annemarie Weissenbacher, Franka Messner, Silvia Gasteiger, Afschin Soleiman, Dietmar Oefner, Stefan Schneeberger
Article
Medicine, General & Internal
Nora Jahn, Maria Theresa Voelker, Sven Laudi, Sebastian Stehr, Stefan Schneeberger, Gerald Brandacher, Elisabeth Sucher, Sebastian Rademacher, Daniel Seehofer, Robert Sucher, Hans Michael Hau
Summary: The combination of peak lipase and CRP levels is highly effective in predicting early pancreatic graft dysfunction following simultaneous pancreas-kidney transplantation. However, this parameter has less predictive value for early renal graft dysfunction.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cell Biology
Yinan Guo, Franka Messner, Sarah E. Beck, Marcos Iglesias Lozano, Hubert Schwelberger, Yichuan Zhang, Kai Kammers, Byoung Chol Oh, Elizabeth D. Greene, Gerald Brandacher, Kelvin G. M. Brockbank
Summary: This study compared the preservative capacity of gluconate-lactobionate-dextran (Unisol) solutions and histidine-tryptophan-ketoglutarate (HTK) solution. The results showed that Unisol-based solutions demonstrated faster rebeating time and better contractility after cardiac transplantation compared to HTK. The expression of proinflammatory markers was also reduced in Unisol-treated animals.
Article
Medicine, General & Internal
Nora Jahn, Maria Theresa Voelker, Sven Laudi, Sebastian Stehr, Stefan Schneeberger, Gerald Brandacher, Elisabeth Sucher, Sebastian Rademacher, Daniel Seehofer, Hans Michael Hau, Robert Sucher
Summary: This study investigated the effects of different volatile anesthetics on early ischemia-reperfusion injury (IRI)-associated clinical outcomes in pancreas transplantation recipients. The results showed that the use of sevoflurane and desflurane was associated with increased early graft survival and decreased IRI-related postoperative complications.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Casie A. A. Pendexter, Omar Haque, Mohammadreza Mojoudi, Sarah Maggipinto, Marion Goutard, Simona Baicu, Alexandre G. G. Lellouch, James F. F. Markmann, Gerald Brandacher, Heidi Yeh, Shannon N. N. Tessier, Curtis Cetrulo, Korkut Uygun
Summary: Vascularized composite allografts (VCAs) are transplants of heterogenous tissue used to restore form and function after amputation or tissue loss. Rat limb VCA models have been used to study the pathophysiology of these transplants, but have mainly focused on hindlimb VCAs which do not anatomically translate to upper extremity transplantation. This study optimizes rat forelimb VCA procurement and sub-normothermic machine perfusion (SNMP) protocols, providing useful information for future upper extremity VCA preservation studies.
Article
Medicine, General & Internal
Sebastian Sallaberger, Lukas Buchwinkler, Susanne Eder, Stefan Schneeberger, Gert Mayer, Markus Pirklbauer
Summary: Kidney transplantation is the preferred method for treating kidney failure, but there is still a significant proportion of graft losses. This study provides information on kidney graft and patient survival rates, eGFR trajectories, and rejection rates, and also establishes a valuable biobank for the future discovery and validation of prognostic methods.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Julia Hofmann, Marlene Puehringer, Sabrina Steinkellner, Aline-Sophie Holl, Andras T. Meszaros, Stefan Schneeberger, Jakob Troppmair, Theresa Hautz
Summary: The implementation of ex vivo organ machine perfusion (MP) has increased the donor pool by enabling organ assessment and potential regeneration and treatment of marginal organs. While whole organ research is costly, in vitro models such as tissue slice cultures and organoids are more suitable for early stage research or studying specific disease mechanisms. This review discusses the role of oxidative stress during ex vivo MP and the suitability of different in vitro models for studying underlying mechanisms and testing treatment strategies.
Article
Pediatrics
Anna M. Kavallar, Franka Messner, Stefan Scheidl, Rupert Oberhuber, Stefan Schneeberger, Denise Aldrian, Valeria Berchtold, Murat Sanal, Andreas Entenmann, Simon Straub, Anna Gasser, Andreas R. Janecke, Thomas Mueller, Georg F. Vogel
Summary: This case report presents three cases of PFIC1 patients who underwent LT and successfully resolved graft inflammation and steatosis by using terminal ileum SBD.
Article
Biochemistry & Molecular Biology
Julia Hofmann, Andras T. Meszaros, Madita L. Buch, Florian Nardin, Verena Hackl, Carola J. Strolz, Bettina Zelger, Margot Fodor, Benno Cardini, Rupert Oberhuber, Thomas Resch, Annemarie Weissenbacher, Jakob Troppmair, Stefan Schneeberger, Theresa Hautz
Summary: The majority of liver transplantation organs come from brain-dead donors, but there is an increasing consideration for donation after circulatory death (DCD) organs to overcome the shortage. Normothermic machine perfusion (NMP) can restore metabolic activity and assess organ quality and function. In comparing DCD and brain-dead donors (DBD) livers during NMP, DCD livers initially showed greater impairment of mitochondrial function, but eventually recovered and performed similarly to DBD livers. Cytokine analysis showed elevated levels in DCD livers towards the end of NMP. This study suggests the potential for using more DCD organs for transplantation, but donor organ quality criteria should be developed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Ruben Bellotti, Benno Cardini, Carola J. Strolz, Stefan Staettner, Rupert Oberhuber, Eva Braunwarth, Thomas Resch, Stefan Scheidl, Christian Margreiter, Stefan Schneeberger, Dietmar Ofner, Manuel Maglione
Summary: This study compared three different reconstruction techniques for pancreaticoduodenectomy, and found that they did not significantly affect the rates of postoperative complications. However, pancreatogastrostomy had a higher incidence of post-pancreatectomy hemorrhage, indicating the need for meticulous hemostasis during the surgery.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biotechnology & Applied Microbiology
John R. Aggas, Sara Abasi, Carolyn Ton, Sara Salehi, Renee Liu, Gerald Brandacher, Warren L. Grayson, Anthony Guiseppi-Elie
Summary: Vascularized composite allotransplantation is widely used for injuries to complex anatomical structures. Prolonged cold storage damages grafts and limits their viability. Tissue ischemia is a major concern and can lead to poor transplantation outcomes. This perspective introduces MMBIS as a noninvasive monitoring technique to assess graft preservation efficacy and viability in real-time. Developing MMBIS and incorporating AI can improve transplantation outcomes by stratifying allografts.
BIOENGINEERING-BASEL
(2023)
Review
Medicine, Research & Experimental
Carolyn Ton, Sara Salehi, Sara Abasi, John R. Aggas, Renee Liu, Gerald Brandacher, Anthony Guiseppi-Elie, Warren L. Grayson
Summary: Vascularized composite allotransplantation plays a crucial role in improving quality of life and restoring functionality. However, the complex tissue composition of VCAs presents unique clinical challenges, increasing the risk of transplant rejection. The development of methods to evaluate VCAs is crucial for mitigating rejection.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Katharina Esswein, Marco Volpi, Marijana Ninkovic, Veronika Kroepfl, Elisabeth Gasser, Andreas Lorenz, Lea Stecher, Reinhold Kafka-Ritsch, Stefan Schneeberger, Dietmar Oefner, Alexander Perathoner
Summary: This study aimed to analyze the adherence to intensive follow-up and the risk of recurrence in patients with colon cancer in UICC stages I and II. The results showed that the risk of recurrence was low in early tumor stages, suggesting that a less intensive follow-up protocol is reasonable for these patients.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2023)
Article
Oncology
Felix J. Krendl, Franka Messner, Gregor Laimer, Angela Djanani, Andreas Seeber, Georg Oberhuber, Dietmar Oefner, Dominik Wolf, Stefan Schneeberger, Reto Bale, Christian Margreiter
Summary: This study presents the experience in managing liver metastases from intracranial SFTs/HPCs. The results suggest that a multimodal treatment concept, including surgery, loco-regional and systemic therapies, can achieve long-term survival.
