Article
Cardiac & Cardiovascular Systems
Eva Querdel, Marina Reinsch, Liesa Castro, Deniz Kose, Andrea Bahr, Svenja Reich, Birgit Geertz, Barbel Ulmer, Mirja Schulze, Marc D. Lemoine, Tobias Krause, Marta Lemme, Jascha Sani, Aya Shibamiya, Tim Stuedemann, Maria Koehne, Constantin von Bibra, Nadja Hornaschewitz, Simon Pecha, Yusuf Nejahsie, Ingra Mannhardt, Torsten Christ, Hermann Reichenspurner, Arne Hansen, Nikolai Klymiuk, M. Krane, C. Kupatt, Thomas Eschenhagen, Florian Weinberger
Summary: The transplantation of engineered heart tissue (EHT) patches resulted in partial remuscularization of the injured heart and improved left ventricular function in a dose-dependent manner in guinea pig and pig models. Human-scale patches were successfully transplanted onto pigs in a proof-of-principle study.
Article
Cardiac & Cardiovascular Systems
Tim Stuedemann, Judith Roessinger, Christoph Manthey, Birgit Geertz, Rajiven Srikantharajah, Constantin von Bibra, Aya Shibamiya, Maria Koehne, Antonius Wiehler, J. Simon Wiegert, Thomas Eschenhagen, Florian Weinberger
Summary: This study reveals the mechanism of how transplanted cardiomyocytes actively contribute to heart function, supporting the hypothesis that the delivery of new force-generating myocardium can serve as a regenerative therapeutic strategy.
Review
Cardiac & Cardiovascular Systems
Luciana Da Silveira Cavalcante, Shannon N. Tessier
Summary: Heart transplantation emerged as a life-saving option for patients with end-stage heart failure in the late 1960s. While traditional cold storage methods offer only short-term heart preservation, new technologies aim at extending ex vivo lifespan. Limited research tools pose a barrier for experimental efforts, with smaller vertebrate models like zebrafish potentially filling critical gaps in research.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2021)
Article
Endocrinology & Metabolism
Hiroo Sasaki, Hidetaka Suga, Kazuhito Takeuchi, Yuichi Nagata, Hideyuki Harada, Tatsuma Kondo, Eiji Ito, Sachi Maeda, Mayu Sakakibara, Mika Soen, Tsutomu Miwata, Tomoyoshi Asano, Hajime Ozaki, Shiori Taga, Atsushi Kuwahara, Tokushige Nakano, Hiroshi Arima, Ryuta Saito
Summary: We have successfully developed pituitary organoids (POs) derived from human embryonic stem cells (hESC). Transplantation of these POs into hypopituitary severe combined immunodeficient (SCID) mice was able to effectively restore ACTH secretion, thus providing a potential treatment for hypopituitarism.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Cell Biology
Raheleh Farahzadi, Behnaz Valipour, Soheila Montazersaheb, Ezzatollah Fathi
Summary: Adult stem cells (ASCs) throughout the body can support tissue growth and repair. The function of stem cells is influenced by signals derived from their specific microenvironment or niche. Studies have shown that aging of the niche can lead to a decline in stem cell function and is associated with aging and age-related disorders.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Medicine, General & Internal
Ximo Garcia-Dominguez, Cesar D. Vera-Donoso, Eric Lopez-Moncholi, Victoria Moreno-Manzano, Jose S. Vicente, Francisco Marco-Jimenez
Summary: By embedding sildenafil citrate into a metanephroi transplantation, further growth post-transplantation can be achieved, leading to a functional kidney graft on demand. The study demonstrates that sildenafil citrate can increase the weight of the new kidneys, maintain tubule integrity and endocrine functionality, and ensure excretory function.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cell & Tissue Engineering
Edina Sehic, Emy Thoren, Ingigerdur Gudmundsdottir, Mihai Oltean, Mats Brannstrom, Mats Hellstrom
Summary: This study investigated the immune response to decellularized tissue transplantation with MSCs recellularized scaffolds. The results showed that MSCs created a favorable microenvironment by increasing anti-inflammatory factors, promoting the population of immune regulatory cells and anti-inflammatory macrophages, and reducing the cytotoxic T cell population.
JOURNAL OF TISSUE ENGINEERING
(2022)
Review
Cell Biology
Taketaro Sadahiro, Masaki Ieda
Summary: Cardiovascular diseases are a leading cause of death worldwide. Direct reprogramming that converts cardiac fibroblasts into cardiomyocytes offers a promising approach for cardiac regeneration.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2022)
Article
Emergency Medicine
Courtney Premer, Ivonne H. Schulman, Jennifer S. Jackson
Summary: MSCs show promising potential in treating acute diseases, with clinical trials demonstrating safety but inconsistent efficacy data, necessitating further research.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Izeia Lukin, Itsasne Erezuma, Lidia Maeso, Jon Zarate, Martin Federico Desimone, Taleb H. Al-Tel, Alireza Dolatshahi-Pirouz, Gorka Orive
Summary: Tissue engineering has become a viable medical alternative in response to the increasing lifespan of society. This review focuses on gelatin, a widely used biomaterial in tissue engineering, and discusses ongoing concerns and the latest developments in this field. Advancements in technology, such as 3D bioprinting and gelatin functionalization, have allowed for better replication of native tissue in gelatin-based systems. This breakthrough has implications for both the manufacturing process, making it more practical and cost-effective, and the future use of gelatin in disease detection and diagnosis rather than treatment.
Review
Biochemistry & Molecular Biology
Olga Kuten Pella, Istvan Hornyak, Denes Horvathy, Eszter Fodor, Stefan Nehrer, Zsombor Lacza
Summary: This review summarizes the advanced therapeutic uses of albumin in regenerative medicine, highlighting novel compositions that leverage the excellent regenerative potential of this protein. Albumin coating enhances the biocompatibility of various implants and promotes stem cell adhesion and proliferation. The anticoagulant, antimicrobial, and anti-inflammatory properties of albumin allow precise control of the biological response to tissue-engineering constructs. Combining albumin with natural or synthetic materials also enables the development of composites for cardiac, neural, hard and soft tissue engineering.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Materials Science, Paper & Wood
Walid Kamal Abdelbasset, Saud M. Alrawaili, Ahmed M. Osailan, Ahmed Abdelmoniem Ibrahim, Gaber S. Soliman, Ahmed M. Abodonya
Summary: Valvular heart disease presents a clinical challenge, and heart valve tissue engineering offers potential solutions. Polysaccharides as scaffolding biomaterials have widespread applications in HVTE.
Article
Multidisciplinary Sciences
David R. Maestas, Liam Chung, Jin Han, Xiaokun Wang, Sven D. Sommerfeld, Sean H. Kelly, Erika Moore, Helen Hieu Nguyen, Joscelyn C. Mejias, Alexis N. Pena, Hong Zhang, Joshua S. T. Hooks, Alexander F. Chin, James I. Andorko, Cynthia A. Berlinicke, Kavita Krishnan, Younghwan Choi, Amy E. Anderson, Ronak Mahatme, Christopher Mejia, Marie Eric, JiWon Woo, Sudipto Ganguly, Donald J. Zack, Liang Zhao, Edward J. Pearce, Franck Housseau, Drew M. Pardoll, Jennifer H. Elisseeff
Summary: The immune system plays an important role in tissue repair. A regenerative immunotherapy using the helminth Schistosoma mansoni soluble egg antigen (SEA) was developed, which stimulates the production of IL-4 and other type 2-associated cytokines. The application of regenerative SEA (rSEA) promotes accumulation of IL-4-expressing T helper cells, eosinophils, and regulatory T cells, leading to improved repair and reduced fibrosis. Encapsulation and controlled release of rSEA in a hydrogel further enhance tissue repair.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Biochemistry & Molecular Biology
Kamini Kaushal, Apoorvi Tyagi, Janardhan Keshav Karapurkar, Eun-Jung Kim, Parthasaradhireddy Tanguturi, Kye-Seong Kim, Han-Sung Jung, Suresh Ramakrishna
Summary: The study demonstrates that ubiquitin-specific protease 11 (USP11) is a key regulator of MSX1 protein in osteogenic differentiation. USP11 interacts with MSX1 and prevents its degradation through deubiquitinating activity, enhancing the differentiation potential of human mesenchymal stem cells. These findings suggest USP11 as a potential target for bone regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Materials Science, Multidisciplinary
Xiangyu Dong, Shuxiang Zhang, Yi Xu, Longquan Chen, Qiang Wei, Changsheng Zhao
Summary: A simple and smart method has been developed to glue living cells together and harvest their extracellular matrix (ECM). The obtained ECM coatings have fewer cell fragment residues compared to those obtained through traditional cell lysis. This method maintains the activity of ECM proteins, promoting cell adhesion and growth. Moreover, ECM coatings from different functional cells can guide stem cell differentiation.
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
(2022)
