期刊
EXPERT REVIEW OF CLINICAL IMMUNOLOGY
卷 6, 期 6, 页码 939-955出版社
TAYLOR & FRANCIS LTD
DOI: 10.1586/ECI.10.68
关键词
antigens; autoimmune diabetes; humanized mice; NOD mice; therapies; Type 1 diabetes
类别
资金
- NIH [R01 DK064315, R56 AI088256, NS07098]
- Juvenile Diabetes Research Foundation International
- American Diabetes Association
- Irma T Hirschl/Monique Weill-Caulier Trust
The widely used nonobese diabetic (NOD) mouse model of autoimmune (Type 1) diabetes mellitus shares multiple characteristics with the human disease and studies employing this model continue to yield clinically relevant and important information Here, we review some of the recent key findings obtained from NOD mouse investigations that have both advanced our understanding of disease pathogenesis and suggested new therapeutic targets and approaches Areas discussed include antigen discovery identification of genes and pathways contributing to disease susceptibility development of strategies to image islet inflammation and the testing of therapeutics We also review recent technical advances that combined with an improved understanding of the NOD mouse model s limitations should work to ensure its popularity utility and relevance in the years ahead
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