期刊
EXPERT REVIEW OF CLINICAL IMMUNOLOGY
卷 6, 期 4, 页码 573-583出版社
TAYLOR & FRANCIS LTD
DOI: 10.1586/ECI.10.43
关键词
Crohn's disease; nutrigenetics; nutrigenomics; polyunsaturated fatty acids; ulcerative colitis; vitamin D
类别
资金
- AgResearch Ltd. (Palmerston North, New Zealand)
- Crop & Food Research (Palmerston North, New Zealand)
- HortResearch (Auckland, New Zealand)
- University of Auckland (Auckland, New Zealand)
- Foundation for Research Science and Technology
The field of nutrigenomics recognizes gene diet interactions, with regard to both the impact of genetic variation on nutrient requirements, and conversely nutrient regulation of the expression of genes. Crohn's disease and ulcerative colitis are inflammatory bowel diseases for which twin studies reveal genetic susceptibility that is impacted by diet and environment. Apparently contradictory data on the role of diet in inflammatory bowel disease would be entirely explainable if genetic variability determined dietary requirements and intolerances. Considering Crohn's disease, we recognize three major classes of genes. The first of these involves bacterial recognition through pattern recognition receptors and autophagy genes, while the second act through secondary immune response, and the third concern epithelial barrier integrity. Despite genetic overlap with CD, the first two groups of genes appear to be less important in ulcerative colitis, while other genes, particularly those involved in barrier function, gain prominence. Case control studies suggest that these different genetic groups reflect distinct dietary requirements. Such studies suggest nutrigenomic approaches to maintaining disease remission at present, and preventing disease development in the future.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据