期刊
EXPERT REVIEW OF CLINICAL IMMUNOLOGY
卷 6, 期 1, 页码 101-109出版社
TAYLOR & FRANCIS LTD
DOI: 10.1586/ECI.09.74
关键词
allergic rhinitis; asthma; eosinophilic esophagitis; murine models; Th2 cytokines
类别
资金
- NIH [AI064428-01, U01 AI088806]
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI062698, U01AI088806] Funding Source: NIH RePORTER
Eosinophilic esophagitis (EE) has an increased incidence of diagnosis similar to other atopic diseases. We present a recent literature review of the common features between atopic diseases (i.e., asthma, allergic rhinitis and atopic dermatitis) and EE. All of the disorders have allergen triggers and evidence of a possible Th2 inflammation at the site of disease. Murine models have also shown similar features with the importance of T cells and Th2 cytokines for the development of disease. The diseases share underlying inflammation with the potential for remodeling with an increase in TGF-beta expression in asthma and EE. However, differences do exist between the diseases in treatment and pathogenesis. For EE, there are two basic treatment options: avoidance of the food triggers or treatment of the eosinophilic inflammation with corticosteroids.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据