Article
Multidisciplinary Sciences
Hannah L. Miller, Prabhakar Sairam Andhey, Melissa K. Swiecki, Bruce A. Rosa, Konstantin Zaitsev, Alexandra-Chloe Villani, Makedonka Mitreva, Maxim N. Artyomov, Susan Gilfillan, Marina Cella, Marco Colonna
Summary: This study revealed that depletion of pDCs in mice through injection of diphtheria toxin can enhance Th2-dependent skin inflammation, independent of reduced IFN-I. Additionally, treatment with DT alters the representation of conventional dendritic cells in the skin-draining lymph nodes, leading to Th2-driven contact hypersensitivity.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
Chi-Chien Lin, Kai-Cheng Chuang, Shih-Wei Chen, Ya-Hsuan Chao, Chih-Ching Yen, Shang-Hsun Yang, Wei Chen, Kuang-Hsi Chang, Yu-Kang Chang, Chuan-Mu Chen
Summary: Lactoferrin exhibits anti-inflammation and immunoregulation activities in OVA-induced allergic asthma, ameliorating lung injury, decreasing Th2 cytokines and allergen-specific antibodies production, and influencing the functions of dendritic cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Tianheng Hou, Miranda Sin-Man Tsang, Lea Ling-Yu Kan, Peiting Li, Ida Miu-Ting Chu, Christopher Wai-Kei Lam, Chun-Kwok Wong
Summary: IL-37b has been shown to regulate basophil activation mediated by TSLP and reduce the release of IL-4, suggesting its potential as a target for alleviating symptoms of AD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Allergy
Justine Calise, Nahir Garabatos, Veronique Bajzik, Mary Farrington, David Robinson, David Jeong, Marco Londei, Erik Wambre
Summary: IL-33 plays a role in modulating circulating allergen-specific T-cell responses, with ST2 expression specifically associated with T(H)2A cell activation. IL-33 selectively amplifies pathogenic T(H)2 cell effector functions in allergy.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Immunology
Chao Gu, Katherine Upchurch, Joshua Horton, Mathew Wiest, Sandra Zurawski, Mark Millard, Robert R. Kane, HyeMee Joo, Lisa A. Miller, SangKon Oh
Summary: The study revealed that Dectin-1 can effectively control TSLP-induced Th2-type immune responses by reducing the expression of OX40L and CCL17. Experimental results showed that Dectin-1 activation can suppress allergic reactions and allergen-specific immune responses in both ex vivo and in vivo settings.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Amiko M. Uchida, Gabrielle Ro, Li Qiang, Kathryn A. Peterson, June Round, Michael Dougan, Stephanie K. Dougan
Summary: This study describes a method for differentiating eosinophils from hematopoietic stem cells and investigates their response to IL-33. The differentiated eosinophils displayed similar morphology and phenotype to peripheral eosinophils and showed increased expression of IL-33 receptors and cytokines in response to IL-33 stimulation. These findings suggest that eosinophils differentiated from CD34 cells can be used as a model to study type 2 inflammation in vitro.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Microbiology
Theodore J. Kottom, Eva M. Carmona, Andrew H. Limper
Summary: Pneumocystis sp. is a fungal pathogen that can cause pneumonia in immunocompromised individuals. The number of Pneumocystis jirovecii pneumonia (PJP) cases worldwide has reached over 500,000, and it is considered a priority pathogen by the WHO. While the use of antiretroviral therapy has reduced PJP cases in developed countries, the cases in non-HIV individuals receiving immunosuppressive therapies have increased. The role of alveolar macrophages in the immune response to Pneumocystis is well-established, but there is also emerging evidence on the involvement of epithelial cells.
Article
Biology
Risa Ebina-Shibuya, Erin E. West, Rosanne Spolski, Peng Li, Jangsuk Oh, Majid Kazemian, Daniel Gromer, Phillip Swanson, Ning Du, Dorian B. McGavern, Warren J. Leonard
Summary: TSLP plays a crucial role in the development of diseases such as asthma, atopic dermatitis, and allergic inflammation, but its role in CD8(+) T-cell primary responses and memory CD8(+) T cell responses to secondary viral infection is still controversial. Research has shown that TSLP limits the primary CD8(+) T-cell response to influenza, but has little effect on T cell function and the number of memory CD8(+) T cells generated after influenza infection, while inhibiting memory CD8(+) T-cell responses to secondary viral infections.
Article
Pediatrics
Kai Guan, Wenjing Zhu, Li Sha, Chuanhe Liu, Jing Zhao, Jia Yin, Yuzhi Chen
Summary: The prevalence of sensitization to aeroallergens increased with age in children with atopic diseases in Greater Beijing Region. Different age groups showed different sensitivities to different allergens. Sensitization to perennial allergens was associated with asthma risk.
FRONTIERS IN PEDIATRICS
(2022)
Article
Plant Sciences
Jung-Eun Lee, Young-Whan Choi, Dong-Soon Im
Summary: The aim of this study was to identify an active phytochemical from Schisandra chinensis and evaluate its effects on AD-like symptoms. The results showed that alpha-cubebenoate, an active phytochemical in Schisandra chinensis, significantly improved AD-like symptoms by reducing skin hypertrophy and mast cell accumulation, as well as decreasing pro-inflammatory chemokine and cytokine levels. This study provides evidence for the therapeutic efficacy of alpha-cubebenoate in the treatment of AD symptoms.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Allergy
Rinkesh K. Gupta, Jacqueline Miller, Michael Croft
Summary: This study found that the TNF family cytokine TWEAK plays an important role in keratinocyte dysregulation and the pathogenesis of AD. Blocking TWEAK and IL-13 had similar therapeutic effects in treating AD. Therefore, neutralizing TWEAK could be a potential therapeutic option for treating AD.
Article
Allergy
Niki D. Ubags, Aurelien Trompette, Julie Pernot, Britt Nibbering, Nicholas C. Wong, Celine Pattaroni, Alexis Rapin, Laurent P. Nicod, Nicola L. Harris, Benjamin J. Marsland
Summary: The research observed a mixed TH2/TH17 inflammatory response in adult mice, while neonatal mice did not develop overt skin inflammation but exhibited IL 17a release and TH2-dominated lung response. Mechanical skin barrier disruption was not enough to drive allergic skin inflammation, although it promoted systemic immune priming. The formation of the microbiome had a significant impact on enhanced chemokine and alarmin production, contributing to the development of overt skin disease.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Madathilparambil Suresh, Sinan Aktay, George Yalamanchili, Sumeet Solanki, Dily Thazhath Sathyarajan, Manikanta Swamy Arnipalli, Subramaniam Pennathur, Krishnan Raghavendran
Summary: Research findings indicate that hypoxia from lung injury following trauma is regulated by hypoxia-inducible factor 1 alpha (HIF-1 alpha), driving the acute inflammatory response in airway epithelial cells (AEC). Metabolomics profiling reveals increased glycolytic and TCA intermediates in Type II AEC after lung contusion, while succinate directly promotes inflammation in human small AEC.
Article
Immunology
Sandra Carignon, Dorian De Moura Rodrigues, David Gosset, Elodie Culerier, Sarah Huot-Marchand, Florence Savigny, Eric Kaya, Valerie Quesniaux, Aurelie Gombault, Isabelle Couillin, Bernhard Ryffel, Marc Le Bert, Nicolas Riteau
Summary: The pathogenesis of chronic lung diseases involves recurrent micro-injuries of the epithelium, with a major role of surfactant-producing alveolar epithelial type 2 (AT2) cells. This study investigated the contribution of gas exchange-permissive alveolar epithelial type 1 (AT1) cells in inflammation and interstitial fibrosis, by depleting AT1 cells through repeated injury. The findings suggest that targeting AT1 cell depletion could be a novel approach for investigating chronic lung inflammatory diseases and identifying new therapeutic targets.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Allergy
Joan M. Cook-Mills, Lauren N. Emmerson
Summary: Food allergy is closely associated with the development of atopic dermatitis. Mutations in skin barrier genes and environmental exposures can affect skin barrier function. In mouse studies, exposure to allergens on the skin induces food allergy, while coexposure of the skin to other environmental factors activates food allergy, allergen-specific IgE, and oral food-induced anaphylaxis. However, if the skin is exposed to environmental allergens at the time of initial oral food allergen consumption, the induction of tolerance may be blocked. Further research and clinical studies are needed to understand the mechanisms of food allergy induction and the effects of food allergens on the skin before the development of atopic dermatitis.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Oncology
Edward W. Roberts, Miranda L. Broz, Mikhail Binnewies, Mark B. Headley, Amanda E. Nelson, Denise M. Wolf, Tsuneyasu Kaisho, Dusan Bogunovic, Nina Bhardwaj, Matthew F. Krummel
Article
Multidisciplinary Sciences
Mark B. Headley, Adriaan Bins, Alyssa Nip, Edward W. Roberts, Mark R. Looney, Audrey Gerard, Matthew F. Krummel
Article
Multidisciplinary Sciences
Emma Lefrancais, Guadalupe Ortiz-Munoz, Axelle Caudrillier, Benat Mallavia, Fengchun Liu, David M. Sayah, Emily E. Thornton, Mark B. Headley, Tovo David, Shaun R. Coughlin, Matthew F. Krummel, Andrew D. Leavitt, Emmanuelle Passegue, Mark R. Looney
Article
Oncology
Andrew Zloza, A. Karolina Palucka, Lisa M. Coussens, Philip J. Gotwals, Mark B. Headley, Elizabeth M. Jaffee, Amanda W. Lund, Arlene H. Sharpe, Mario Sznol, Derek A. Wainwright, Kwok-Kin Wong, Marcus W. Bosenberg
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2017)
Article
Hematology
Guadalupe Ortiz-Munoz, Benat Mallavia, Adriaan Bins, Mark Headley, Matthew F. Krummel, Mark R. Looney
Article
Allergy
Hai-Chon Lee, Mark B. Headley, Yueh-Ming Loo, Aaron Berlin, Michael Gale, Jason S. Debley, Nicholas W. Lukacs, Steven F. Ziegler
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2012)
Article
Immunology
Hongwei Han, Mark B. Headley, Whitney Xu, Michael R. Comeau, Baohua Zhou, Steven F. Ziegler
JOURNAL OF IMMUNOLOGY
(2013)
Correction
Immunology
H. Han, W. Xu, M. B. Headley, H. K. Jessup, K. S. Lee, M. Omori, M. R. Comeau, A. Marshak-Rothstein, S. F. Ziegler
MUCOSAL IMMUNOLOGY
(2012)
Article
Immunology
H. Han, W. Xu, M. B. Headley, H. K. Jessup, K. S. Lee, M. Omori, M. R. Comeau, A. Marshak-Rothstein, S. F. Ziegler
MUCOSAL IMMUNOLOGY
(2012)
Article
Multidisciplinary Sciences
Mark C. Siracusa, Steven A. Saenz, David A. Hill, Brian S. Kim, Mark B. Headley, Travis A. Doering, E. John Wherry, Heidi K. Jessup, Lori A. Siegel, Taku Kambayashi, Emily C. Dudek, Masato Kubo, Antonella Cianferoni, Jonathan M. Spergel, Steven F. Ziegler, Michael R. Comeau, David Artis
Article
Multidisciplinary Sciences
Omar Khan, Mark Headley, Audrey Gerard, Wei Wei, Limin Liu, Matthew F. Krummel
Review
Immunology
Efrat Lelkes, Mark B. Headley, Emily E. Thornton, Mark R. Looney, Matthew F. Krummel
TRENDS IN IMMUNOLOGY
(2014)
Article
Immunology
Franz Puttur, Laura Denney, Lisa G. Gregory, Juho Vuononvirta, Robert Oliver, Lewis J. Entwistle, Simone A. Walker, Mark B. Headley, Ewan J. McGhee, James E. Pease, Matthew F. Krummel, Leo M. Carli, Clare M. Lloyd
SCIENCE IMMUNOLOGY
(2019)
Article
Immunology
Tanya S. Freedman, Mark B. Headley, Nina Serwas, Megan Ruhland, Carlos A. Castellanos, Alexis J. Combes, Matthew F. Krummel
JOURNAL OF EXPERIMENTAL MEDICINE
(2020)
Article
Multidisciplinary Sciences
Etienne Becht, Daniel Tolstrup, Charles-Antoine Dutertre, Peter A. Morawski, Daniel J. Campbell, Florent Ginhoux, Evan W. Newell, Raphael Gottardo, Mark B. Headley
Summary: The development of Infinity Flow, which combines hundreds of overlapping flow cytometry panels using machine learning, enables the simultaneous analysis of coexpression patterns of hundreds of surface-expressed proteins across millions of individual cells, allowing comprehensive analysis of cellular constituency and identification of previously unknown cellular heterogeneity. Through supervised machine learning, Infinity Flow enhances the accuracy and depth of clustering or dimensionality reduction algorithms, making it a highly scalable, low-cost solution for single-cell proteomics in complex tissues.
