☆ 4.3 Review

Role of intensity-modulated radiation therapy in gastrointestinal cancer

EXPERT REVIEW OF ANTICANCER THERAPY (2009)

期刊

EXPERT REVIEW OF ANTICANCER THERAPY

卷 9, 期 5, 页码 637-647

出版社

TAYLOR & FRANCIS LTD

DOI: 10.1586/ERA.09.16

关键词

anal cancer; gastric cancer; gastrointestinal malignancy; intensity-modulated radiation therapy; pancreatic cancer; rectal cancer

类别

Oncology

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Reagent

摘要

Intensity-modulated radiation therapy (IMRT) represents a powerful advance in the planning and delivery of radiation therapy owing to its ability to deliver highly conformal treatment doses while sparing normal tissues. Dosimetric studies have shown the feasibility and theoretical benefit of treating with IMRT over 3D-conformal radiation therapy in gastrointestinal malignancies. Early clinical experience with IMRT in the treatment of gastric, pancreatic, rectal and anal cancers corroborates the closimetric analyses, with some series reporting lower normal tissue toxicities. This article reviews the radiobiological, physical, technical and clinical aspects of IMRT for gastric, pancreatic, rectal and anal cancer, and summarizes the closimetric and outcome studies to date.

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