期刊
EXPERT REVIEW OF ANTI-INFECTIVE THERAPY
卷 10, 期 11, 页码 1241-1247出版社
EXPERT REVIEWS
DOI: 10.1586/ERI.12.114
关键词
CCR5 antagonist; maraviroc; tropism
资金
- Bristol-Myers Squibb
- GlaxoSmithKline
- Pfizer
- Roche
- Janssen-Cilag
- ViiV Healthcare
Expert Rev. Anti Infect. Ther. 10(11), 1241-1247 (2012) Although the use of combination antiretroviral therapy has resulted in spectacular improvements in morbidity and mortality of HIV-1 infected patients, a need for the development of antiretroviral compounds with new mechanisms of action remains. Maraviroc (Celsentri (R); ViiV Healthcare, Middlesex, UK) is the only drug of the class of chemokine (C-C motif) receptor 5 antagonists registered for treatment for HIV-1-infected antiretroviral therapy-experienced patients. Registration was based on the MOTIVATE-1 and -2 studies, which compared the efficacy and tolerability of maraviroc in combination with optimized background therapy with placebo. The aim of this paper is to review the MOTIVATE studies and to discuss issues related to maraviroc therapy in clinical practice such as assessment of HIV-1 coreceptor tropism.
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