Immunopathogenesis of falciparum malaria: implications for adjunctive therapy in the management of severe and cerebral malaria

The Neuropathology of Fatal Cerebral Malaria in Malawian Children

(2011) Katerina Dorovini-Zis et al.   AMERICAN JOURNAL OF PATHOLOGY

Functional architecture of Weibel-Palade bodies

(2011) K. M. Valentijn et al.   BLOOD

Endothelial activation and dysregulation in malaria: a potential target for novel therapeutics

(2011) Hani Kim et al.   CURRENT OPINION IN HEMATOLOGY

Recombinant human erythropoietin ameliorated endothelial dysfunction and macrophage infiltration by increasing nitric oxide in hypertensive 5/6 nephrectomized rat aorta

(2011) Hiroe Toba et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Nitric Oxide Protection Against Murine Cerebral Malaria Is Associated With Improved Cerebral Microcirculatory Physiology

(2011) Pedro Cabrales et al.   JOURNAL OF INFECTIOUS DISEASES

Pentoxifylline as an adjunct therapy in children with cerebral malaria

(2011) Bertrand Lell et al.   MALARIA JOURNAL

Fluid Resuscitation in Acute Illness — Time to Reappraise the Basics

(2011) John A. Myburgh   NEW ENGLAND JOURNAL OF MEDICINE

Mortality after Fluid Bolus in African Children with Severe Infection

(2011) Kathryn Maitland et al.   NEW ENGLAND JOURNAL OF MEDICINE

Combinations of Host Biomarkers Predict Mortality among Ugandan Children with Severe Malaria: A Retrospective Case-Control Study

(2011) Laura K. Erdman et al.   PLoS One

Specific Receptor Usage in Plasmodium falciparum Cytoadherence Is Associated with Disease Outcome

(2011) Lucy B. Ochola et al.   PLoS One

Structure of a Plasmodium falciparum PfEMP1 rosetting domain reveals a role for the N-terminal segment in heparin-mediated rosette inhibition

(2011) A. Juillerat et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vascular endothelial cells cultured from patients with cerebral or uncomplicated malaria exhibit differential reactivity to TNF

(2010) Samuel Crocodile Wassmer et al.   CELLULAR MICROBIOLOGY

Intravenous immunoglobulin in the treatment of paediatric cerebral malaria

(2010) T. E. TAYLOR et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

A Simple Score to Predict the Outcome of Severe Malaria in Adults

(2010) Josh Hanson et al.   CLINICAL INFECTIOUS DISEASES

Peroxisome proliferator activating receptor (PPAR) in cerebral malaria (CM): a novel target for an additional therapy

(2010) S. Balachandar et al.   EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

Adjunctive therapy for cerebral malaria and other severe forms ofPlasmodium falciparummalaria

(2010) Chandy C John et al.   Expert Review of Anti-Infective Therapy

Biomarkers for pediatric sepsis and septic shock

(2010) Stephen W Standage et al.   Expert Review of Anti-Infective Therapy

Magnetic Resonance Imaging Research in Sub-Saharan Africa: Challenges and Satellite-Based Networking Implementation

(2010) Matthew T. Latourette et al.   JOURNAL OF DIGITAL IMAGING

Artesunate versus quinine in the treatment of severe falciparum malaria in African children (AQUAMAT): an open-label, randomised trial

(2010) Arjen M Dondorp et al.   LANCET

Biomarkers and surrogate end points—the challenge of statistical validation

(2010) Marc Buyse et al.   Nature Reviews Clinical Oncology

Cerebral Malaria: Mechanisms of Brain Injury and Strategies for Improved Neurocognitive Outcome

(2010) Richard Idro et al.   PEDIATRIC RESEARCH

PPARγ agonists upregulate the barrier function of tight junctions via a PKC pathway in human nasal epithelial cells

(2010) Noriko Ogasawara et al.   PHARMACOLOGICAL RESEARCH

Oral Activated Charcoal Prevents Experimental Cerebral Malaria in Mice and in a Randomized Controlled Clinical Trial in Man Did Not Interfere with the Pharmacokinetics of Parenteral Artesunate

(2010) J. Brian de Souza et al.   PLoS One

Endothelium-Based Biomarkers Are Associated with Cerebral Malaria in Malawian Children: A Retrospective Case-Control Study

(2010) Andrea L. Conroy et al.   PLoS One

Cerebral malaria: human versus mouse studies

(2010) Mary M. Stevenson et al.   TRENDS IN PARASITOLOGY

Neuropathogenesis of human and murine malaria

(2010) Eleanor M. Riley et al.   TRENDS IN PARASITOLOGY

VEGF Promotes Malaria-Associated Acute Lung Injury in Mice

(2010) Sabrina Epiphanio et al.   PLoS Pathogens

Increased Asymmetric Dimethylarginine in Severe Falciparum Malaria: Association with Impaired Nitric Oxide Bioavailability and Fatal Outcome

(2010) Tsin W. Yeo et al.   PLoS Pathogens

Nano/Microfluidics for diagnosis of infectious diseases in developing countries

(2009) Won Gu Lee et al.   ADVANCED DRUG DELIVERY REVIEWS

Contrasting Actions of Selective Inhibitors of Angiopoietin-1 and Angiopoietin-2 on the Normalization of Tumor Blood Vessels

(2009) Beverly L. Falcón et al.   AMERICAN JOURNAL OF PATHOLOGY

High Levels of Plasmodium falciparum Rosetting in All Clinical Forms of Severe Malaria in African Children

(2009) Ogobara K. Doumbo et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Rapid activation of endothelial cells enables Plasmodium falciparum adhesion to platelet-decorated von Willebrand factor strings

(2009) D. J. Bridges et al.   BLOOD

Risk Factors for Severe Disease in Adults with Falciparum Malaria

(2009) Anastasia Phillips et al.   CLINICAL INFECTIOUS DISEASES

Are Studies on Severe Malaria Still Possible?

(2009) G. Dennis Shanks   CLINICAL INFECTIOUS DISEASES

Use of Peroxisome Proliferator‐Activated Receptor γ Agonists as Adjunctive Treatment forPlasmodium falciparumMalaria: A Randomized, Double‐Blind, Placebo‐Controlled Trial

(2009) Andrea K. Boggild et al.   CLINICAL INFECTIOUS DISEASES

Acquired Immunity to Malaria

(2009) D. L. Doolan et al.   CLINICAL MICROBIOLOGY REVIEWS

Biomarkers of sepsis

(2009) John C. Marshall et al.   CRITICAL CARE MEDICINE

PPARα and PPARγ attenuate HIV-induced dysregulation of tight junction proteins by modulations of matrix metalloproteinase and proteasome activities

(2009) Wen Huang et al.   FASEB JOURNAL

The Lambaréné Organ Dysfunction Score (LODS) Is a Simple Clinical Predictor of Fatal Malaria in African Children

(2009) Raimund Helbok et al.   JOURNAL OF INFECTIOUS DISEASES

Rosiglitazone Modulates the Innate Immune Response toPlasmodium falciparumInfection and Improves Outcome in Experimental Cerebral Malaria

(2009) Lena Serghides et al.   JOURNAL OF INFECTIOUS DISEASES

Relationship of Cell‐Free Hemoglobin to Impaired Endothelial Nitric Oxide Bioavailability and Perfusion in Severe Falciparum Malaria

(2009) Tsin W. Yeo et al.   JOURNAL OF INFECTIOUS DISEASES

COMP-Angiopoietin-1 decreases lipopolysaccharide-induced acute kidney injury

(2009) Duk Hoon Kim et al.   KIDNEY INTERNATIONAL

Erythropoietin and its receptors in the brainstem of adults with fatal falciparum malaria

(2009) Isabelle M Medana et al.   MALARIA JOURNAL

Safety of epoietin beta-quinine drug combination in children with cerebral malaria in Mali

(2009) Stéphane Picot et al.   MALARIA JOURNAL

Whole blood angiopoietin-1 and -2 levels discriminate cerebral and severe (non-cerebral) malaria from uncomplicated malaria

(2009) Andrea L Conroy et al.   MALARIA JOURNAL

Dysregulation of coagulation in cerebral malaria

(2009) Christopher Alan Moxon et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Diagnosis and management of the neurological complications of falciparum malaria

(2009) Saroj K. Mishra et al.   Nature Reviews Neurology

Cerebral malaria: why experimental murine models are required to understand the pathogenesis of disease

(2009) J. BRIAN de SOUZA et al.   PARASITOLOGY

Retinal Pathology of Pediatric Cerebral Malaria in Malawi

(2009) Valerie A. White et al.   PLoS One

Serum Angiopoietin-1 and -2 Levels Discriminate Cerebral Malaria from Uncomplicated Malaria and Predict Clinical Outcome in African Children

(2009) Fiona E. Lovegrove et al.   PLoS One

Damage control in host-pathogen interactions

(2009) R. Medzhitov   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recombinant Human Erythropoietin in the Treatment of Acute Ischemic Stroke

(2009) Hannelore Ehrenreich et al.   STROKE

The murine cerebral malaria phenomenon

(2009) Nicholas J. White et al.   TRENDS IN PARASITOLOGY

CD36 deficiency protects against malarial anaemia in children by reducingPlasmodium falciparum-infected red blood cell adherence to vascular endothelium

(2009) Jaffu Chilongola et al.   TROPICAL MEDICINE & INTERNATIONAL HEALTH

Severe Plasmodium falciparum Malaria Is Associated with Circulating Ultra-Large von Willebrand Multimers and ADAMTS13 Inhibition

(2009) Deirdre Larkin et al.   PLoS Pathogens

Artesunate–erythropoietin combination for murine cerebral malaria treatment

(2008) Anne-Lise Bienvenu et al.   ACTA TROPICA

Pharmacokinetics of L-Arginine in Adults with Moderately Severe Malaria

(2008) T. W. Yeo et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The angiopoietin-Tie2 system as a therapeutic target in sepsis and acute lung injury

(2008) Melanie van der Heijden et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Rosiglitazone Stimulates Nitric Oxide Synthesis in Human Aortic Endothelial Cells via AMP-activated Protein Kinase

(2008) James G. Boyle et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

VE-PTP maintains the endothelial barrier via plakoglobin and becomes dissociated from VE-cadherin by leukocytes and by VEGF

(2008) Astrid F. Nottebaum et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Recovery of Endothelial Function in Severe Falciparum Malaria: Relationship with Improvement in Plasmal‐Arginine and Blood Lactate Concentrations

(2008) Tsin W. Yeo et al.   JOURNAL OF INFECTIOUS DISEASES

Perfusion Abnormalities in Children with Cerebral Malaria and Malarial Retinopathy

(2008) Nicholas A. V. Beare et al.   JOURNAL OF INFECTIOUS DISEASES

Effect of a fall in malaria transmission on morbidity and mortality in Kilifi, Kenya

(2008) Wendy P O'Meara et al.   LANCET

Recombinant human erythropoietin increases survival and reduces neuronal apoptosis in a murine model of cerebral malaria

(2008) Lothar Wiese et al.   MALARIA JOURNAL

Plasma IP-10, apoptotic and angiogenic factors associated with fatal cerebral malaria in India

(2008) Vidhan Jain et al.   MALARIA JOURNAL

Blood Coagulation, Inflammation, and Malaria

(2008) Ivo M. B. Francischetti et al.   MICROCIRCULATION

Differential function of Tie2 at cell–cell contacts and cell–substratum contacts regulated by angiopoietin-1

(2008) Shigetomo Fukuhara et al.   NATURE CELL BIOLOGY

Angiopoietins assemble distinct Tie2 signalling complexes in endothelial cell–cell and cell–matrix contacts

(2008) Pipsa Saharinen et al.   NATURE CELL BIOLOGY

Immunity to malaria: more questions than answers

(2008) Jean Langhorne et al.   NATURE IMMUNOLOGY

Therapeutic potential of erythropoietin and its structural or functional variants in the nervous system

(2008) Anna-Leena Sirén et al.   Neurotherapeutics

Cerebral Malaria in Children Is Associated With Long-term Cognitive Impairment

(2008) C. C. John et al.   PEDIATRICS

High levels of erythropoietin are associated with protection against neurological sequelae in African children with cerebral malaria

(2008) C. Casals-Pascual et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Angiopoietin-2 is associated with decreased endothelial nitric oxide and poor clinical outcome in severe falciparum malaria

(2008) T. W. Yeo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clinical significance of sequestration in adults with severe malaria

(2008) A.M. Dondorp   TRANSFUSION CLINIQUE ET BIOLOGIQUE

Direct In Vivo Assessment of Microcirculatory Dysfunction in Severe Falciparum Malaria

(2007) A. M. Dondorp et al.   JOURNAL OF INFECTIOUS DISEASES