Review
Biochemistry & Molecular Biology
Xiaoxing Liu, Kai Yuan, Tangsheng Lu, Xiao Lin, Wei Zheng, Yanxue Xue, Jie Shi, Lin Lu, Ying Han
Summary: In 1986, Gawin and Kleber reported an increased drug craving in individuals with cocaine use disorders during prolonged abstinence, which was confirmed as the incubation of drug craving in rodent studies in 2001. The intensification of cue-induced drug craving after withdrawal puts abstinent individuals at a high risk of relapse, urging the development of effective interventions. Achievements have been made in deciphering neural mechanisms and identifying potential drug targets, neurotransmitters, neuropeptides, neurotrophic factors, and epigenetic markers, with implications for reducing drug craving and preventing relapse.
MOLECULAR PSYCHIATRY
(2023)
Editorial Material
Oncology
Francisco Hermida-Prado, Rinath Jeselsohn
Summary: ESR1 ligand-binding mutations, the most common genetic mechanism of acquired resistance to endocrine treatment, lead to constitutive ligand-independent activity, emerging under the selective pressure of aromatase inhibitors. New models of these mutations have been generated using CRISPR technology, shedding light on their functional consequences.
Review
Cell Biology
Ludi Yang, Xiang Gu, Jie Yu, Shengfang Ge, Xianqun Fan
Summary: Oncolytic viruses, either natural or genetically engineered, can replicate in tumor cells and inhibit tumor growth, making them an effective anticancer strategy. Their multifunctional characteristics suggest promising application prospects in cancer therapeutics.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Health Care Sciences & Services
Changwon Wang, Chungkeun Lee, Hangsik Shin
Summary: As a new therapeutic technique based on digital technology, the commercialization and clinical application of digital therapeutics (DTx) are increasing. However, the lack of consensus on a definition, insufficiencies in research and development, clinical trials, standardization of regulatory frameworks, and technological maturity have made the use of DTx as a general medical component ambiguous. This study investigates definitions, clinical trials, commercial products, and regulatory status related to DTx and suggests the necessity and considerations for international agreements on the definition and characteristics of DTx, focusing on commercialization characteristics.
NPJ DIGITAL MEDICINE
(2023)
Review
Chemistry, Physical
Chanyuan Jin, Sanjun Fang, Zechao Zhuang, Yongsheng Zhou
Summary: Single-atom nanozymes (SANs) are emerging catalytic nanomaterials with enzyme-like activities, which hold great promise in medical applications. This article presents the recent developments of SANs in anti-infective treatment, cancer diagnosis and therapy, biosensing, and antioxidative therapy.
Article
Hematology
Sangeetha Venugopal, Justin Watts
Summary: The discovery of IDH1 mutations in AML and the success of molecularly targeted therapies led to the development of IDH1mut inhibitors. Olutasidenib, a novel IDH1mut inhibitor, showed promising results in treating patients with R/R IDH1mut AML, including durable remission rates and transfusion independence. This review examines the development and positioning of olutasidenib in the treatment of IDH1mut AML.
Review
Chemistry, Physical
Chanyuan Jin, Sanjun Fan, Zechao Zhuang, Yongsheng Zhou
Summary: Single-atom nanozymes (SANs), a new type of catalytic nanomaterials with enzyme-mimetic activities, have gained extensive research attention in the fields of chemistry, energy conversion, and environmental purification. Recent studies have demonstrated the great potential of SANs in biological applications, including anti-infective treatment, cancer diagnosis and therapy, biosensing, and antioxidative therapy.
Review
Medicine, Research & Experimental
Miao Wang, Jie Rao, Meng Wang, Xiaosong Li, Kaili Liu, Mark F. Naylor, Robert E. Nordquist, Wei R. Chen, Feifan Zhou
Summary: The combination of targeted therapy and immunotherapy is considered an ideal strategy for treating metastatic cancer, with phototherapy emerging as a promising targeted therapy that can initiate antitumor immune responses through induced immunogenic tumor cell death. The use of phototherapy in conjunction with immunoadjuvant therapy has shown to induce a systemic antitumor immune response, controlling residual tumor cells at the treatment site and distant metastases.
Article
Engineering, Biomedical
Hatice B. Bingol, Johan C. M. E. Bender, Joost A. Opsteen, Sander C. G. Leeuwenburgh
Summary: Biodegradable bone adhesives are highly sought-after biomaterials that can replace traditional metallic devices for bone fixation. However, these biomaterials must meet numerous requirements, and commercially available bone-adhesive biomaterials that fulfill all of these requirements are currently not available. This comprehensive review provides an extensive overview of the development of bone adhesives from a translational perspective, highlighting the definition, classification, and chemistry of various types of bone adhesives. The review also focuses on materials capable of gluing two pieces of bone together within a time frame of minutes to days and critically reflects on commonly employed adhesion tests and the current state-of-the-art in their preclinical and clinical applicability.
MATERIALS TODAY BIO
(2023)
Review
Psychiatry
Julian Cheron, Alban de Kerchove d'Exaerde
Summary: Drug addiction causes millions of deaths per year worldwide, but misconceptions from the general public shadow its management as a chronic disease. Drug consumers are often stigmatized, leading to addiction being viewed as an individual issue rather than a societal one.
TRANSLATIONAL PSYCHIATRY
(2021)
Review
Biochemistry & Molecular Biology
Zita Szentkereszty-Kovacs, Krisztian Gaspar, Andrea Szegedi, Lajos Kemeny, Dora Kovacs, Daniel Torocsik
Summary: This review discusses the impact of alcohol on psoriatic patients, linking clinical observations with molecular background and providing insights on how this knowledge could influence treatment selection and patient management.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Chemistry, Multidisciplinary
Shijie Duan, Shuhang Wang, Lei Qiao, Xinbo Yu, Nan Wang, Liting Chen, Xinyuan Zhang, Xu Zhao, Hongyu Liu, Tianye Wang, Ying Wu, Ning Li, Funan Liu
Summary: With advancements in cancer biology and molecular virology, oncolytic virus-driven therapies have emerged as a promising alternative to traditional cancer treatments. However, current clinical trials have shown limited efficacy when using a single oncolytic virus. Integrated approaches combining immunotherapy, chemotherapy, or radiotherapy with oncolytic virus therapy have shown considerable effectiveness. Challenges in oncolytic virus therapy include restricted delivery and poor targeting. Further optimization of delivery methods is needed before oncolytic viruses can become a viable tumor treatment option.
Review
Immunology
Lucas Leite Cunha, Victor Alexandre dos Santos Valsecchi, Laura Sterian Ward
Summary: The immune response is remodeled with aging, which is called immunosenescence. Some scientists believe immunosenescence is an adaptation of the immune system to the aging environment, while others think aging leads to chronic inflammation. Studying immunosenescence can bring practical innovations to medicine and the health system.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Gastroenterology & Hepatology
Daolin Tang, Guido Kroemer, Rui Kang
Summary: The role of ferroptosis in hepatocellular carcinoma (HCC) is complex and diverse. While it can contribute to the progression of HCC, it might also be desirable to target ferroptosis in HCC cells. This review examines the mechanisms, regulation, biomarkers, and clinical implications of ferroptosis in HCC from cellular, animal, and human perspectives.
Review
Chemistry, Multidisciplinary
Khaled Seidi, Mohammad Hosein Ayoubi-Joshaghani, Mehdi Azizi, Tahereh Javaheri, Mehdi Jaymand, Effat Alizadeh, Thomas J. Webster, Amirhossein Ahmadieh Yazdi, Mostafa Niazi, Michael R. Hamblin, Zohreh Amoozgar, Rana Jahanban-Esfahlan
Summary: This article discusses the major applications of bioinspired hydrogels, emphasizing the importance of incorporating nature-inspired properties into their design. The authors suggest a multidisciplinary collaboration to pave the way for the entrance of bioinspired hydrogels into personalized medicine.