Article
Parasitology
Xuhui Zhang, Lamu Suolang, Yelei Ren, Yifei Wang, Yong Jiang, Xiaofei Zhong, Zehui Gou, Wu Zhou, Juan Chen, Yongzhong Li, Diming Cai
Summary: In this study, contrast-enhanced ultrasound (CEUS) was found to be more accurate than conventional ultrasound (US) in differentiating between cystic echinococcosis (CE) and alveolar echinococcosis (AE) in the liver. The accuracy rate for CEUS was 91.3%, while for US it was 65.2%. Therefore, CEUS can be considered a reliable tool for the differentiation of hepatic echinococcosis.
PARASITES & VECTORS
(2023)
Article
Parasitology
Tian Ma, Qian Wang, Mengmeng Hao, Chuizhao Xue, Xu Wang, Shuai Han, Qian Wang, Jiangshan Zhao, Xiao Ma, Xianglin Wu, Xiaofeng Jiang, Lei Cao, Yaming Yang, Yu Feng, Quzhen Gongsang, Juergen Scheffran, Liqun Fang, Richard James Maude, Canjun Zheng, Fangyu Ding, Weiping Wu, Dong Jiang
Summary: This study used the national echinococcosis survey data from 2012 to 2016 to investigate the spatial prevalence, demographic characteristics, and risk factors of cystic and alveolar echinococcosis in China. The results showed that female gender, older age, occupation as a herdsman or religious worker, and illiteracy were identified as risk factors for both types of echinococcosis. The prevalence of the diseases varied geographically, with high endemicity observed in the Tibetan Plateau region. Various environmental, biological, and social factors were found to be associated with the diseases. The findings will contribute to the development of targeted prevention measures and disease control strategies.
PARASITES & VECTORS
(2023)
Letter
Gastroenterology & Hepatology
Yusufukadier Maimaitinijiati, Yuan Meng, Xiong Chen
Summary: This letter highlights the importance of providing further information about the clinical stages, follow-up time, and clinical outcomes of patients in a study on liver alveolar echinococcosis. The authors' response and clarification on these issues would add value to their research.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Infectious Diseases
Li Wan, Bo Ran, Tuerganaili Aji, Yingmei Shao, Tiemin Jiang, Hao Wen
Summary: The study evaluated the safety and efficacy of laparoscopy in treating hepatic alveolar echinococcosis. Laparoscopic surgery was found to be safe and effective, with superior outcomes in terms of postoperative complications, catheterization time, and hospital stay compared to open surgery. Prospective, randomized trials are needed to confirm the superiority of laparoscopic surgery.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Surgery
Maximilian Denzinger, Nadir Nasir, Kira Steinkraus, Christoph Michalski, Felix J. Huetner, Benno Traub
Summary: The incidence of cystic and alveolar echinococcosis is increasing in Germany. Drug treatment and surgical resection, especially minimally invasive surgery, are the main therapeutic approaches. Benzimidazoles are effective drugs for both diseases but require lifelong follow-up and carry the risk of side effects and treatment progression. Individual risk-benefit assessment is needed for treatment strategies, especially for alveolar echinococcosis.
Article
Parasitology
Zhenzhong Bai, Xiao Ma, Ranran Yan, Wen Lei, Yifan Zhang, Yanming Ren, Shou Liu
Summary: This study investigated the metabolic variations in patients with active and inactive hepatic alveolar echinococcosis (AE) and cystic echinococcosis (CE), and identified serum biomarkers that can differentiate between the two diseases. Active AE lesions strongly alter amino acid metabolism in the host, while CE lesions have an altered metabolism of oxidative stress response. These changes in metabolic pathways can serve as biomarkers for early diagnosis of AE and CE.
Article
Nanoscience & Nanotechnology
Andi Dian Permana, Alejandro J. Paredes, Fabiana Volpe Zanutto, Muh Nur Amir, Ismail Ismail, Muh Akbar Bahar, Sumarheni, Santiago Daniel Palma, Ryan F. Donnelly
Summary: The study developed a nanocrystalline formulation of albendazole delivered intradermally using dissolving microneedles, which significantly improved the dissolution percentage and relative bioavailability of albendazole for the treatment of cystic echinococcosis.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Immunology
Fadime Eroglu, Mehmet Dokur, Yuksel Ulu
Summary: This study identified a miRNA profile that regulates T and B cell activity in patients with Alveolar and Cystic Echinococcosis, providing new insights into the early development mechanisms of these diseases.
PARASITE IMMUNOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Javier Collado Aliaga, Angela Romero-Alegria, Montserrat Alonso-Sardon, Vanessa Prieto-Vicente, Amparo Lopez-Bernus, Virginia Velasco-Tirado, Celia Sendra de la Ossa, Javier Pardo-Lledias, Moncef Belhassen-Garcia
Summary: Hepatic cystic echinococcosis is a rare cause of portal hypertension, with male gender and larger cyst size being main risk factors for its development. Patients with hepatic CE and portal hypertension have a higher mortality rate compared to those without portal hypertension.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xu Deng, Jing-jing Wang, Zhi-xin Wang, Hai-ning Fan, Hai-jiu Wang, Han-sheng Huang, Kai-qaing Wang, Xiao-zhou Yang, Jun-wei Han, Yangdan Cairang
Summary: This study evaluated the efficacy and safety of microwave ablation (MWA) in the treatment of hepatic alveolar echinococcosis (HAE). The results showed that MWA achieved a complete ablation rate of 100% with a recurrence rate of 13%. There were significant changes in certain laboratory indicators after MWA treatment. The study indicates that MWA may be a safe and effective treatment option for HAE.
BMC MEDICAL IMAGING
(2022)
Article
Parasitology
Li Wan, Bo Ran, Tuerganaili Aji, Paizula Shalayiadang, Tiemin Jiang, Yingmei Shao, Hao Wen
Summary: A retrospective study on 13 patients who underwent laparoscopic hepatectomy at the First Affiliated Hospital of Xinjiang Medical University showed that this approach is safe and effective for treating hepatic alveolar echinococcosis, with minimal postoperative complications. Further comparisons with traditional open surgery are needed to determine the advantages of laparoscopic hepatectomy for AE treatment.
Article
Public, Environmental & Occupational Health
Karlo Jelicic, Neven Papic, Klaudija Viskovic, Adriana Vince
Summary: A patient with advanced alveolar echinococcosis was effectively treated with a combination regimen of amphotericin B deoxycholate and mefloquine as a rescue therapy due to albendazole intolerance.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2023)
Article
Microbiology
Magdalena Stefaniak, Monika Derda, Pawel Zmora, Szymon Pawel Nowak
Summary: This study aimed to assess the risk factors of E. multilocularis infections and describe the clinical course of AE in 36 patients. Results showed that most patients were involved in farming, livestock breeding, forest work, or animal shelters. The majority of patients were diagnosed with E. multilocularis infection within 6 months using imaging and immunoassay techniques. All hospitalized patients initiated anti-parasitic therapy upon diagnosis. The study concludes that regular abdominal imaging examinations and detection of specific antibodies are recommended for individuals at risk, and regular screening tests in hyperendemic areas would improve early detection and clinical prognosis of this life-threatening parasitic disease.
Article
Microbiology
Thomas F. E. Barth, Adriano Casulli
Summary: Cystic and alveolar echinococcosis, caused by Echinococcus granulosus and Echinococcus multilocularis, are two neglected infectious diseases with distinct microscopic features and global public health impact. Pathologists have limited diagnostic experience due to the rarity of these zoonotic diseases, making immunohistology using monoclonal antibodies essential for definitive diagnosis.
Article
Biochemistry & Molecular Biology
Bin Li, Liang Wang, Xinwei Qi, Yumei Liu, Jiajun Li, Jie Lv, Xuan Zhou, Xuanlin Cai, Jiaoyu Shan, Xiumin Ma
Summary: In this study, the changes in NOTCH signaling pathway, as well as the fibrotic and inflammatory response of the liver after E. multilocularis infection, were analyzed using liver tissue samples from AE patients and an infected mouse model. It was found that blocking NOTCH signaling pathway exacerbates hepatic fibrosis levels and alters the polarization and origin of hepatic macrophages, suggesting the involvement of NOTCH3/DLL3 pathway in regulating macrophage polarization and fibrosis caused by AE.