The therapeutic potential of small-conductance KCa2 channels in neurodegenerative and psychiatric diseases

Do Patients With Alcohol Dependence Respond to Placebo? Results From the COMBINE Study

(2015) Roger D. Weiss et al.   Journal of Studies on Alcohol and Drugs

Learning Increases Intrinsic Excitability of Hippocampal Interneurons

(2013) B. M. McKay et al.   JOURNAL OF NEUROSCIENCE

Pharmacological enhancement of calcium-activated potassium channel function reduces the effects of repeated stress on fear memory

(2012) Derek Atchley et al.   BEHAVIOURAL BRAIN RESEARCH

Selective Positive Modulator of Calcium-Activated Potassium Channels Exerts Beneficial Effects in a Mouse Model of Spinocerebellar Ataxia Type 2

(2012) Adebimpe W. Kasumu et al.   CHEMISTRY & BIOLOGY

Trafficking of Intermediate (KCa3.1) and Small (KCa2.x) Conductance, Ca2+-Activated K+Channels: a Novel Target for Medicinal Chemistry Efforts?

(2012) Corina M. Balut et al.   ChemMedChem

Basis for allosteric open-state stabilization of voltage-gated potassium channels by intracellular cations

(2012) Samuel J. Goodchild et al.   JOURNAL OF GENERAL PHYSIOLOGY

Increasing SK2 channel activity impairs associative learning

(2012) Bridget M. McKay et al.   JOURNAL OF NEUROPHYSIOLOGY

Cerebellar Ataxia by Enhanced CaV2.1 Currents Is Alleviated by Ca2+-Dependent K+-Channel Activators in Cacna1aS218L Mutant Mice

(2012) Z. Gao et al.   JOURNAL OF NEUROSCIENCE

Early Presynaptic and Postsynaptic Calcium Signaling Abnormalities Mask Underlying Synaptic Depression in Presymptomatic Alzheimer's Disease Mice

(2012) S. Chakroborty et al.   JOURNAL OF NEUROSCIENCE

A randomized trial of varenicline (Chantix) for the treatment of spinocerebellar ataxia type 3

(2012) T. A. Zesiewicz et al.   NEUROLOGY

CyPPA, a Positive SK3/SK2 Modulator, Reduces Activity of Dopaminergic Neurons, Inhibits Dopamine Release, and Counteracts Hyperdopaminergic Behaviors Induced by Methylphenidate1

(2012) Kjartan F. Herrik et al.   Frontiers in Pharmacology

The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Guy M. McKhann et al.   Alzheimers & Dementia

Small-Conductance Ca2+-Activated K+ Channels: Form and Function

(2011) John P. Adelman et al.   Annual Review of Physiology

Chlorzoxazone, an SK-Type Potassium Channel Activator Used in Humans, Reduces Excessive Alcohol Intake in Rats

(2011) F. Woodward Hopf et al.   BIOLOGICAL PSYCHIATRY

SK2 Channels Are Neuroprotective for Ischemia-Induced Neuronal Cell Death

(2011) Duane Allen et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Early Changes in Cerebellar Physiology Accompany Motor Dysfunction in the Polyglutamine Disease Spinocerebellar Ataxia Type 3

(2011) V. G. Shakkottai et al.   JOURNAL OF NEUROSCIENCE

Negative Gating Modulation by (R)-N-(Benzimidazol-2-yl)-1,2,3,4-tetrahydro-1-naphthylamine (NS8593) Depends on Residues in the Inner Pore Vestibule: Pharmacological Evidence of Deep-Pore Gating of KCa2 Channels

(2011) D. P. Jenkins et al.   MOLECULAR PHARMACOLOGY

Learning and memory consolidation: linking molecular and behavioral data

(2011) I. Morgado-Bernal   NEUROSCIENCE

KCa2 channels activation prevents [Ca2+]i deregulation and reduces neuronal death following glutamate toxicity and cerebral ischemia

(2011) A M Dolga et al.   Cell Death & Disease

Prospective Follow-Up of Empirically Derived Alcohol Dependence Subtypes in Wave 2 of the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC): Recovery Status, Alcohol Use Disorders and Diagnostic Criteria, Alcohol Consumption Behavio

(2010) Howard B. Moss et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Blocking SK channels impairs long-term memory formation in young chicks

(2010) Kathryn D. Baker et al.   BEHAVIOURAL BRAIN RESEARCH

Small Conductance Calcium-Activated Potassium Type 2 Channels Regulate Alcohol-Associated Plasticity of Glutamatergic Synapses

(2010) Patrick J. Mulholland et al.   BIOLOGICAL PSYCHIATRY

KCa2 channels transiently downregulated during spatial learning and memory in rats

(2010) Bedel Mpari et al.   HIPPOCAMPUS

Allosteric Block of KCa2 Channels by Apamin

(2010) Cédric Lamy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NMDA-Mediated Ca2+ Influx Drives Aberrant Ryanodine Receptor Activation in Dendrites of Young Alzheimer's Disease Mice

(2010) I. Goussakov et al.   JOURNAL OF NEUROSCIENCE

KCa Channels as Therapeutic Targets in Episodic Ataxia Type-2

(2010) K. Alvina et al.   JOURNAL OF NEUROSCIENCE

Autosomal dominant cerebellar ataxias: polyglutamine expansions and beyond

(2010) Alexandra Durr   LANCET NEUROLOGY

What predicts mortality in Parkinson disease?: A prospective population-based long-term study

(2010) E. B. Forsaa et al.   NEUROLOGY

Riluzole in cerebellar ataxia: A randomized, double-blind, placebo-controlled pilot trial

(2010) G. Ristori et al.   NEUROLOGY

Reduced Nucleus Accumbens SK Channel Activity Enhances Alcohol Seeking during Abstinence

(2010) F. Woodward Hopf et al.   NEURON

Functional reduction of SK3-mediated currents precedes AMPA-receptor-mediated excitotoxicity in dopaminergic neurons

(2010) Bruno A. Benítez et al.   NEUROPHARMACOLOGY

Deviant Ryanodine Receptor-Mediated Calcium Release Resets Synaptic Homeostasis in Presymptomatic 3xTg-AD Mice

(2009) S. Chakroborty et al.   JOURNAL OF NEUROSCIENCE

NMDA receptor-dependent signaling pathways that underlie amyloid β-protein disruption of LTP in the hippocampus

(2009) Ghiam Yamin   JOURNAL OF NEUROSCIENCE RESEARCH

Alcohol and cause-specific mortality in Russia: a retrospective case–control study of 48 557 adult deaths

(2009) David Zaridze et al.   LANCET

Selective Activation of the SK1 Subtype of Human Small-Conductance Ca2+-Activated K+ Channels by 4-(2-Methoxyphenylcarbamoyloxymethyl)-piperidine-1-carboxylic Acid tert-Butyl Ester (GW542573X) Is Dependent on Serine 293 in the S5 Segment

(2009) C. Hougaard et al.   MOLECULAR PHARMACOLOGY

In vivo pharmacological manipulation of small conductance Ca2+-activated K+ channels influences motor behavior, object memory and fear conditioning

(2009) Kyle A. Vick et al.   NEUROPHARMACOLOGY

Alcoholism: A Systems Approach From Molecular Physiology to Addictive Behavior

(2009) Rainer Spanagel   PHYSIOLOGICAL REVIEWS

Secular Trends in Alcohol Consumption over 50 Years: The Framingham Study

(2008) Yuqing Zhang et al.   AMERICAN JOURNAL OF MEDICINE

Molecular and cellular basis of small- and intermediate-conductance, calcium-activated potassium channel function in the brain

(2008) P. Pedarzani et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

K+Channel Modulators for the Treatment of Neurological Disorders and Autoimmune Diseases

(2008) Heike Wulff et al.   CHEMICAL REVIEWS

Bis-Quinolinium Cyclophanes: Highly Potent and Selective Non-Peptidic Blockers of the Apamin-Sensitive Ca2+-Activated K+ Channel

(2008) Ana Conejo-Garcia et al.   CURRENT MEDICINAL CHEMISTRY

Schizophrenia: A Concise Overview of Incidence, Prevalence, and Mortality

(2008) J. McGrath et al.   EPIDEMIOLOGIC REVIEWS

SK channel function regulates the dopamine phenotype of neurons in the substantia nigra pars compacta

(2008) T.D. Aumann et al.   EXPERIMENTAL NEUROLOGY

Identification and characterization of a novel, shorter isoform of the small conductance Ca2+-activated K+channel SK2

(2008) Saravana R. K. Murthy et al.   JOURNAL OF NEUROCHEMISTRY

Modulation of SK Channel Trafficking by Beta Adrenoceptors Enhances Excitatory Synaptic Transmission and Plasticity in the Amygdala

(2008) E. S. L. Faber et al.   JOURNAL OF NEUROSCIENCE

Molecular mechanisms of stress-induced prefrontal cortical impairment: Implications for mental illness

(2008) A. B. Hains et al.   LEARNING & MEMORY

Naphtho[1,2-d]thiazol-2-ylamine (SKA-31), a New Activator of KCa2 and KCa3.1 Potassium Channels, Potentiates the Endothelium-Derived Hyperpolarizing Factor Response and Lowers Blood Pressure

(2008) A. Sankaranarayanan et al.   MOLECULAR PHARMACOLOGY

SK2 channel plasticity contributes to LTP at Schaffer collateral–CA1 synapses

(2008) Mike T Lin et al.   NATURE NEUROSCIENCE