Targeting neuroinflammation for therapeutic intervention in neurodegenerative pathologies: a role for the peptide analogue of thymulin (PAT)

TLR7 and TLR9 Trigger Distinct Neuroinflammatory Responses in the CNS

(2011) Niranjan B. Butchi et al.   AMERICAN JOURNAL OF PATHOLOGY

Pro-inflammatory cytokines intensify the activation of NO/NOS, JNK1/2 and caspase cascades in immature neurons exposed to elevated levels of unconjugated bilirubin

(2011) Ana R. Vaz et al.   EXPERIMENTAL NEUROLOGY

Antibody-based therapy in Alzheimer's disease

(2011) Refik Pul et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Toll-like receptors are key players in neurodegeneration

(2011) Daniela S. Arroyo et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Agonist activation of  7 nicotinic acetylcholine receptors via an allosteric transmembrane site

(2011) J. K. Gill et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Acetylcholine-Synthesizing T Cells Relay Neural Signals in a Vagus Nerve Circuit

(2011) M. Rosas-Ballina et al.   SCIENCE

Intrathecal injection of an alpha seven nicotinic acetylcholine receptor agonist attenuates gp120-induced mechanical allodynia and spinal pro-inflammatory cytokine profiles in rats

(2010) Lisa C. Loram et al.   BRAIN BEHAVIOR AND IMMUNITY

Brain homeostasis is maintained by “danger” signals stimulating a supportive immune response within the brain’s borders

(2010) Noga Ron-Harel et al.   BRAIN BEHAVIOR AND IMMUNITY

IL-10 within the CNS is necessary for CD4+ T cells to mediate neuroprotection

(2010) Junping Xin et al.   BRAIN BEHAVIOR AND IMMUNITY

Mechanisms Underlying Inflammation in Neurodegeneration

(2010) Christopher K. Glass et al.   CELL

Nonresolving Inflammation

(2010) Carl Nathan et al.   CELL

Biology of interleukin-10

(2010) Robert Sabat et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Chronic dizocilpine or apomorphine and development of neuropathy in two animal models II: Effects on brain cytokines and neurotrophins

(2010) Hassen Al-Amin et al.   EXPERIMENTAL NEUROLOGY

Inflammation in neurodegenerative diseases

(2010) Sandra Amor et al.   IMMUNOLOGY

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Thymulin related peptide attenuates inflammation in the brain induced by intracerebroventricular endotoxin injection

(2010) Bared Safieh-Garabedian et al.   NEUROPHARMACOLOGY

Pharmacological effects of nonselective and subtype-selective nicotinic acetylcholine receptor agonists in animal models of persistent pain

(2010) BaoXi Gao et al.   PAIN

The Thymus-Neuroendocrine Axis

(2009) Paula C. Reggiani et al.   Annals of the New York Academy of Sciences

Dual functionality of interleukin-1 family cytokines: implications for anti-interleukin-1 therapy

(2009) NM Luheshi et al.   BRITISH JOURNAL OF PHARMACOLOGY

Anandamide enhances IL-10 production in activated microglia by targeting CB2receptors: Roles of ERK1/2, JNK, and NF-κB

(2009) Fernando Correa et al.   GLIA

CD4-Positive T Lymphocytes Provide a Neuroimmunological Link in the Control of Adult Hippocampal Neurogenesis

(2009) S. A. Wolf et al.   JOURNAL OF IMMUNOLOGY

Cholinergic control of inflammation

(2009) M. Rosas-Ballina et al.   JOURNAL OF INTERNAL MEDICINE

Interleukin-10 provides direct trophic support to neurons

(2009) Zhigang Zhou et al.   JOURNAL OF NEUROCHEMISTRY

Does neuroinflammation fan the flame in neurodegenerative diseases?

(2009) Tamy C Frank-Cannon et al.   Molecular Neurodegeneration

Harnessing Immune Alterations in Neurodegenerative Diseases

(2009) Maria Björkqvist et al.   NEURON

A randomized, double-blind, placebo-controlled trial evaluating the efficacy and safety of ABT-594 in patients with diabetic peripheral neuropathic pain

(2009) Michael C. Rowbotham et al.   PAIN

Acetylcholine regulation of synoviocyte cytokine expression by the α7 nicotinic receptor

(2008) Jean-Marc Waldburger et al.   ARTHRITIS AND RHEUMATISM

Inhibition of NMDA-induced outward currents by interleukin-1β in hippocampal neurons

(2008) Ruoyu Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Thymulin Inhibits Monocrotaline-Induced Pulmonary Hypertension Modulating Interleukin-6 Expression and Suppressing p38 Pathway

(2008) Tiago Henriques-Coelho et al.   ENDOCRINOLOGY

Central nervous action of interleukin-1 mediates activation of limbic structures and behavioural depression in response to peripheral administration of bacterial lipopolysaccharide

(2008) J. P. Konsman et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Can the immune system be harnessed to repair the CNS?

(2008) Phillip G. Popovich et al.   NATURE REVIEWS NEUROSCIENCE

CD4+ T cells support glial neuroprotection, slow disease progression, and modify glial morphology in an animal model of inherited ALS

(2008) D. R. Beers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Why neurodegenerative diseases are progressive: uncontrolled inflammation drives disease progression

(2008) Hui-Ming Gao et al.   TRENDS IN IMMUNOLOGY

Barriers in the brain: a renaissance?

(2008) Norman R. Saunders et al.   TRENDS IN NEUROSCIENCES

The alpha7 nicotinic acetylcholine receptor as a pharmacological target for inflammation

(2007) W J Jonge et al.   BRITISH JOURNAL OF PHARMACOLOGY

Alpha7 nicotinic acetylcholine receptor: A link between inflammation and neurodegeneration

(2007) Concepcion Conejero-Goldberg et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS