Review
Immunology
Lourdes Rocamora-Reverte, Franz Leonard Melzer, Reinhard Wuerzner, Birgit Weinberger
Summary: The immune system is a tightly regulated network, where regulatory T cells play an important role in maintaining immune homeostasis. Different types of T cells have regulatory functions in modulating immune responses, and the aging process can affect the composition of immune cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Cell Biology
Ariadni Androvitsanea, Kostas Stylianou, Eleni Drosataki, Ioannis Petrakis
Summary: Research has shown that heat-shock proteins can have varying effects on the immune system, either triggering immune responses or alleviating them, which is important for studying and treating autoimmune diseases.
Review
Biochemistry & Molecular Biology
Stefan Tukaj, Krzysztof Sitko
Summary: Over a hundred different autoimmune diseases have been described to date, affecting various organs including the skin. The loss of immune tolerance in autoimmune diseases leads to chronic inflammation and tissue damage. Current treatments focus on immunosuppression but may cause serious adverse effects. Heat shock proteins Hsp90 and Hsp70 have been identified as potential therapeutic targets for autoimmune skin diseases.
Review
Allergy
Matteo Doglio, Tobias Alexander, Nicoletta Del Papa, John A. Snowden, Raffaella Greco
Summary: Systemic lupus erythematous is a heterogeneous autoimmune disease with a complex etiopathogenesis. Cellular therapies, such as autologous hematopoietic stem cell transplantation and regulatory T-cell therapy, have shown potential for providing more specific and sustainable treatment options for this disease.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Angela M. Mitchell, Aaron W. Michels
Summary: Despite progress in understanding the mechanisms behind autoimmune diseases, there is limited knowledge about protective mechanisms against these diseases. In the case of type 1 diabetes, pathogenic T cells that destroy pancreatic islets are well understood, but the immune-mediated mechanisms that contribute to protection against this disease are not fully elucidated. One potential protective mechanism involves regulatory CD4 T cells that suppress immune responses by recognizing self-peptides from islets. This review summarizes current knowledge about the antigenic self-peptides recognized by Tregs in the context of type 1 diabetes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Nicolas Krause, Joerg Mengwasser, Elpida Phithak, Francisca Beato, Marc Appis, Edgar Louis Milford, Johan Pratschke, Igor Sauer, Anja Kuehl, Arndt Vogel, Michael Goodyear, Linda Hammerich, Frank Tacke, Johanna Faith Haas, Tobias Mueller, Nalan Utku
Summary: IR1 cells are a subset of T regulatory cells that have immune suppressive functions and can inhibit proliferation in mixed lymphocyte reactions. They deliver regulatory signals by binding to their ligand, HLA-DR alpha 2, and have the potential to modulate immune dysregulation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Malak Fouani, Charbel A. Basset, Giuseppe D. Mangano, Lavinia G. Leone, Nada B. Lawand, Angelo Leone, Rosario Barone
Summary: This review sheds light on the neuroimmune function of different members of the heat shock protein (HSPs) family and the complex manifold actions that they exert during the course of rheumatoid arthritis (RA).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Rheumatology
Bingxia Ming, Yaowu Zhu, Jixin Zhong, Lingli Dong
Summary: Significant progress has been made in understanding the pathogenesis of SS, but effective treatments are still needed. Autoimmune lymphocytic infiltration is associated with glandular and extraglandular dysfunction in SS, affecting the epithelial structures of organs. Treg cells, a subset of CD4(+) T lymphocytes, play a role in inhibiting inflammation, immune response, and promoting tissue repair. The dysfunction of Treg cells in SS pathogenesis and potential therapeutic strategies targeting Treg cells are discussed in this review.
Review
Biochemistry & Molecular Biology
Natasa Kustrimovic, Daniela Gallo, Eliana Piantanida, Luigi Bartalena, Adriana Lai, Nicola Zerbinati, Maria Laura Tanda, Lorenzo Mortara
Summary: Maintaining the delicate balance between immune response and tolerance is crucial for health. T regulatory cells play a pivotal role in preserving self-tolerance and suppressing inflammation. In Graves' disease, these cells are likely impaired or reduced in frequency. Understanding the role of Tregs in Graves' disease is important for developing new treatment strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Immunology
Yuzhi Lu, Ni Xia, Xiang Cheng
Summary: Regulatory T cells (Tregs) play a crucial role in the development of chronic heart failure, suppressing excessive inflammatory responses and promoting stable scar formation in the early stage of heart injury. However, in chronic heart failure, the functions and phenotypes of Tregs change, transforming into a cell type that is harmful to the heart.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Environmental Sciences
Milton Talukder, Shao-Shuai Bi, Mei-Wei Lv, Jing Ge, Cong Zhang, Jin-Long Li
Summary: Cadmium exposure induces neuronal damage in the chicken brain, triggering the heat shock response (HSR) pathway and apoptotic pathway in response to the damage.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Review
Cell Biology
Louisa E. Sjaastad, David L. Owen, Sean I. Tracy, Michael A. Farrar
Summary: The concept of regulatory T cells (Tregs) as a subset critical for controlling immune responses has been solidified over the past few decades, with FOXP3 and IL2 playing key roles. Recent studies have shown extensive phenotypic and functional diversity within the Treg population.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Chemistry, Multidisciplinary
Hong-yun Wang, Jun-rui Ye, Li-yuan Cui, Shi-feng Chu, Nai-hong Chen
Summary: Recent evidence suggests that regulatory T (Treg) cells play a crucial role in immune regulation after ischemic stroke (IS), but their effects on IS outcomes remain controversial. Further research is needed to elucidate the mechanisms by which Treg cells modulate the immune responses induced by IS.
ACTA PHARMACOLOGICA SINICA
(2022)
Review
Biochemistry & Molecular Biology
Nicole Chizara Oparaugo, Kelsey Ouyang, Nam Phuong N. Nguyen, Amanda M. Nelson, George W. Agak
Summary: Regulatory T cells (Tregs) are crucial in maintaining immune tolerance and homeostasis by modulating immune system activation. They suppress the functions of effector T cells and antigen-presenting cells, but can lose their suppressive capability under certain conditions, leading to compromised immunity. This review focuses on the characteristics and mechanism of action of Tregs in autoimmune skin diseases, transplantation, and skin cancer, as well as the potential of Tregs-based cellular therapies in autoimmunity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Allergy
Kirstin Jansen, Lacin Cevhertas, Siyuan Ma, Pattraporn Satitsuksanoa, Mubeccel Akdis, Willem van de Veen
Summary: B cells play a central role in the immune system by producing antibodies, and they also have the capacity to regulate immune responses through various mechanisms. Regulatory B cells suppress inflammatory responses in autoimmune diseases, allergies, infections, transplants, and cancer, with key suppressive molecules like cytokines and cell membrane-bound molecules playing important roles. Regulatory B cells can be induced by different stimuli and play a role in altering inflammatory responses in various diseases.
Letter
Hematology
Annalisa Ruggeri, Liesbeth C. de Wreede, Carlheinz R. Muller, Pietro Crivello, Edouard F. Bonneville, Effie W. Petersdorf, Gerard Socie, Valerie Dubois, Riitta Niittyvuopio, Juha Perasaari, Ibrahim Yakoub-Agha, Jan J. Cornelissen, Lotte Wieten, Tobias Gedde-Dahl, Edouard Forcade, Charles R. Crawley, Steven G. E. Marsh, Virginie Gandemer, Eleni Tholouli, Claude-Eric Bulabois, Anne Huynh, Goda Choi, Eric Deconinck, Maija Itala-Remes, Stig Lenhoff, Mats Bengtsson, Jan-Erik Johansson, Gwendolyn van Gorkom, Jorinde D. Hoogenboom, Luca Vago, Vanderson Rocha, Chiara Bonini, Christian Chabannon, Katharina Fleischhauer
Article
Medicine, General & Internal
Linda Stevens Brentjens, Denise Habets, Janneke Den Hartog, Salwan Al-Nasiry, Lotte Wieten, Servaas Morre, Aafke Van Montfoort, Andrea Romano, Ron van Golde
Summary: This study aims to investigate the differences in endometrial receptivity parameters between women aged 18-38 with reproductive failure (RIF and RM) and fertile controls, focusing on steroid metabolism, uNK cells, and the microbiome.
Letter
Hematology
Lara S. Boerenkamp, Cilia R. Pothast, Romy C. Dijkland, Kayleigh van Dijk, Gwendolyn N. Y. van Gorkom, Inge H. M. van Loo, Lotte Wieten, Constantijn J. M. Halkes, Mirjam H. M. Heemskerk, Catharina H. M. J. Van Elssen
AMERICAN JOURNAL OF HEMATOLOGY
(2022)
Review
Oncology
Nicky A. Beelen, Femke A. Ehlers, Gerard M. J. Bos, Lotte Wieten
Summary: This review provides an overview of the impact of inhibitory KIR and NKG2A on NK cell-mediated ADCC response, emphasizing the rationale for combination strategies targeting inhibitory immune checkpoints and ADCC triggering antibodies.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Article
Oncology
Femke A. I. Ehlers, Niken M. Mahaweni, Annet van de Waterweg Berends, Thara Saya, Gerard M. J. Bos, Lotte Wieten
Summary: Multiple myeloma (MM) is an incurable disease characterized by malignant plasma cells in the bone marrow. The tumor microenvironment (TME) plays a crucial role in MM growth and is composed of various tumor-associated cells (TAC) that promote immunosuppression. This study explores the interaction between natural killer (NK) cells and TAC, namely tumor-associated macrophages (TAMs) and M1 macrophages, and investigates the potential enhancement of NK cell anti-tumor functions through an ADCC-triggering antibody targeting macrophages.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Article
Orthopedics
M. Teunissen, B. P. Meij, L. Snel, K. Coeleveld, J. Popov-Celeketic, I. S. Ludwig, F. Broere, F. P. J. G. Lafeber, M. A. Tryfonidou, S. C. Mastbergen
Summary: This study investigated the effects of knee joint distraction (KJD) on osteoarthritic joints in dogs at two consecutive timepoints. The results showed that although the cartilage was still in a catabolic state directly after KJD, there were signs of healing at 10 weeks of follow-up. The signaling pathways involved in the healing process, including TGF-beta and Notch pathways, were explored.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2023)
Article
Immunology
Leanne P. M. H. van Leeuwen, Marloes Grobben, Corine GeurtsvanKessel, Pauline Ellerbroek, Godelieve de Bree, Judith Potjewijd, Abraham H. Rutgers, Hetty Jolink, Frank van de Veerdonk, Marit L. van Gils, Rory de Vries, Virgil A. S. H. Dalm, VACOPID Res Grp
Summary: This study investigated the immune responses of 473 patients with inborn errors of immunity (IEI) 6 months after receiving mRNA-1273 COVID-19 vaccines. The results showed that antibody titers and T cell responses in IEI patients also declined after 6 months of vaccination, and were more likely to drop below normal levels compared to healthy individuals. Additionally, the effectiveness of a third mRNA COVID-19 vaccine was limited in patients with common variable immunodeficiency (CVID) who did not seroconvert after previous vaccinations.
JOURNAL OF CLINICAL IMMUNOLOGY
(2023)
Article
Virology
Sandra Vreman, Elisabeth M. D. L. van der Heijden, Lars Ravesloot, Irene S. Ludwig, Judith M. A. van den Brand, Frank Harders, Andries A. Kampfraath, Herman F. Egberink, Jose L. Gonzales, Nadia Oreshkova, Femke Broere, Wim H. M. van der Poel, Nora M. Gerhards
Summary: Several reports demonstrated domestic cats' susceptibility to SARS-CoV-2 infection. In this study, the immune responses in cats after experimental inoculation were investigated, along with infection kinetics and pathological lesions. Infected cats showed mild lung changes and viral antigen expression, but no clinical signs. Viral RNA was present in nasal and throat swabs until day 7, and infectious virus could be isolated from nose, trachea, and lungs until day 7. Cats developed a humoral immune response from day 7 onwards, with limited cellular immune responses on day 7.
Article
Multidisciplinary Sciences
Denise H. J. Habets, Salwan Al-Nasiry, Sietse Q. Nagelkerke, Christina E. M. Voorter, Marc E. A. Spaanderman, Taco W. Kuijpers, Lotte Wieten
Summary: This study found that the p.Val176Phe polymorphism in the FCGR3A gene is associated with recurrent pregnancy loss. Patients with at least one p.176Val variant showed increased expression of CD16a receptor and anti-HLA antibodies. However, there was no association between FCGR3A-p.176 polymorphism and the presence of class I and class II anti-HLA antibodies.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Alberta Giovanazzi, Martijn J. C. van Herwijnen, Marije Kleinjan, Gerbrich N. van der Meulen, Marca H. M. Wauben
Summary: Cell-derived extracellular vesicles (EVs) have gained attention as potential disease biomarkers. Identifying disease-associated EV signatures can enable the use of EV-based liquid biopsy. In this study, EVs were purified from human milk and serum samples and analyzed using flow cytometry with bead-bound antibodies. The study identified body fluid-specific EV signatures and markers associated with immune cells and stem cells. The study also found differences in tetraspanin distributions on EVs and their association with specific EV surface proteins, suggesting differences in EV biogenesis routes.
SCIENTIFIC REPORTS
(2023)
Article
Chemistry, Physical
Andrea Ridolfi, Jacopo Cardellini, Fatlinda Gashi, Martijn J. C. van Herwijnen, Martin Trulsson, Jose Campos-Teran, Marca H. M. Wauben, Debora Berti, Tommy Nylander, Joakim Stenhammar
Summary: Communication between cells in organisms relies on membrane-enveloped nanoparticles called extracellular vesicles (EVs). EV binding and uptake are influenced by the composition of the EV membrane and various colloidal forces, such as electrostatic and van der Waals forces. This study investigates the adsorption of EVs onto lipid membranes and demonstrates that electrostatic forces play a crucial role in controlling the adsorption. The findings provide insights into EV-membrane interactions and may contribute to the development of new strategies for EV separation and immobilization.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Nutrition & Dietetics
Lara S. Boerenkamp, Birgit L. M. G. Gijsbers, Erik-Jan Ververs, Eva M. S. Pijpers, Bart Spaetgens, Aniek de Coninck, Wilfred T. V. Germeraad, Will K. W. H. Wodzig, Lotte Wieten, Gwendolyn N. Y. van Gorkom, Catharina H. M. J. van Elssen
Summary: This study investigated the levels of serum and intracellular vitamin C in hospitalized COVID-19 patients and found lower serum vitamin C levels in severe and critical cases. The study suggests that intracellular vitamin C levels decrease during COVID-19 infection, while serum levels remain relatively stable. These findings highlight the importance of further research on the role and mechanisms of intracellular vitamin C in COVID-19 infection.
Article
Immunology
Nicky A. Beelen, Merel R. Aberle, Virginia Bruno, Steven W. M. Olde Damink, Gerard M. J. Bos, Sander S. Rensen, Lotte Wieten
Summary: This study evaluated the cytotoxic potential of adoptive NK cells against pancreatic cancer organoids and found that ADCC-inducing antibodies can enhance NK cell anti-tumor responses.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Chemistry, Medicinal
Ali Javed, Melanie D. Balhuizen, Arianne Pannekoek, Floris J. Bikker, Dani A. C. Heesterbeek, Henk P. Haagsman, Femke Broere, Markus Weingarth, Edwin J. A. Veldhuizen
Summary: This study systematically investigates the influence of O-antigen and Lipid A composition on the antibacterial and anti-endotoxin activity of four HDPs. The results show that O-antigen does not affect antibacterial activity, while Lipid A modification can affect the immunomodulatory role of HDPs. The findings have important implications for the application of HDPs in the treatment of infectious diseases.
Article
Cell Biology
Estefania Lozano-Andres, Agustin Enciso-Martinez, Abril Gijsbers, Andrea Ridolfi, Guillaume Van Niel, Sten F. W. M. Libregts, Claudio Pinheiro, Martijn J. C. van Herwijnen, An Hendrix, Marco Brucale, Francesco Valle, Peter J. Peters, Cees Otto, Ger J. A. Arkesteijn, Marca H. M. Wauben
Summary: Extracellular vesicles (EVs) in blood plasma have potential as biomarkers for disease. However, analyzing EVs at the single particle level is challenging due to the complexity of plasma. This study investigates the presence and formation of EV-lipoproteins particles (LPPs) complexes, and the impact of LPPs on EV analysis and biomarker profiling. The results demonstrate that EV-LPP complexes can form under physiological conditions, and the presence of LPPs can influence the quantitative and qualitative analysis of EVs.
JOURNAL OF EXTRACELLULAR VESICLES
(2023)