Peptide deformylase – a promising therapeutic target for tuberculosis and antibacterial drug discovery

Synthesis and Biological Aspects of Mycolic Acids: An Important Target AgainstMycobacterium tuberculosis

(2011) Marcus Vinícius Nora de Souza et al.   TheScientificWorldJOURNAL

Structure and Activity of Human Mitochondrial Peptide Deformylase, a Novel Cancer Target

(2009) Sindy Escobar-Alvarez et al.   JOURNAL OF MOLECULAR BIOLOGY

Inhibitors of FabI, an Enzyme Drug Target in the Bacterial Fatty Acid Biosynthesis Pathway

(2008) Hao Lu et al.   ACCOUNTS OF CHEMICAL RESEARCH

Early Bactericidal Activity and Pharmacokinetics of the Diarylquinoline TMC207 in Treatment of Pulmonary Tuberculosis

(2008) R. Rustomjee et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Insights into the substrate specificity of plant peptide deformylase, an essential enzyme with potential for the development of novel biotechnology applications in agriculture

(2008) Lynnette M. A. Dirk et al.   BIOCHEMICAL JOURNAL

Synthesis of methyl 5-S-alkyl-5-thio-d-arabinofuranosides and evaluation of their antimycobacterial activity

(2008) Aditya K. Sanki et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Small molecules with structural similarities to siderophores as novel antimicrobials against Mycobacterium tuberculosis and Yersinia pestis

(2008) Karen L. Stirrett et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Peptide deformylase inhibitors of Mycobacterium tuberculosis: Synthesis, structural investigations, and biological results

(2008) Arkadius Pichota et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Prediction of the binding modes between BB-83698 and peptide deformylase from Bacillus stearothermophilus by docking and molecular dynamics simulation

(2008) Qiang Wang et al.   BIOPHYSICAL CHEMISTRY

The Plastid-Like Organelle of Apicomplexan Parasites as Drug Target

(2008) J. Wiesner et al.   CURRENT PHARMACEUTICAL DESIGN

Lipiarmycin targets RNA polymerase and has good activity against multidrug-resistant strains of Mycobacterium tuberculosis

(2008) M. Kurabachew et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Three Consecutive Arginines Are Important for the Mycobacterial Peptide Deformylase Enzyme Activity

(2008) Rahul Saxena et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Origins of the Different Metal Preferences ofEscherichia coliPeptide Deformylase andBacillus thermoproteolyticusThermolysin: A Comparative Quantum Mechanical/Molecular Mechanical Study

(2008) Minghui Dong et al.   JOURNAL OF PHYSICAL CHEMISTRY B

A peptide deformylase–ribosome complex reveals mechanism of nascent chain processing

(2008) Rouven Bingel-Erlenmeyer et al.   NATURE

Rice Peptide Deformylase PDF1B is Crucial for Development of Chloroplasts

(2008) Sunok Moon et al.   PLANT AND CELL PHYSIOLOGY

Kinetics and Ligand-Binding Preferences of Mycobacterium tuberculosis Thymidylate Synthases, ThyA and ThyX

(2008) Joshua H. Hunter et al.   PLoS One

Structural studies of shikimate 5-dehydrogenase from Mycobacterium tuberculosis

(2008) Helen A. Arcuri et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Insight into the antibacterial drug design and architectural mechanism of peptide recognition from theE. faeciumpeptide deformylase structure

(2008) Ki Hyun Nam et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Exit Biology: Battle for the Nascent Chain

(2008) Maria Selmer et al.   STRUCTURE

The Mycobacterium tuberculosis MEP (2C-methyl-d-erythritol 4-phosphate) pathway as a new drug target

(2008) Hyungjin Eoh et al.   TUBERCULOSIS

Design and synthesis of macrocyclic peptidyl hydroxamates as peptide deformylase inhibitors

(2007) Gang Shen et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and Characterization of Cytidine Derivatives that Inhibit the Kinase IspE of the Non-Mevalonate Pathway for Isoprenoid Biosynthesis

(2007) Christine M. Crane et al.   ChemMedChem